Results 261 to 270 of about 838,049 (387)

Serum markers for prognostic value of EGFR-TKI in lung adenocarcinoma with bone metastases: a retrospective study. [PDF]

PeerJ
Li J, Wang S, Deng Z, Zhang L, Liu M, Luo Y, Guo Y, Liu P, Liu C.   +8 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Association Between PD-L1 Expression and Interstitial Lung Disease Risk in EGFR-mutant NSCLC Treated With EGFR-TKIs. [PDF]

In Vivo
Takahara Y, Abe R, Nagae S, Tanaka T, Ishige Y, Shionoya I, Yamamura K, Nojiri M, Iguchi M.   +8 more
europepmc   +1 more source

Exon [PDF]

, 2018
openaire   +2 more sources

A novel splicing graph allows a direct comparison between exon-based and splice junction-based approaches to alternative splicing detection [PDF]

Jelard Aquino, Daniel Witoslawski, Steve Park, Jessica Holder, Amei Amei, Mira Han   +5 more
openalex   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

RNA-binding proteins connect Exon usage to the chromatin. [PDF]

NAR Genom Bioinform
Robertson H, Do HTT, Helms V.
europepmc   +1 more source

PUS7-dependent Ψ reshapes specific synaptic gene exons to facilitate fear extinction memory formation [PDF]

Rong Liu, Yuhan Dong, Zhipeng Gao, Jichun Shi, Ziyue Xu, Junhui Liu, Gaomeng Luo, Shengda Ye, Feiyang Zhang, Hongyu Xu, Xiang Li, Sha Liu, Wei Wei   +12 more
openalex   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Detection of Expressed <i>Otx</i> mRNA Isoforms in Sea Urchins by Mapping NGS Reads to Single-Gene/Transcript Sequences. [PDF]

Biology (Basel)
Maiorova MA, Kipryushina YO, Yakovlev KV.   +2 more
europepmc   +1 more source