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Exons – Introns = Lexons: In‐frame concatenation of exons by PCR
Human Mutation, 1998A method for concatenating exons from genomic DNA, thereby skipping large stretches of intron sequence, has been developed using the polymerase chain reaction (PCR) with primers based on known intron-exon junction sequences. The use of genomic DNA circumvents the need for cDNA preparation for many purposes, including cDNA construction and mutational ...
Joanna Groden, Thérèse M. F. Tuohy
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Influence of Exon Duplication on Intron and Exon Phase Distribution
Journal of Molecular Evolution, 1998Nonrandomness in the intron and exon phase distributions in a sample of 305 human genes has been found and analyzed. It was shown that exon duplications had a significant effect on the exon phase nonrandomness. All of the nonrandomness is probably due to both the processes of exon duplication and shuffling.
Eugeni Grigor'ev +4 more
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Nature Reviews Genetics, 2019
A study in Cell identifies a mechanism by which exon splicing can increase gene expression through the activation of weak upstream promoters.
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A study in Cell identifies a mechanism by which exon splicing can increase gene expression through the activation of weak upstream promoters.
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Isolation of Exons from Cloned DNA by Exon Trapping
Current Protocols in Human Genetics, 1994AbstractExon trapping is an RNA polymerase chain reaction (PCR) method to clone expressed sequences or exons directly from mammalian genomic DNA. The basic protocol in this unit describes the method for trapping internal exons from cosmid clones and the second basic protocol describes trapping of 3 terminal exons.
Paul C. Watkins +2 more
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The universe of exons revisited [PDF]
, 2003 We study the distribution of exons in eukaryotic genes to determine whether one can detect the reuse of exon sequences and to use the frequency of such reuse to estimate how many ancestral exon sequences there might have been. We use two databases of exons.
Serge Saxonov, Walter Gilbert
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