Results 11 to 20 of about 369,265 (299)
Splicing-factor alterations in cancers [PDF]
RNA, 2016 Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery.
Anczukow, O., Krainer, A. R.
core +4 more sources
PLoS ONE, 2017 More than 60% of myeloid dysplasia syndrome (MDS) contains mutations in genes encoding for splicing factors such as SF3B1, U2AF, SRSF2 and ZRSR2. Mutations in SF3B1 are associated with 80% cases of refractory anemia with ring sideroblast (RARS), a ...
Shuiling Jin +9 more
doaj +4 more sources
Splicing factor SRSF6 mediates pleural fibrosis [PDF]
JCI Insight, 2021 Pleural fibrosis is defined as an excessive deposition of extracellular matrix that results in destruction of the normal pleural tissue architecture and compromised function.
Li-Mei Liang +15 more
doaj +3 more sources
CRISPR artificial splicing factors [PDF]
Nature Communications, 2020 Abstract Alternative splicing allows expression of mRNA isoforms from a single gene, expanding the diversity of the proteome. Its prevalence in normal biological and disease processes warrant precise tools for modulation.
Menghan Du +4 more
openaire +5 more sources
Processive phosphorylation of alternative splicing factor/splicing factor 2 [PDF]
Proceedings of the National Academy of Sciences, 2003 SR proteins, named for their multiple arginine/serine (RS) dipeptide repeats, are critical components of the spliceosome, influencing both constitutive and alternative splicing of pre-mRNA. SR protein function is regulated through phosphorylation of their RS domains by multiple kinases, including a family of evolutionarily conserved SR protein-specific
Brandon E, Aubol +7 more
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Splicing factor mutations in hematologic malignancies [PDF]
Blood, 2021 Abstract Mutations in genes encoding RNA splicing factors were discovered nearly 10 years ago and are now understood to be among the most recurrent genetic abnormalities in patients with all forms of myeloid neoplasms and several types of lymphoproliferative disorders, as well as subjects with clonal hematopoiesis.
Sisi Chen +2 more
openaire +2 more sources
Splicing factor SRSF2-centric gene regulation [PDF]
International Journal of Biological Sciences, 2021 Serine/arginine-rich splicing factor 2 (SRSF2) is a splicing factor that is widely expressed in a variety of mammalian cell types. Increasing evidence has confirmed that SRSF2 plays vital roles in a number of biological and pathological processes.
Li, Kun, Wang, Ziqiang
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Splicing factor mutations and cancer [PDF]
WIREs RNA, 2014 Recent advances in highâthroughput sequencing technologies have unexpectedly revealed that somatic mutations of splicing factor genes frequently occurred in several types of hematological malignancies, including myelodysplastic syndromes, other myeloid neoplasms, and chronic lymphocytic leukemia.
Yoshida, Kenichi, Ogawa, Seishi
openaire +2 more sources
Frontiers in Plant Science, 2022 Light-triggered transcriptome reprogramming is critical for promoting photomorphogenesis in Arabidopsis seedlings. Nonetheless, recent studies have shed light on the importance of alternative pre-mRNA splicing (AS) in photomorphogenesis.
Tingting Yan +6 more
doaj +1 more source
An overview of RNA splicing and functioning of splicing factors in land plant chloroplasts
RNA Biology, 2022 RNA splicing refers to a process by which introns of a pre-mRNA are excised and the exons at both ends are joined together. Chloroplast introns are inherently self-splicing ribozymes, but over time, they have lost self-splicing ability due to the ...
Xuemei Wang +4 more
doaj +1 more source