Results 31 to 40 of about 12,272 (217)

Suppressed <i>SF3B1</i> Expression Lowers <i>METTL3</i> Transcription and m⁶A RNA Expression. [PDF]

Int J Mol Sci
Splicing factor 3b1 (SF3B1), a component of U2 small nuclear ribonucleoprotein (U2 snRNP), has been known for its essential roles in pre-mRNA splicing and alternative splicing.
Choi N, Ashraf H, Shen H.
europepmc   +2 more sources

Molecular heterogeneity and prognostic biomarkers in primary meningeal melanocytic tumors. [PDF]

Brain Pathol
Integrated molecular profiling reveals biological heterogeneity among primary meningeal melanocytic tumors, identifying intermediate‐grade PMMT subgroups with distinct recurrence risk. Molecular alterations including SF3B1 mutations and chromosome 8q gains support prognostic stratification, while PRKAR1A alterations and chromosome 17/21q losses aid ...
Paterra R, Patanè M, Stroppa A, Marucci G, Ammendola S, Asioli S, Barresi V.   +6 more
europepmc   +2 more sources

Circumscribed Meningeal Melanocytic Neoplasms: CNS WHO Grade, Molecular Profile, and Clinical Outcomes. [PDF]

Brain Pathol
In this study including 31 circumscribed meningeal melanocytic neoplasms (melanocytoma, intermediate‐grade melanocytic tumor [IMT], and melanoma), overall survival (OS) differed significantly among the groups, with melanoma showing significantly worse OS than melanocytoma and IMT showing intermediate OS between melanocytoma and melanoma.
Zhu Y, Karbhari N, Kaufmann TJ, Raghunathan A, Ida CM, Zepeda-Mendoza CJ, Dryden IJ, Salamat S, Atherton C, Jenkins SM, Markovic SN, Sener UT, Giannini C.   +12 more
europepmc   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes. [PDF]

Mol Oncol
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Thalla R, Lamichhane J, Lewis C, Breslin P, Zhang J.   +4 more
europepmc   +2 more sources

Splicing Factor Mutations in Clonal Hematopoiesis and Progression to Myeloid Neoplasms. [PDF]

Cancer Sci
Splicing factor (SF)‐mutant CH is characterized by relatively late emergence and accelerated clonal expansion in older individuals. This review summarizes its clonal dynamics, disease‐associated consequences of SF mutations in myeloid neoplasms, and candidate mechanisms that may contribute to age‐dependent selection.
Lyu Y, Zhang Y, Kon A.
europepmc   +2 more sources

Supporting data for “Elucidating the Role of PHF5A-SF3B1-DLC1 Splicing Complex in Avian Trunk Neural Crest Specification”

, 2022
   This dataset contains multiple qualitative and quantitative analyses mentioned below and two oral/poster presentation files related to the study of splicing complex PHF5A-SF3B1-DLC1 on the expression of specifier genes in avian trunk neural crest ...
Zhengfan Zheng (9067496)
core   +1 more source

A Rare Case of Plasma Cell Myeloma, Myelodysplastic Neoplasm with Low Blast and SF3B1 Mutation and Dyserythropoiesis with Ring Sideroblasts [PDF]

Journal of Liaquat National Hospital
Myelodysplastic syndromes (MDS) are heterogeneous hematological neoplasms which lead to dysplasia, cytopenia and hematopoiesis. They have a risk of transforming into Acute Myeloid Leukemia (AML) in some cases.
Shamail Zia, Brenda Ly, Alma Sanchez Salazar, Bridget Herschap, Aamir Ehsan   +4 more
doaj   +1 more source

SF3B1 and the riddle of the ring sideroblast [PDF]

Blood, 2012
In this issue of Blood , Visconte and colleagues report on their investigations into the pathophysiologic effects of altered SF3B1 in patients with myelodysplastic syndromes (MDS).[1][1] A crucial component of the spliceosomal U2snRNP complex, SF3B1 participates in normal RNA splicing.
openaire   +2 more sources

SF3B1 mutations in chronic lymphocytic leukemia [PDF]

Blood, 2013
Abstract SF3B1 is a critical component of the splicing machinery, which catalyzes the removal of introns from precursor messenger RNA (mRNA). Next-generation sequencing studies have identified mutations in SF3B1 in chronic lymphocytic leukemia (CLL) at high frequency.
Youzhong, Wan, Catherine J, Wu
openaire   +2 more sources

SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS

Journal of Hematology & Oncology, 2018
Background SF3B1 is a core component of splicing machinery. Mutations in SF3B1 are frequently found in myelodysplastic syndromes (MDS), particularly in patients with refractory anemia with ringed sideroblasts (RARS), characterized by isolated anemia ...
Yumin Huang, John Hale, Yaomei Wang, Wei Li, Shijie Zhang, Jieying Zhang, Huizhi Zhao, Xinhua Guo, Jing Liu, Hongxia Yan, Karina Yazdanbakhsh, Gang Huang, Christopher D. Hillyer, Narla Mohandas, Lixiang Chen, Ling Sun, Xiuli An   +16 more
doaj   +1 more source