Results 21 to 30 of about 6,327 (242)
Roles of alternative splicing in infectious diseases: from hosts, pathogens to their interactions
Chinese Medical Journal, 2023 . Alternative splicing (AS) is an evolutionarily conserved mechanism that removes introns and ligates exons to generate mature messenger RNAs (mRNAs), extremely improving the richness of transcriptome and proteome. Both mammal hosts and pathogens require
Mengyuan Lyu +8 more
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Inhibición parcial de dos genes que codifican para proteínas del empalmosoma en Giardia intestinalis
Biomédica: revista del Instituto Nacional de Salud, 2016 Introducción. Giardia intestinalis es un organismo tempranamente divergente en el que recientemente se demostró la presencia de intrones. La maquinaria responsable de la remoción de intrones en organismos eucariotas superiores es el empalmosoma, el cual ...
Vanessa Gómez, Moisés Wasserman
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Intron lariat spliceosomes convert lariats to true circles: implications for intron transposition. [PDF]
Genes DevRare, full-length circular intron RNAs distinct from lariats have been reported in several species, but their biogenesis is not understood. We envisioned and tested a hypothesis for their formation using Saccharomyces cerevisiae, documenting full-length ...
Ares M, Igel H, Katzman S, Donohue JP.
europepmc +2 more sources
eLife, 2016 The DEAH-box NTPase Prp43 and its cofactors Ntr1 and Ntr2 form the NTR complex and are required for disassembling intron-lariat spliceosomes (ILS) and defective earlier spliceosomes.
Jean-Baptiste Fourmann +7 more
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Rearrangements within human spliceosomes captured after exon ligation [PDF]
, 2013 In spliceosomes, dynamic RNA/RNA and RNA/protein interactions position the pre-mRNA substrate for the two chemical steps of splicing. Not all of these interactions have been characterized, in part because it has not been possible to arrest the complex at
Burlingame, AL +3 more
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Cloning and tissue expression of alternative spliceosome in chicken G-protein alpha subunit gene
浙江大学学报. 农业与生命科学版, 2019 In order to research deeply the transcription and splicing situations of chicken G-protein alpha subunit gene (GNAS), we used 5´ and 3´ rapid-amplification cDNA end (RACE) technology to clone and sequence the chicken GNAS gene, and used quantitative ...
ZHANG Xuedong +6 more
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The role of the neuregulins in the nucleus [PDF]
, 2022 The neuregulins (NRGs) are ligands for receptor tyrosine kinases of the ErbB family. The NRG gene family consists of four members, NRG 1- 4 encoding different isoforms due to alternative splicing.
Wang, Ming
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Therapeutic Targeting of Alternative Splicing: A New Frontier in Cancer Treatment
Frontiers in Oncology, 2022 The ability for cells to harness alternative splicing enables them to diversify their proteome in order to carry out complex biological functions and adapt to external and internal stimuli. The spliceosome is the multiprotein-RNA complex charged with the
Anthony J. Murphy +3 more
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The spliceosome as a transposon sensor [PDF]
RNA Biology, 2013 The ability to distinguish self from non-self nucleic acids enables eukaryotes to suppress mobile elements and maintain genome integrity. In organisms from protist to human, this function is performed by RNA silencing pathways. There have been major advances in our understanding of the RNA silencing machinery, but the mechanisms by which these pathways
Dumesic, Phillip A, Madhani, Hiten D
openaire +4 more sources
Alternative Spliceosome Assembly Pathways Revealed by Single-Molecule Fluorescence Microscopy
Cell Reports, 2013 Removal of introns from nascent transcripts (pre-mRNAs) by the spliceosome is an essential step in eukaryotic gene expression. Previous studies have suggested that the earliest steps in spliceosome assembly in yeast are highly ordered and the stable ...
Inna Shcherbakova +7 more
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