Results 41 to 50 of about 3,932,181 (346)

The role of alternative splicing in cancer: From oncogenesis to drug resistance.

Drug resistance updates, 2020
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-mRNA are removed and protein-coding segments are assembled in diverse combinations, ultimately giving rise to proteins with distinct or even opposing functions.
R. Sciarrillo, A. Wojtuszkiewicz, Y. Assaraf, G. Jansen, G. Kaspers, E. Giovannetti, J. Cloos   +6 more
semanticscholar   +1 more source

Alternative splicing and disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
Almost all protein-coding genes are spliced and their majority is alternatively spliced. Alternative splicing is a key element in eukaryotic gene expression that increases the coding capacity of the human genome and an increasing number of examples illustrates that the selection of wrong splice sites causes human disease.
Tazi, Jamal, Bakkour, Nadia, Stamm, Stefan   +2 more
openaire   +3 more sources

Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

Nature Communications, 2020
While most monogenic diseases are caused by loss or reduction of protein function, the need for technologies that can selectively increase levels of protein in native tissues remains.
K. Lim, Zhou Han, H. Y. Jeon, Jacob Kach, Enxuan Jing, Sebastien M. Weyn-Vanhentenryck, Mikaela Downs, Anna Corrionero, Raymond Oh, Juergen Scharner, Aditya Venkatesh, Sophina Ji, G. Liau, B. Ticho, H. Nash, I. Aznarez   +15 more
semanticscholar   +1 more source

Mapping splice QTLs reveals distinct transcriptional and post-transcriptional regulatory variation of gene expression and identifies putative alternative splicing variation mediating complex trait variation in pigs

BMC Genomics, 2023
Background Alternative splicing is an important step in gene expression, generating multiple isoforms for the same genes and greatly expanding the diversity of proteomes.
Fei Zhang, Deborah Velez-Irizarry, Catherine W. Ernst, Wen Huang   +3 more
doaj   +1 more source

DEDB: a database of Drosophila melanogaster exons in splicing graph form

BMC Bioinformatics, 2004
Background A wealth of quality genomic and mRNA/EST sequences in recent years has provided the data required for large-scale genome-wide analysis of alternative splicing.
Tan Tin, Lee Bernett TK, Ranganathan Shoba   +2 more
doaj   +1 more source

Serine/arginine-rich splicing factors: the bridge linking alternative splicing and cancer

International Journal on Biological Sciences, 2020
The serine/arginine-rich splicing factors (SRs) belong to the serine arginine-rich protein family, which plays an extremely important role in the splicing process of precursor RNA.
Xiang Zheng, Qiu Peng, Lujuan Wang, Xuemei Zhang, Lili Huang, Jia Wang, Zailong Qin   +6 more
semanticscholar   +1 more source

Alternative splicing is required for stage differentiation in malaria parasites

Genome Biology, 2019
Background In multicellular organisms, alternative splicing is central to tissue differentiation and identity. Unicellular protists lack multicellular tissue but differentiate into variable cell types during their life cycles.
Lee M. Yeoh, Christopher D. Goodman, Vanessa Mollard, Emma McHugh, V. Vern Lee, Angelika Sturm, Anton Cozijnsen, Geoffrey I. McFadden, Stuart A. Ralph   +8 more
doaj   +1 more source

The implications of alternative pre-mRNA splicing in cell signal transduction

Experimental and Molecular Medicine, 2023
Cells produce multiple mRNAs through alternative splicing, which ensures proteome diversity. Because most human genes undergo alternative splicing, key components of signal transduction pathways are no exception.
Sunkyung Choi, Namjoon Cho, Kee K. Kim
doaj   +1 more source

The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing

Nature Communications, 2020
Alternative splicing has been shown to causally contribute to the epithelial–mesenchymal transition (EMT) and tumor metastasis. However, the scope of splicing factors that govern alternative splicing in these processes remains largely unexplored. Here we
Xiaohui Hu, S. E. Harvey, Rong Zheng, Jingyi Lyu, Caitlin L. Grzeskowiak, E. Powell, H. Piwnica-Worms, K. Scott, Chonghui Cheng   +8 more
semanticscholar   +1 more source

Hypoxia-induced alternative splicing in endothelial cells

, 2012
Background: Adaptation to low oxygen by changing gene expression is vitally important for cell survival and tissue development. The sprouting of new blood vessels, initiated from endothelial cells, restores the oxygen supply of ischemic tissues.
Weigand, Julia E., Julia E. Weigand (17017), Julia E Weigand, Pascal Gellert, Stefanie Dimmeler, Dimmeler, Stefanie, Jes-Niels Boeckel (145707), Pascal Gellert (145710), Gellert, Pascal, Jes-Niels Boeckel, Stefanie Dimmeler (134234), Boeckel, Jes-Niels   +11 more
core   +1 more source