Results 251 to 260 of about 838,049 (387)

Data_Sheet_1_Resolvin E1-ChemR23 Axis Regulates the Hepatic Metabolic and Inflammatory Transcriptional Landscape in Obesity at the Whole Genome and Exon Level.XLSX

, 2021
Abrar E. Al-Shaer (6580940), Anandita Pal (11876804), Saame Raza Shaikh (4178581)   +2 more
openalex   +2 more sources

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.

Cancer Cell, 2015
Eunhee Kim, J. Ilagan, Yang Liang, G. M. Daubner, Stanley C. Lee, Aravind Ramakrishnan, Aravind Ramakrishnan, Yue Li, Y. R. Chung, J. Micol, Michele E. Murphy, Hana Cho, Min Kyung Kim, Ahmad S. Zebari, Shlomzion Aumann, Christopher Y. Park, S. Buonamici, Peter G. Smith, H. J. Deeg, H. J. Deeg, Camille Lobry, Camille Lobry, I. Aifantis, Y. Modis, Y. Modis, F. Allain, Stephanie Halene, R. Bradley, O. Abdel-Wahab   +28 more
semanticscholar   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Exon-level <i>TP53</i> alterations and PD-L1 expression identified by pretreatment NGS stratify survival in <i>EGFR</i>-mutant non-small cell lung cancer treated with first-line osimertinib. [PDF]

Transl Lung Cancer Res
Kim SE, Kim Y, Yoon DK, Park H, Park KS, Kim D, Hwang HS, Ahn B, Park JE, Kim SW, Jang SJ, Yoon S, Lee HS, Lee DH.   +13 more
europepmc   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Prolonged survival in EGFR exon 20 insertion mutant lung adenocarcinoma: case report of sequential osimertinib and furmonertinib with research trend analysis. [PDF]

Front Med (Lausanne)
Lu Y, Zhao R, Wang N, Zhao J, Huang N, Al-Danakh A, Liu H, Gao P.   +7 more
europepmc   +1 more source

How we diagnose and manage altered oxygen affinity hemoglobin variants: Lest we forget JAK2 Exon 12 mutation [PDF]

, 2019
Ankit Mangla, Nikki Agarwal
openalex   +1 more source

Data from Co-occurring Alterations in the RAS–MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer

, 2023
Julia Rotow, Philippe Gui, Wei Wu, Victoria M. Raymond, Richard B. Lanman, Frederic J. Kaye, Nir Peled, Ferran Fece de la Cruz, Brandon Nadres, Ryan B. Corcoran, Iwei Yeh, Boris C. Bastian, Petr Starostik, Kimberly J. Newsom, Victor Olivas, Alexander M. Wolff, James S. Fraser, Eric A. Collisson, Caroline E. McCoach, D. Ross Camidge, J. A. de Freitas Pacheco, Lyudmila Bazhenova, Tianhong Li, Trever G. Bivona, Collin M. Blakely   +24 more
openalex   +1 more source

Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth.

Journal of Clinical Investigation, 2016
M. Dewaele, Tommaso Tabaglio, K. Willekens, M. Bezzi, S. Teo, Diana H. P. Low, Cheryl M. Koh, F. Rambow, M. Fiers, A. Rogiers, E. Radaelli, M. Al-Haddawi, Soo-Yong Tan, Els Hermans, F. Amant, Hualong Yan, Manikandan Lakshmanan, Ratnacaram Chandrahaas Koumar, S. Lim, Frederick A. Derheimer, R. Campbell, Zahid Bonday, V. Tergaonkar, M. Shackleton, C. Blattner, J. Marine, E. Guccione   +26 more
semanticscholar   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source