Results 271 to 280 of about 49,802 (297)

Histone modifications influence skipped exons inclusion

Journal of Bioinformatics and Computational Biology, 2017
Alternative splicing (AS), by which individual genes can produce multiple mRNA, associates with genomic complexity, disease, and development. Histone modifications show important roles in both transcription initiation and mRNA splicing. Here, we intended to find the link between AS and histone modifications in flanking regions through analyzing ...
Hongde Liu, Wenqiao Hu, Huan Huang, Xiao Sun, Yue Hou   +4 more
openaire   +2 more sources

Overview of Alternative Oligonucleotide Chemistries for Exon Skipping

2012
The chemistry of the oligonucleotide backbone is crucial to obtaining high activity in vivo in exon skipping applications. Apart from the ability to bind strongly and sequence-specifically to pre-mRNA targets, the type of backbone also influences cell delivery, in vivo pharmacology, bio-distribution, toxicology, and ultimately the therapeutic use in ...
Amer F. Saleh, Andrey A. Arzumanov, Michael J. Gait   +2 more
openaire   +3 more sources

Exon skipping in Duchenne muscular dystrophy

Neuromuscular Disorders, 2008
What the journals ...
openaire   +2 more sources

Designing Effective Antisense Oligonucleotides for Exon Skipping

2017
During the past 10 years, antisense oligonucleotide-mediated exon skipping and splice modulation have proven to be powerful tools for correction of mRNA splicing in genetic diseases. In 2016, the US Food and Drug Administration (FDA)-approved Exondys 51 (eteplirsen) and Spinraza (nusinersen), the first exon skipping and exon inclusion drugs, to treat ...
Takenori Shimo, Takenori Shimo, Rika Maruyama, Toshifumi Yokota, Toshifumi Yokota   +4 more
openaire   +2 more sources

Exon-Skipping–Based Subtyping of Colorectal Cancers

Gastroenterology
The identification of colorectal cancer (CRC) molecular subtypes has prognostic and potentially diagnostic value for patients, yet reliable subtyping remains unavailable in the clinic. The current consensus molecular subtype (CMS) classification in CRCs is based on complex RNA expression patterns quantified at the gene level.
Aslihan Ambeskovic, Matthew N. McCall, Jonathan Woodsmith, Hartmut Juhl, Hartmut Land   +4 more
openaire   +2 more sources

EGFR and HER2 exon 20 insertions in solid tumours: from biology to treatment

Nature Reviews Clinical Oncology, 2021
Alex Friedlaender, Vivek Subbiah, Alessandro Russo   +2 more
exaly  

MET-dependent solid tumours — molecular diagnosis and targeted therapy

Nature Reviews Clinical Oncology, 2020
Robin Guo, Jia Luo, Jason C Chang
exaly  

TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A

Nature, 2022
X Rosa, Mercedes Prudencio, Yuka Koike
exaly  

Skipping breakfast is a bad idea for patients with cancer

Ca-A Cancer Journal for Clinicians, 2021
exaly  

Antitumor activity of crizotinib in lung cancers harboring a MET exon 14 alteration

Nature Medicine, 2020
Alexander Drilon, Jeffrey W Clark, Benjamin J Solomon   +2 more
exaly