This study investigates the cis‐element in pre‐mRNA recognized by the polyadenylation CFII complex. It elucidates how the CFII complex recognizes the consensus cis‐element downstream of the poly(A) site for pre‐mRNA alternative polyadenylation. This comprehensive research provides novel insights into the interaction between 3′ end processing complexes ...
Ying Cao +13 more
wiley +1 more source
Circular RNA Rftn1 Promotes Cardiac Hypertrophy In Vitro and In Vivo by Sponging miRNA-1192 to Upregulate Tripartite Motif Protein 25 and 41. [PDF]
Liu G +6 more
europepmc +1 more source
Human monoamine oxidase A and B genes exhibit identical exon-intron organization. [PDF]
Joseph Grimsby +4 more
openalex +1 more source
Modeling Control of Invasive Fire Ants by Gene Drive
The fire ant Solenopsis invicta is characterized by exceptional invasive capabilities, rendering conventional control ineffective. Here, we explore the use of homing suppression gene drive in fire ants by developing a spatially explicit model. Overall, these results show that target population suppression requires an extended time scale, but that gene ...
Yiran Liu +3 more
wiley +1 more source
Intersecting Pathologies: <i>COL1A1</i>-Related Syndrome in the Setting of Childhood-Onset Hypopituitarism: Case Report and Literature Review. [PDF]
Pelineagră OE +9 more
europepmc +1 more source
Draper is evolutionarily conserved across most insect species. Loss of Draper inhibits autophagy activation, delaying middle silk gland degradation in the silkworm during metamorphosis. Draper interacts with autophagy ‐ related protein 3 (ATG3) to orchestrate autophagosome formation—a process essential for silk gland degradation during the larval‐pupal
Shiyu Zou +9 more
wiley +1 more source
Nonequivalence of Zfp423 premature termination codons in mice. [PDF]
Concepcion D +3 more
europepmc +1 more source
Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity [PDF]
openalex +1 more source
CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target
CircSMEK1 is downregulated in MASH/HCC and predicts poor prognosis. It suppresses tumor progression by promoting hnRNPK ubiquitination and inhibiting the IGF2/PI3K/AKT axis, while its loss activates immunosuppressive cancer‐associated fibroblasts. Serum circSMEK1 serves as a non‐invasive diagnostic biomarker, and its restoration potently inhibits HCC ...
Peilan Guo +15 more
wiley +1 more source

