Results 211 to 220 of about 838,049 (387)

A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation

Science, 2019
S. Fica, C. Oubridge, M. E. Wilkinson, A. Newman, K. Nagai   +4 more
semanticscholar   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source

The exon junction complex coordinates the cotranscriptional inclusion of blocks of neighboring exons. [PDF]

Genes Dev
Bergfort A, Gordon JM, Gazzara MR, Hung CT, Lee B, Barash Y, Neugebauer KM.   +6 more
europepmc   +1 more source

Data on the exon-intron organization of genes coding for B-cell receptor-like proteins

, 2017
Sergey Y. Morozov, А.В. Панкратенко, Anastasia K. Atabekova, Andrey G. Solovyev   +3 more
openalex   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Effects of exon sequences on splicing of model pre-mRNA substrates in vitro.

, 1996
Zbigniew Domiński, R Kole
openalex   +2 more sources

Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors.

Cancer Discovery, 2015
G. Frampton, Siraj M. Ali, M. Rosenzweig, J. Chmielecki, Xinyuan Lu, T. Bauer, M. Akimov, J. Bufill, Carrie Lee, D. Jentz, R. Hoover, S. Ou, R. Salgia, Tim Brennan, Z. Chalmers, S. Jaeger, A. Huang, J. Elvin, R. Erlich, Alex M. Fichtenholtz, Kyle Gowen, J. Greenbowe, Adrienne Johnson, D. Khaira, Caitlin McMahon, Eric M. Sanford, S. Roels, Jared White, J. Greshock, R. Schlegel, D. Lipson, R. Yelensky, D. Morosini, J. Ross, E. Collisson, M. Peters, P. Stephens, V. Miller   +37 more
semanticscholar   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

A therapeutic antisense oligonucleotide encompassing 2'-<i>O</i>-methoxyethyl modification triggers unique perturbation of the transcriptome. [PDF]

NAR Mol Med
Ottesen EW, Murzyn WA, Kaas RL, Bertrand KJ, Payne JL, Singh RN.   +5 more
europepmc   +1 more source

Characterization Ofp53 Gene Sequence in Exons 5-8 of the Western Mosquito Fish, Gambusia Affinis.

, 1998
Neeraja Erraguntla, Neeraja Erraguntla
openalex   +2 more sources