Results 21 to 30 of about 5,805 (197)
eLife, 2016 The DEAH-box NTPase Prp43 and its cofactors Ntr1 and Ntr2 form the NTR complex and are required for disassembling intron-lariat spliceosomes (ILS) and defective earlier spliceosomes.
Jean-Baptiste Fourmann +7 more
doaj +1 more source
Cloning and tissue expression of alternative spliceosome in chicken G-protein alpha subunit gene
浙江大学学报. 农业与生命科学版, 2019 In order to research deeply the transcription and splicing situations of chicken G-protein alpha subunit gene (GNAS), we used 5´ and 3´ rapid-amplification cDNA end (RACE) technology to clone and sequence the chicken GNAS gene, and used quantitative ...
ZHANG Xuedong +6 more
doaj +1 more source
Therapeutic Targeting of Alternative Splicing: A New Frontier in Cancer Treatment
Frontiers in Oncology, 2022 The ability for cells to harness alternative splicing enables them to diversify their proteome in order to carry out complex biological functions and adapt to external and internal stimuli. The spliceosome is the multiprotein-RNA complex charged with the
Anthony J. Murphy +3 more
doaj +1 more source
The spliceosome as a transposon sensor [PDF]
RNA Biology, 2013 The ability to distinguish self from non-self nucleic acids enables eukaryotes to suppress mobile elements and maintain genome integrity. In organisms from protist to human, this function is performed by RNA silencing pathways. There have been major advances in our understanding of the RNA silencing machinery, but the mechanisms by which these pathways
Dumesic, Phillip A, Madhani, Hiten D
openaire +4 more sources
Alternative Spliceosome Assembly Pathways Revealed by Single-Molecule Fluorescence Microscopy
Cell Reports, 2013 Removal of introns from nascent transcripts (pre-mRNAs) by the spliceosome is an essential step in eukaryotic gene expression. Previous studies have suggested that the earliest steps in spliceosome assembly in yeast are highly ordered and the stable ...
Inna Shcherbakova +7 more
doaj +1 more source
RNAtomy of the Spliceosome's heart [PDF]
The EMBO Journal, 2013 In his 1543 monumental work De humanis corpori fabrica , Andreas Vesalius used rigorous dissection practices and a mechanistic view of the organ's function to provide the first accurate anatomical description of a human heart. Guided by similar principles of meticulous structural probing and mechanistic explanatory potential, Anokhina and colleagues in
Sophie, Bonnal, Juan, Valcárcel
openaire +2 more sources
The MUC1 extracellular domain subunit is found in nuclear speckles and associates with spliceosomes. [PDF]
PLoS ONE, 2012 MUC1 is a large transmembrane glycoprotein and oncogene expressed by epithelial cells and overexpressed and underglycosylated in cancer cells. The MUC1 cytoplasmic subunit (MUC1-C) can translocate to the nucleus and regulate gene expression.
Priyadarsini Kumar +5 more
doaj +1 more source
Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression
eLife, 2020 Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome.
Stefan Meinke +6 more
doaj +1 more source
Hepatology Communications, 2022 CircRNAs have been reported to play crucial roles in tumor progression and recurrence, showing potential as biomarkers in cancer. However, the global abundance of circRNA and their involvement in hepatocellular carcinoma (HCC) development have not been ...
Lei He +11 more
doaj +1 more source
SF3b4: A Versatile Player in Eukaryotic Cells
Frontiers in Cell and Developmental Biology, 2020 Spliceosomes are large protein-RNA complexes regulating pre-mRNA processing in eukaryotes. SF3b4 encodes a core subunit of the U2-type spliceosome, loss- or gain-of-function of which often associates with abnormal cell growth, leading to tumorigenesis ...
Feng Xiong, Sha Li, Sha Li
doaj +1 more source