Results 261 to 270 of about 395,522 (295)

Mediterranean fever gene variants may prevent the development of lupus nephritis in Japanese patients with systemic lupus erythematosus. [PDF]

Front Immunol
Endo Y, Koga T, Mohamed L, Tsuji Y, Umeda M, Hayashi H, Kishino T, Kawakami A.   +7 more
europepmc   +1 more source

Viral‐Directed Augmentation of Kupffer Cell Cross‐Presentation Provokes Antitumor Immunity Against Liver Metastasis

Advanced Science, EarlyView.
Targeting Kupffer cells (KC) with a single intravenous infusion of the oncolytic virus VSV‐M51R rather than VSV‐WT induces effective tumor regression in various types of liver metastatic cancers in mice. VSV‐M51R promotes KC proliferation and enhances their antigen cross‐presentation capacity without compromising viability, leading to the induction of ...
Chen Chen, Qing Zhang, Jiajia Li, Xia Zhou, Daxing Gao, Lu Li, Dabing Huang, Jizhou Wang, Zhutian Zeng   +8 more
wiley   +1 more source

Association Between DNA Methylation of <i>MTHFR</i> and Diabetic Kidney Disease. [PDF]

J Diabetes Res
Deng G, Feng Z, Kong X, Gao P, Jiang Y, Liu Y, Zhao M, Ma L.   +7 more
europepmc   +1 more source

A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness

Advanced Science, EarlyView.
This study identifies a sub‐circuit within the circadian pacemaker suprachiasmatic nucleus (SCN) that promotes arousal. This sub‐circuit is labeled by the clock output molecule mWAKE, which suppresses its excitability in a time‐dependent manner. mWAKE‐expressing cells in the SCN (SCNmWAKE cells) project to the subparaventricular zone (SPZ) to mediate ...
Qiang Liu, Sang Soo Lee, Jiali Xiong, Shahin Ahmadi, Benjamin J. Bell, Mehmet F. Keles, Mark N. Wu   +6 more
wiley   +1 more source

A comprehensive splicing characterization of COL4A5 mutations and prognostic significance in a single cohort with X-linked alport syndrome. [PDF]

Front Genet
Li H, Zhang S, Zhou W, Wang C, Zhu C, Zhao S, Zhao F, Jia Z, Zhang A, Zheng B, Ding G.   +10 more
europepmc   +1 more source

Co‐Selection of Low Cadmium Accumulation and High Yield During Tomato Improvement

Advanced Science, EarlyView.
This study finds that large‐fruited tomatoes accumulate less cadmium (Cd) compared to wild tomatoes and cherry tomatoes. This is because, during the improvement process of tomato, the low‐Cd allele LCT1A and the large fruit allele fw3.2T are closely linked, leading to a co‐selection event.
Xingyu Zhang, Mei Qing, Haobo Xu, Jinbao Tao, Fangman Li, Pingfei Ge, Yang Yang, Wenqian Wang, Yongen Lu, Donald Grierson, Zhibiao Ye, Yuyang Zhang   +11 more
wiley   +1 more source

Ocean acidification induces changes in circadian alternative splicing profiles in a coral reef fish. [PDF]

Sci Rep
Suresh S, Jarrold M, Ravasi T, Munday PL, Schunter C.   +4 more
europepmc   +1 more source

GmSop20 Functions as a Key Coordinator of the Oil‐To‐Protein Ratio in Soybean Seeds

Advanced Science, EarlyView.
This study investigates the seed oil‐to‐protein ratio as a comprehensive quality metric and identifies GmSop20 as a crucial regulatory gene through forward genetics methodologies. By integrating GmSop20 with superior haplotypes and using gene editing/overexpression, new strategies are provided for precisely tuning the seed oil‐to‐protein ratio, thereby
Haowei Zheng, Xinkang Feng, Longlong Wang, Wentao Shao, Shiyu Guo, Duo Zhao, Jiajia Li, Long Yan, Long Miao, Bincheng Sun, Huihui Gao, Hongmei Qiu, Yu Hu, Linlin Kong, Robert M. Stupar, Ying‐hui Li, Li‐juan Qiu, Xiaobo Wang   +17 more
wiley   +1 more source

Duchenne Muscular Dystrophy: Integrating Current Clinical Practice with Future Therapeutic and Diagnostic Horizons. [PDF]

Int J Mol Sci
Montagna C, Maiani E, Pieroni L, Consalvi S.   +3 more
europepmc   +1 more source

BRD4 Signaling Maintains the Differentiated State of β Cells

Advanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun, Mengmeng Yang, Hualin Liu, Hongkai Zhao, Jiamu Chen, Qincheng Qiao, Siyue Li, Chenglong Yu, Jingru Qu, Ying Zou, Tixiao Wang, Jidong Liu, Lei Zhao, Huihui Tian, Tao Huang, Manna Zhang, Li Chen, Ruxing Zhao, Yuanyuan Du, Xinguo Hou   +22 more
wiley   +1 more source