Results 21 to 30 of about 3,932,181 (346)
Alternative splicing during mammalian organ development
Nature Genetics, 2021 Alternative splicing (AS) is pervasive in mammalian genomes, yet cross-species comparisons have been largely restricted to adult tissues and the functionality of most AS events remains unclear.
P. Mazin +3 more
semanticscholar +1 more source
Noncoding RNAs regulate alternative splicing in Cancer
Journal of experimental & clinical cancer research : CR, 2021 AS (alternative splicing) is a fundamental process by which a gene can generate multiple distinct mRNA transcripts to increase protein diversity.
Yunze Liu +6 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Circular RNAs (circRNAs) play increasingly appreciated gene-regulatory roles in the process of human tumorigenesis. Our results demonstrated that circURI1 expression levels were significantly increased in gastric cancer (GC) compared to ...
Xiaolin Wang +11 more
semanticscholar +1 more source
Alternative splicing and disease [PDF]
RNA Biology, 2008 Splicing is a molecular mechanism, by which introns are removed from an mRNA precursor and exons are ligated to form a mature mRNA. Mutations that cause defects in the splicing mechanism are known to be responsible for many diseases, including cystic fibrosis and familial dysautonomia.
Eddo, Kim, Amir, Goren, Gil, Ast
openaire +2 more sources
Mechanisms of Alternative Pre-Messenger RNA Splicing
Annual Review of Biochemistry, 2003 Douglas L Black
exaly +2 more sources
SRRM2 organizes splicing condensates to regulate alternative splicing
bioRxiv, 2022 SRRM2 is a nuclear-speckle marker containing multiple disordered domains, whose dysfunction is associated with several human diseases. Using mainly EGFP-SRRM2 knock-in HEK293T cells, we show that SRRM2 forms biomolecular condensates satisfying most ...
Shaohai Xu +5 more
semanticscholar +1 more source
Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. [PDF]
PLoS Genetics, 2008 Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to detect
Sergio Barberan-Soler, Alan M Zahler
doaj +1 more source
The neurogenetics of alternative splicing [PDF]
Nature Reviews Neuroscience, 2016 Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal ...
Celine K, Vuong +2 more
openaire +2 more sources
Alternative splicing in breast cancer
Journal of Bio-X Research, 2023 Alternative splicing allows a gene to produce multiple proteins and is the main source of human proteome diversity. Aberrant regulation of alternative splicing produces proteins with different structures and can lead to altered protein function ...
Xin Wen, Ze Yan, Li Sha
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR).
Guangming Wang +10 more
doaj +1 more source