Results 11 to 20 of about 225,555 (308)
Splicing factor mutations and cancer. [PDF]
WIREs RNA, 2014 Recent advances in high-throughput sequencing technologies have unexpectedly revealed that somatic mutations of splicing factor genes frequently occurred in several types of hematological malignancies, including myelodysplastic syndromes, other myeloid ...
Yoshida, Kenichi, Ogawa, Seishi
core +4 more sources
An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts
RNA Biology, 2022 RNA splicing refers to a process by which introns of a pre-mRNA are excised and the exons at both ends are joined together. Chloroplast introns are inherently self-splicing ribozymes, but over time, they have lost self-splicing ability due to the ...
Xuemei Wang +4 more
doaj +3 more sources
Splicing-factor alterations in cancers [PDF]
RNA, 2016 Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery.
Anczuków, Olga +3 more
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Alternative Splicing Events and Splicing Factors Are Prognostic in Adrenocortical Carcinoma [PDF]
Frontiers in Genetics, 2020 Alternative splicing is involved in the pathogenesis of human diseases, including cancer. Here, we investigated the potential application of alternative splicing events (ASEs) and splicing factors (SFs) in the prognosis of adrenocortical carcinoma (ACC).
Jian Lv +5 more
doaj +3 more sources
Modulation of Splicing Factor Function and Alternative Splicing Outcomes
, 2022 Indiana University-Purdue University Indianapolis (IUPUI)Alternative RNA splicing is an important means of genetic control and transcriptome diversity. Alternative splicing events are frequently studied independently, and coordinated splicing controlled ...
Chen, Steven Xiwei
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CRISPR artificial splicing factors [PDF]
Nature Communications, 2020 Abstract Alternative splicing allows expression of mRNA isoforms from a single gene, expanding the diversity of the proteome. Its prevalence in normal biological and disease processes warrant precise tools for modulation.
Menghan Du +4 more
openaire +4 more sources
Processive phosphorylation of alternative splicing factor/splicing factor 2 [PDF]
Proceedings of the National Academy of Sciences, 2003 SR proteins, named for their multiple arginine/serine (RS) dipeptide repeats, are critical components of the spliceosome, influencing both constitutive and alternative splicing of pre-mRNA. SR protein function is regulated through phosphorylation of their RS domains by multiple kinases, including a family of evolutionarily conserved SR protein-specific
Brandon E, Aubol +7 more
openaire +2 more sources
Splicing factor mutations in hematologic malignancies [PDF]
Blood, 2021 Abstract Mutations in genes encoding RNA splicing factors were discovered nearly 10 years ago and are now understood to be among the most recurrent genetic abnormalities in patients with all forms of myeloid neoplasms and several types of lymphoproliferative disorders, as well as subjects with clonal hematopoiesis.
Sisi Chen +2 more
openaire +2 more sources
Mechanisms of non-coding RNA-modulated alternative splicing in cancer
RNA Biology, 2022 Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions.
Xiaolin Wang +6 more
doaj +1 more source
A mutation in a splicing factor that causes retinitis pigmentosa has a transcriptome-wide effect on mRNA splicing [PDF]
, 2014 Background: Substantial progress has been made in the identification of sequence elements that control mRNA splicing and the genetic variants in these elements that alter mRNA splicing (referred to as splicing quantitative trait loci – sQTLs).
Ramesar, Raj +7 more
core +1 more source