Results 21 to 30 of about 172,920 (260)

Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. [PDF]

PLoS Genetics, 2008
Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to detect
Sergio Barberan-Soler, Alan M Zahler
doaj   +1 more source

The neurogenetics of alternative splicing [PDF]

Nature Reviews Neuroscience, 2016
Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal ...
Celine K, Vuong, Douglas L, Black, Sika, Zheng   +2 more
openaire   +2 more sources

SIRT1 Involved in the Regulation of Alternative Splicing Affects the DNA Damage Response in Neural Stem Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR).
Guangming Wang, Fangce Wang, Jie Ren, Yue Qiu, Wenjun Zhang, Shane Gao, Danjing Yang, Zhigang Wang, Aibin Liang, Zhengliang Gao, Jun Xu   +10 more
doaj   +1 more source

Alternative splicing in breast cancer

Journal of Bio-X Research, 2023
Alternative splicing allows a gene to produce multiple proteins and is the main source of human proteome diversity. Aberrant regulation of alternative splicing produces proteins with different structures and can lead to altered protein function ...
Xin Wen, Ze Yan, Li Sha
doaj   +1 more source

Transcriptome Bioinformatical Analysis of Vertebrate Stages of Schistosoma japonicum Reveals Alternative Splicing Events. [PDF]

PLoS ONE, 2015
Alternative splicing is a molecular process that contributes greatly to the diversification of proteome and to gene functions. Understanding the mechanisms of stage-specific alternative splicing can provide a better understanding of the development of ...
Xinye Wang, Xindong Xu, Xingyu Lu, Yuanbin Zhang, Weiqing Pan   +4 more
doaj   +1 more source

Function of alternative splicing [PDF]

Gene, 2013
Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review the functions of alternative splicing events that have been experimentally determined. The overall function of alternative splicing is to increase the diversity of mRNAs expressed from the genome. Alternative splicing changes proteins encoded by mRNAs, which has
Olga, Kelemen, Paolo, Convertini, Zhaiyi, Zhang, Yuan, Wen, Manli, Shen, Marina, Falaleeva, Stefan, Stamm   +6 more
openaire   +2 more sources

Alternative Splicing in Angiogenesis

International Journal of Molecular Sciences, 2019
Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to ...
Elizabeth Bowler, Sebastian Oltean
openaire   +3 more sources

Significance of alternative splicing in cancer cells

Chinese Medical Journal, 2020
. Objective. Alternative splicing can generate various structural and functional protein isoforms. Recently, accumulating evidence shows a relationship between alternative splicing and cancer.
Fei Qi, Yong Li, Xue Yang, Yan-Ping Wu, Lian-Jun Lin, Xin-Min Liu, Li-Min Chen   +6 more
doaj   +1 more source

Alternative Splicing in CKD [PDF]

Journal of the American Society of Nephrology, 2016
Alternative splicing (AS) has emerged in the postgenomic era as one of the main drivers of proteome diversity, with ≥94% of multiexon genes alternatively spliced in humans. AS is therefore one of the main control mechanisms for cell phenotype, and is a process deregulated in disease.
Stevens, Megan, Oltean, Sebastian
openaire   +3 more sources

Alternative splicing and disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
Almost all protein-coding genes are spliced and their majority is alternatively spliced. Alternative splicing is a key element in eukaryotic gene expression that increases the coding capacity of the human genome and an increasing number of examples illustrates that the selection of wrong splice sites causes human disease.
Tazi, Jamal, Bakkour, Nadia, Stamm, Stefan   +2 more
openaire   +3 more sources