Results 11 to 20 of about 6,327 (242)
PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects [PDF]
Nature CommunicationsThe carboxy-terminus of the spliceosomal protein PRPF8, which regulates the RNA helicase Brr2, is a hotspot for mutations causing retinitis pigmentosa-type 13, with unclear role in human splicing and tissue-specificity mechanism.
Robert Atkinson +31 more
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Regulation of Hair Follicle Growth and Development by Different Alternative Spliceosomes of FGF5 in Rabbits. [PDF]
Genes (Basel)This study investigated the regulatory effect of alternative spliceosomes of the fibroblast growth factor 5 (FGF5) gene on hair follicle (HF) growth and development in rabbits.
Sun S +9 more
europepmc +2 more sources
Spliceosomal immunophilins [PDF]
FEBS Letters, 2008 The spliceosome is a dynamic, macromolecular complex, which removes non‐protein‐coding introns from pre‐mRNA to form mature mRNA in a process known as splicing. This ribonucleoprotein assembly is comprised of five uridine‐rich small nuclear RNAs (snRNAs) as well as over 300 proteins.
Mesa, Annia +2 more
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Spliceosome Database: a tool for tracking components of the spliceosome [PDF]
Nucleic Acids Research, 2012 The spliceosome is the extremely complex macromolecular machine responsible for pre-mRNA splicing. It assembles from five U-rich small nuclear RNAs (snRNAs) and over 200 proteins in a highly dynamic fashion. One important challenge to studying the spliceosome is simply keeping track of all these proteins, a situation further complicated by the variety ...
Cvitkovic, Ivan, Jurica, Melissa S
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Spliceosomal intronogenesis [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Eukaryotic transcripts contain spliceosomal introns that need to be removed by pre-mRNA splicing. Although several models have been proposed to identify the mechanism of intron gain over the evolution of eukaryotes, they remain models due to a lack of experimental validation.
Sujin, Lee, Scott W, Stevens
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The 35S U5 snRNP Is Generated from the Activated Spliceosome during In vitro Splicing. [PDF]
PLoS ONE, 2015 Primary gene transcripts of eukaryotes contain introns, which are removed during processing by splicing machinery. Biochemical studies In vitro have identified a specific pathway in which introns are recognised and spliced out. This occurs by progressive
Olga V Makarova, Evgeny M Makarov
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Frontiers in Genetics, 2020 Splicing and alternative splicing of pre-mRNA are key sources in the formation of diversity in the human proteome. These processes have a central role in the regulation of the gene expression pathway.
Naama Sebbag-Sznajder +5 more
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Agronomy, 2021 The calmodulin-binding transcription activator (CAMTA), as one of the most distinctive families of transcription factors, plays an important role in plant growth and development and in the stress response.
Rong Gao +5 more
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Structural and Functional Insights into Human Nuclear Cyclophilins
Biomolecules, 2018 The peptidyl prolyl isomerases (PPI) of the cyclophilin type are distributed throughout human cells, including eight found solely in the nucleus. Nuclear cyclophilins are involved in complexes that regulate chromatin modification, transcription, and pre ...
Caroline Rajiv, Tara L. Davis
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The minor spliceosomal protein U11/U12-31K is an RNA chaperone crucial for U12 intron splicing and the development of dicot and monocot plants. [PDF]
PLoS ONE, 2012 U12 intron-specific spliceosomes contain U11 and U12 small nuclear ribonucleoproteins and mediate the removal of U12 introns from precursor-mRNAs. Among the several proteins unique to the U12-type spliceosomes, an Arabidopsis thaliana AtU11/U12-31K ...
Kyung Jin Kwak +6 more
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