Results 31 to 40 of about 127,159 (238)

Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture

Genome Biology, 2018
Background Alternative splicing, particularly through intron retention and exon skipping, is a major layer of pre-translational regulation in eukaryotes.
Xavier Grau-Bové, Iñaki Ruiz-Trillo, Manuel Irimia   +2 more
doaj   +1 more source

Exon Skipping Is Correlated with Exon Circularization

Journal of Molecular Biology, 2015
Circular RNAs are found in a wide range of organisms and it has been proposed that they perform disparate functions. However, how RNA circularization is connected to alternative splicing remains largely unexplored. Here, we stimulated primary human endothelial cells with tumor necrosis factor α or tumor growth factor β, purified RNA, generated >2.4 ...
Kelly, S, Greenman, C, Cook, PR, Papantonis, A   +3 more
openaire   +4 more sources

Exon Skipping Therapy

Cell, 2016
Exondys 51 is the first therapy for Duchenne muscular dystrophy (DMD) to have been granted accelerated approval by the FDA. Approval was granted based on using dystrophin expression as a surrogate marker. Exondys 51 targets DMD exon 51 for skipping to restore the reading frame for 13% of Duchenne patients.
Courtney S, Young, April D, Pyle
openaire   +2 more sources

Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models

Molecular Therapy: Nucleic Acids, 2019
Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models.
Florian Barthélémy, Richard T. Wang, Christopher Hsu, Emilie D. Douine, Eugene E. Marcantonio, Stanley F. Nelson, M. Carrie Miceli   +6 more
doaj   +1 more source

Mesenchymal-Epithelial Transition Exon 14 Skipping Mutation and Amplification in 5,008 Patients With Lung Cancer

Frontiers in Oncology, 2021
BackgroundLung cancer is a major health concern worldwide because of its increasing incidence and mortality. This study aimed to clarify the association between mesenchymal-epithelial transition (MET) genomic alterations and clinical characteristics of ...
Yaolin Song, Guangqi Li, Kun Ju, Wenwen Ran, Han Zhao, Xianglan Liu, Mingyu Hou, Yulu He, Yang Chen, Guoliang Zang, Xiaoming Xing   +10 more
doaj   +1 more source

CRISPR/Cas9-mediated genome editing induces exon skipping by complete or stochastic altering splicing in the migratory locust

BMC Biotechnology, 2018
Background The CRISPR/Cas9 system has been widely used to generate gene knockout/knockin models by inducing frameshift mutants in cell lines and organisms.
Dafeng Chen, Ji-Xin Tang, Beibei Li, Li Hou, Xianhui Wang, Le Kang   +5 more
doaj   +1 more source

Expert Consensus on Targeted Therapy of NSCLC with MET Exon 14 
Skipping Mutation

Chinese Journal of Lung Cancer, 2023
The mesenchymal-epithelial transition factor (MET) exon 14 skipping mutation is mainly caused by the loss of c-Cbl tyrosine binding site. This mutation could result in a decrease in the degradation rate of proteasome-mediated MET proteins, trigger ...
Lung Cancer Specialty Committee of Chinese Elderly Health Care Association
doaj   +1 more source

An Italian Multicenter Perspective Harmonization Trial for the Assessment of MET Exon 14 Skipping Mutations in Standard Reference Samples

Diagnostics, 2023
Lung cancer remains the leading cause of cancer deaths worldwide. International societies have promoted the molecular analysis of MET proto-oncogene, receptor tyrosine kinase (MET) exon 14 skipping for the clinical stratification of non-small cell lung ...
Paolo Bironzo, Francesco Pepe, Gianluca Russo, Pasquale Pisapia, Gianluca Gragnano, Gabriella Aquino, Silvia Bessi, Simonetta Buglioni, Federico Bartoccini, Giuseppina Ferrero, Michela Anna Bresciani, Paola Francia di Celle, Francesca Sibona, Andrea Giusti, Alessandra Movilia, Renata Mariella Farioli, Alessandra Santoro, Domenico Salemi, Stefania Scarpino, Dino Galafate, Stefania Tommasi, Rosanna Lacalamita, Davide Seminati, Elham Sajjadi, Silvia Novello, Fabio Pagni, Giancarlo Troncone, Umberto Malapelle   +27 more
doaj   +1 more source

Insecticide resistance mediated 1 by an exon skipping event [PDF]

, 2016
Many genes increase coding capacity by alternate exon usage. The gene encoding the insect nicotinic acetylcholine receptor (nAChR) a6 subunit, target of the bio-insecticide spinosad, is one example of this and expands protein diversity via alternative ...
Hughes, David, Bielza, P, Zimmer, Christoph T., Field, Linda M., Field, LM, Puinean, Alin Mirel, Siqueira, HA, Siqueira, Herbert A. A., Hassani-Pak, K, Bass, C., Randall, Emma, Field, L. M., Hassani-Pak, K., Hughes, D, Bielza, P., Silva, WM, Williamson, MS, Bass, Chris, Bass, C, Randall, E, Silva, Wellington M., Silva, W. M., Williamson, M. S., Bielza, Pablo, Siqueira, Herbert A.A., Puinean, Alin M., Hughes, D. J., Mellor, Ian R., Puinean, A. M., Siqueira, H. A. A., Mellor, I., Puinean, AM, Berger, M., Mellor, I, Zimmer, C. T., Randall, E., Hassani-Pak, Keywan, Berger, M, Berger, Madeleine, Williamson, Martin S., Zimmer, CT, Mellor, Ian   +41 more
core   +1 more source

Exon skipping of TGFβRI affects signalling and ECM expression in hypertrophic scar-derived fibroblasts. [PDF]

, 2020
Background In burn patients, wound healing is often accompanied by hypertrophic scar (HS) development, resulting in both functional and aesthetic problems.
Out-Luiting, Jacoba J, Raktoe, Rajiv S, van Doorn, Remco, Rietveld, Marion H, van Zuijlen, Paul Pm, Ghalbzouri, Abdoelwaheb El, Kruithof-de Julio, Marianna   +6 more
core   +2 more sources