Results 291 to 300 of about 667,667 (355)

HTGTS‐TCR‐Seq for Profiling of Mouse and Human T‐Cell Receptor α and β Gene Rearrangements and Diversity

Advanced Science, EarlyView.
HTGTS‐TCR‐seq is an efficient and cost‐effective method for profiling TCRα and TCRβ rearrangements using only a few primers. It captures both productive and nonproductive recombination events, minimizes primer bias, and reveals stage‐specific and age‐related repertoire changes in mice, as well as conserved features in human peripheral T cells ...
Rui Luo, Yawei Song, Meichen Wang, Longhao Zou, Fangtai Jiao, Tiange Yang, Guangchuan Wang, Zhuoyi Liang, Wei Wu, Hai‐Qiang Dai   +9 more
wiley   +1 more source

Genetic and <i>in silico</i> functional characterization of a novel structural variant in the <i>PAH</i> gene by long-reads sequencing and structural modeling. [PDF]

Front Genet
Gallardo V, Gaete A, Maldonado J, Morales P, Peña A, Hamilton V, Faundes V, Santa María L.   +7 more
europepmc   +1 more source

Interpretation of RNA Universe and Coding Potential Using IntRNA

Advanced Science, EarlyView.
This study constructs a multi‐channel deep learning framework IntRNA to interpret RNA universe and coding potential. IntRNA consistently performed the best among existing methods in various benchmarks. Moreover, IntRNA’s interpretability is also validated by real‐world analysis, which found some features indicating long‐distance contact between ...
Yunxia Wang, Minjie Mou, Shijie Huang, Wei Zhang, Ziqi Pan, Jing Tang, Yihao Wang, Qingxia Yang, Feng Zhu   +8 more
wiley   +1 more source

Acquired MTAP Loss Following Entrectinib Resistance in ROS1-Rearranged NSCLC With CD74 Exon 3-ROS1 Exon 34 Fusion. [PDF]

Thorac Cancer
Haraguchi Hashiguchi M, Tanino M, Yoneda S, Asaoka M, Kagyo J, Katayama M, Terai H, Nakamura K, Nishihara H, Fukunaga K.   +9 more
europepmc   +1 more source

Identification of cis-acting intron and exon regions in influenza virus NS1 mRNA that inhibit splicing and cause the formation of aberrantly sedimenting presplicing complexes.

, 1992
M E Nemeroff, U Utans, A Krämer, Robert M. Krug   +3 more
openalex   +1 more source

RiboMicrobe: An Integrated Translatome Atlas for Microorganism

Advanced Science, EarlyView.
RiboMicrobe is a comprehensive database for Ribo‐seq data from prokaryotes, featuring 891 Ribo‐seq, 369 RNA‐seq, and 62 proteome datasets from 38 species. The database not only provides various data visualization results but also includes two sORF prediction models and a suit of bioinformatics tools for comparative analysis, facilitating easy access ...
Yingshun Zhou, Jinjing Luo, Xiaoqiang Lang, Yuli Gan, Guoxian Liu, Yuling Cui, Fazhi Li, Weicong Zhu, Bing Chen, Yuanyuan Dong, Yinglin Wu, Yi Cao, Qi Liu   +12 more
wiley   +1 more source

Minigene Splice Assays Allow Pathogenicity Reclassification of <i>RPE65</i> Variants of Uncertain Significance. [PDF]

Genes (Basel)
Panneman DM, Boonen EGM, Corradi Z, Cremers FPM, Roosing S.   +4 more
europepmc   +1 more source

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Bichromatic Exon-Reporters Reveal Voltage-Gated Ca²⁺-Channel Splice-Isoform Diversity across <i>Drosophila</i> Neurons In Vivo. [PDF]

eNeuro
Feghhi T, Hernandez RX, Mahneva O, Oliva CD, Macleod GT.   +4 more
europepmc   +1 more source