Results 161 to 170 of about 408,908 (290)

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Harnessing CRISPR-dCas13Rx to identify novel antisense targets for therapeutic splicing modulation. [PDF]

Mol Ther Nucleic Acids
Singh RN, Alves CRR.
europepmc   +1 more source

ASCOT identifies key regulators of neuronal subtype-specific splicing [PDF]

, 2020
Blackshaw, Seth, Charles, Rone, Clark, Brian S., Ghosh, Devlina, Jiang, Lizhi, Langmead, Ben, Leavey, Patrick J., Ling, Jonathan P., Nellore, Abhinav, Pang, Bo, Santiago, Clayton P., Venkataraman, Anand, Wilks, Christopher   +12 more
core   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Three novel concomitant NTRK2 fusions in medullary thyroid carcinoma with diagnostic implications. [PDF]

Discov Oncol
Chu J, Zhao N, Yu Q, Qin L, Zhang D.
europepmc   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

CUT&Tag for High-Resolution Epigenomic Profiling From a Low Amount of <i>Arabidopsis</i> Tissue. [PDF]

Plant Direct
Fu Y, Schmid MW, Simonini S.
europepmc   +1 more source

Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean

Advanced Science, EarlyView.
This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang   +11 more
wiley   +1 more source

Reciprocal regulation of fibroblast-macrophage equilibrium governs skin integrity. [PDF]

Nat Immunol
Vollmers AC, Wu SZ, Altieri A, McCartney EE, Bender H, Davidson CD, Lee WP, Zhang J, Hu C, Jeet S, Hall B, Irizarry-Caro RA, Guarnieri A, Santosa EK, Preston J, Uttarwar S, Vander Heiden JA, Chung Y, Ortiz W, Long M, Asuncion R, Yang YA, Jiang JX, Modrusan Z, Chintalacharuvu S, Moussion C, Krishnamurty AT, Fu W, Müller S, Buechler MB, Turley SJ.   +30 more
europepmc   +1 more source

Exon [PDF]

, 2019
openaire   +3 more sources