Results 11 to 20 of about 215,019 (165)

Splicing-factor alterations in cancers [PDF]

RNA, 2016
Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery. This review summarizes our current understanding of the role of splicing-factor alterations in human cancers.
Anczuków, Olga, Krainer, Adrian R
openaire   +2 more sources

SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity

Nature Communications, 2021
Splicing factor PTBP1 is reported to promote oncogenic functions in glioblastoma (GBM). Here the authors show splicing factor SON upregulates PTBP1 expression while supresses its paralog PTBP2 through alternative splicing and the inhibition of SON ...
Jung-Hyun Kim, Kyuho Jeong, Jianfeng Li, James M. Murphy, Lana Vukadin, Joshua K. Stone, Alexander Richard, Johnny Tran, G. Yancey Gillespie, Erik K. Flemington, Robert W. Sobol, Ssang-Teak Steve Lim, Eun-Young Erin Ahn   +12 more
doaj   +1 more source

Splicing factor mutations and cancer [PDF]

WIREs RNA, 2014
Recent advances in high‐throughput sequencing technologies have unexpectedly revealed that somatic mutations of splicing factor genes frequently occurred in several types of hematological malignancies, including myelodysplastic syndromes, other myeloid neoplasms, and chronic lymphocytic leukemia.
Yoshida, Kenichi, Ogawa, Seishi
openaire   +2 more sources

RNA-Binding Proteins Hold Key Roles in Function, Dysfunction, and Disease

Biology, 2021
RNA-binding proteins (RBPs) are multi-faceted proteins in the regulation of RNA or its RNA splicing, localisation, stability, and translation. Amassing proof from many recent and dedicated studies reinforces the perception of RBPs exerting control ...
Sophia Kelaini, Celine Chan, Victoria A Cornelius, Andriana Margariti   +3 more
doaj   +1 more source

Comprehensive Analysis of Splicing Factor and Alternative Splicing Event to Construct Subtype-Specific Prognosis-Predicting Models for Breast Cancer

Frontiers in Genetics, 2021
Recent evidence suggests that splicing factors (SFs) and alternative splicing (AS) play important roles in cancer progression. We constructed four SF-risk-models using 12 survival-related SFs.
He Zhang, He Zhang, He Zhang, He Zhang, Baoai Han, Baoai Han, Baoai Han, Baoai Han, Xingxing Han, Xingxing Han, Xingxing Han, Xingxing Han, Yuying Zhu, Yuying Zhu, Yuying Zhu, Yuying Zhu, Hui Liu, Hui Liu, Hui Liu, Hui Liu, Zhiyong Wang, Zhiyong Wang, Zhiyong Wang, Zhiyong Wang, Yanfen Cui, Yanfen Cui, Yanfen Cui, Yanfen Cui, Ran Tian, Ran Tian, Ran Tian, Ran Tian, Zicong Gao, Zicong Gao, Zicong Gao, Zicong Gao, Ruinan Tian, Ruinan Tian, Ruinan Tian, Ruinan Tian, Sixin Ren, Sixin Ren, Sixin Ren, Sixin Ren, Xiaoyan Zuo, Xiaoyan Zuo, Xiaoyan Zuo, Xiaoyan Zuo, Jianfei Tian, Jianfei Tian, Jianfei Tian, Jianfei Tian, Fei Zhang, Fei Zhang, Fei Zhang, Fei Zhang, Ruifang Niu, Ruifang Niu, Ruifang Niu, Ruifang Niu   +59 more
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Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer

BMC Cancer, 2022
Background Alternative RNA splicing is widely dysregulated in cancers including lung adenocarcinoma, where aberrant splicing events are frequently caused by somatic splice site mutations or somatic mutations of splicing factor genes.
April Lo, Maria McSharry, Alice H. Berger   +2 more
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SWELLMAP 2, a phyB-Interacting Splicing Factor, Negatively Regulates Seedling Photomorphogenesis in Arabidopsis

Frontiers in Plant Science, 2022
Light-triggered transcriptome reprogramming is critical for promoting photomorphogenesis in Arabidopsis seedlings. Nonetheless, recent studies have shed light on the importance of alternative pre-mRNA splicing (AS) in photomorphogenesis.
Tingting Yan, Tingting Yan, Yueqin Heng, Wenwei Wang, Jian Li, Xing Wang Deng, Xing Wang Deng   +6 more
doaj   +1 more source

Mechanisms of non-coding RNA-modulated alternative splicing in cancer

RNA Biology, 2022
Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions.
Xiaolin Wang, Jinghan Hua, Jingxin Li, Jiahui Zhang, Emmanuel Enoch Dzakah, Guozhen Cao, Wenchu Lin   +6 more
doaj   +1 more source

Replication stress signaling is a therapeutic target in myelodysplastic syndromes with splicing factor mutations

Haematologica, 2020
Somatic mutations in genes coding for splicing factors, e.g., SF3B1, U2AF1, SRSF2, and others are found in approximately 50% of patients with myelodysplastic syndromes (MDS).
Johanna Flach, Johann-Christoph Jann, Antje Knaflic, Vladimir Riabov, Alexander Streuer, Eva Altrock, Qingyu Xu, Nanni Schmitt, Julia Obländer, Verena Nowak, Justine Danner, Arwin Mehralivand, Franziska Hofmann, Iris Palme, Ahmed Jawhar, Patrick Wuchter, Georgia Metzgeroth, Florian Nolte, Wolf-Karsten Hofmann, Daniel Nowak   +19 more
doaj   +1 more source

Comprehensive Analysis of Prognostic Alternative Splicing Signature Reveals Recurrence Predictor for Papillary Thyroid Cancer

Frontiers in Oncology, 2021
BackgroundAlternative splicing (AS) plays a key role in the diversity of proteins and is closely associated with tumorigenicity. The aim of this study was to systemically analyze RNA alternative splicing (AS) and identify its prognostic value for ...
Mian Liu, Rooh Afza Khushbu, Pei Chen, Hui-Yu Hu, Neng Tang, Deng-jie Ou-yang, Bo Wei, Ya-xin Zhao, Peng Huang, Peng Huang, Shi Chang, Shi Chang, Shi Chang   +12 more
doaj   +1 more source