Results 31 to 40 of about 225,555 (308)
Quantification of pre-mRNA escape rate and synergy in splicing [PDF]
, 2014 Splicing reactions generally combine high speed with accuracy. However, some of the pre-mRNAs escape the nucleus with a retained intron. Intron retention can control gene expression and increase proteome diversity.
Becskei, Attila +13 more
core +1 more source
Engineering splicing factors with designed specificities [PDF]
Nature Methods, 2009 Alternative splicing is generally regulated by trans-acting factors that specifically bind pre-mRNA to activate or inhibit the splicing reaction. This regulation is critical for normal gene expression, and dysregulation of splicing is closely associated with human diseases. Here we engineer artificial splicing factors by combining sequence-specific RNA-
Yang, Wang +3 more
openaire +2 more sources
Frontiers in Genetics, 2020 Accumulation of evidence has indicated a close relationship between alternative splicing (AS) and gastric cancer (GC), whereas systematic analyses of the differentially expressed AS events (DEAS) between GC and normal tissues are lacking.
Changwei Lin +6 more
doaj +1 more source
A trio of unique alternative splicing patterns : the splicing of tandem NAGNAG acceptors, transcription-start-site-dependent and mutually dependent cassette exons [PDF]
, 2008 With the rapid increase in the volume of genomic and transcript data in mouse and human, a diverse set of alternative splicing patterns can be discovered.
Chern, Tzu-Ming
core +1 more source
Control of 3' splice site selection by the yeast splicing factor Fyv6. [PDF]
ElifeABSTRACT Pre-mRNA splicing is catalyzed in two steps: 5ʹ splice site (SS) cleavage and exon ligation. A number of proteins transiently associate with spliceosomes to specifically impact these steps (1 st and 2 nd step factors).
Senn KA +5 more
europepmc +5 more sources
Multiple tandem splicing silencer elements suppress aberrant splicing within the long exon 26 of the human Apolipoprotein B gene. [PDF]
, 2013 : BACKGROUND: Apolipoprotein B (APOB) is an integral component of the chylomicron and the atherogenic lipoproteins LDL and Lp(a). Exon 26 of the APOB pre-mRNA is unusually long at 7,572 nt and is constitutively spliced.
Srirangalingam, U +5 more
core +1 more source
Splicing factor mutations in myelodysplasia [PDF]
International Journal of Hematology, 2012 Myelodysplastic syndromes (MDS) and related myeloid neoplasms are a heterogeneous group of myeloid neoplasms, which frequently terminate in acute myeloid leukemia (AML). During the past decade, a number of gene mutations have been identified in MDS.
openaire +2 more sources
PLoS Genetics, 2019 Gene expression dynamics can be measured in single living cells. Using a detectable transcriptionally active gene in living cells, we previously found that an mRNA undergoing several splicing events was retained at this gene after transcription until ...
Hodaya Hochberg-Laufer +5 more
doaj +1 more source
Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. [PDF]
PLoS Genetics, 2008 Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to detect
Sergio Barberan-Soler, Alan M Zahler
doaj +1 more source
The Role of Splicing Factors in Adipogenesis and Thermogenesis
Molecules and Cells, 2023 Obesity is a significant global health risk that can cause a range of serious metabolic problems, such as type 2 diabetes and cardiovascular diseases. Adipose tissue plays a pivotal role in regulating energy and lipid storage. New research has underlined the crucial role of splicing factors in the physiological and functional regulation of adipose ...
Yadanar Than Naing, Lei Sun
openaire +2 more sources