Results 81 to 90 of about 333 (143)

Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease

FASEB BioAdvances, Volume 7, Issue 11, November 2025.
Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur, Sonal Padole, Tapati Sarkar, Somasundaram Arumugam, Shiladitya Chattopadhyay   +4 more
wiley   +1 more source

Revealing the role of U2AF1 in splicing regulation and chimeric RNA dynamics

Scientific Reports
U2 small nuclear ribonucleoprotein auxiliary factor 1 (U2AF1) gene is a pivotal splicing factor frequently mutated in various malignancies, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).
Sangeen Khan, Yue Tang, Yangyang Guo, Jing Feng, Hui Wu, Zhenguo Song, Chengjuan Zhang, Fujun Qin   +7 more
doaj   +1 more source

Combinatorial Analyses of Pre‐mRNA Splicing‐Defective Mutants Reveal Differential Quantitative Requirements for Shelterin in Distinct Telomere Functions

Genes to Cells, Volume 30, Issue 6, November 2025.
Different telomere functions show distinct dependence on Rap1 protein levels revealed by analyses of pre‐mRNA splicing mutants. ABSTRACT Telomeres perform multiple functions to maintain genome stability, including telomere length regulation, chromosome end protection, and meiotic chromosome dynamics.
Miho Takeuchi, Yoko Otsubo, Junko Kanoh
wiley   +1 more source

Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges

Advanced NanoBiomed Research, Volume 5, Issue 10, October 2025.
Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou, Tianyi Xia, Jiheng Xiao, Jianhui Xiang, Hanhong Fang, Haoran Zhou, Yiqiang Hu, Liming Xiong   +7 more
wiley   +1 more source

A Prenatal Diagnosis of Verheij Syndrome in a Fetus Harboring a de novo PUF60 Variant

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Here, we report the case of a fetus affected by multiple congenital anomalies (MCA) syndrome detected during the second trimester through ultrasound scan, in which a de novo pathogenetic variant in the PUF60 gene (NM_078480.3:c.382_383del; p.Met128ValfsTer11) was identified by trio‐based exome sequencing.
Catia Mio, Maria Orsaria, Alessandra Franzoni, Elisa Bregant, Elena Betto, Jessica Zucco, Eliana Demori, Giuseppe Damante, Flavio Faletra   +8 more
wiley   +1 more source

Additional file 6 of Phylogenetic analysis and stress response of the plant U2 small nuclear ribonucleoprotein B″ gene family

, 2022
Additional file 6: Table S5. Sequence summary of plant U2B″ protein-protein interaction network.
Gao, Cong, Lu, Shuai, Zhou, Rong, Ding, Junjie, Fan, Jialiang, Han, Binying, Chen, Moxian, Wang, Baohua, Cao, Yunying   +8 more
openaire   +1 more source

SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c‐FOS Expression and Represents a Potential Therapeutic Target

Advanced Science, Volume 12, Issue 36, September 25, 2025.
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu, Yi Gu, Hengrui Zhang, Wunan Huang, Lei Sun, Liangjian Ma, Xiaolei Liang, Lexin Liu, Guiping Chen, Weihua Wang, Zhongkai Cao, Xue Li, Xiangjun Chen, Lidan Hu   +13 more
wiley   +1 more source

Additional file 2 of Phylogenetic analysis and stress response of the plant U2 small nuclear ribonucleoprotein B″ gene family

, 2022
Additional file 2: Table S1. Sequence summary of plant U2B″ gene phylogenetic analysis.
Gao, Cong, Lu, Shuai, Zhou, Rong, Ding, Junjie, Fan, Jialiang, Han, Binying, Chen, Moxian, Wang, Baohua, Cao, Yunying   +8 more
openaire   +1 more source

Nuclear RNA-binding proteins meet cytoplasmic viruses [PDF]

Cytoplasmic viruses interact intricately with the nuclear pore complex and nuclear import/export machineries, affecting nuclear-cytoplasmic trafficking.
Castello, Alfredo, Kamel, Wael
core   +1 more source

LINF_360010700

, 2023
U2 small nuclear ribonucleoprotein 16.5KLeishmania infantum (strain JPCM5)THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Requena, J (via Mendeley Data)
core   +1 more source