Results 131 to 140 of about 14,025 (272)

Impact of Methods on the Measurement of mRNA Turnover [PDF]

, 2017
The turnover of the RNA molecules is determined by the rates of transcription and RNA degradation. Several methods have been developed to study RNA turnover since the beginnings of molecular biology. Here we summarize the main methods to measure RNA half-
Becskei, Attila, Wada, Takeo
core   +2 more sources

Developing a peripheral blood RNA‐seq based NETseq ensemble classifier: A potential novel tool for non‐invasive detection and treatment response assessment in neuroendocrine tumor patients receiving 177Lu‐DOTATATE PRRT

Journal of Neuroendocrinology, Volume 37, Issue 3, March 2025.
Abstract Neuroendocrine tumors (NETs) are presented with metastases due to delayed diagnosis. We aimed to identify NET‐related biomarkers from peripheral blood. The development and validation of a multi‐gene NETseq ensemble classifier using peripheral blood RNA‐Seq is reported. RNA‐Seq was performed on peripheral blood samples from 178 NET patients and
Mahesh K. Padwal, Rahul V. Parghane, Avik Chakraborty, Aman Kumar Ujaoney, Narasimha Anaganti, Sandip Basu, Bhakti Basu   +6 more
wiley   +1 more source

Arenaviridae exoribonuclease presents genomic RNA edition capacity [PDF]

, 2019
AbstractThe Arenaviridae is a large family of viruses causing both acute and persistent infections and causing significant public health concerns in afflicted regions. A “trademark” of infection is the quick and efficient immuno-suppression mediated in part by a 3’-5’ RNA exonuclease domain (ExoN) of the Nucleoprotein (NP).
E.L. Yekwa, E.L. Yekwa, E.L. Yekwa, Caroline Picard, Xavier Carnec, Sylvain Baize, François Ferron, François Ferron, Bruno Canard, Bruno Canard, Aphibanthammakit C, Aphibanthammakit C, Bruno Coutard, Bruno Coutard   +13 more
openaire   +3 more sources

Molecular mechanisms underlying the extreme mechanical anisotropy of the flaviviral exoribonuclease-resistant RNAs (xrRNAs)

Nature Communications, 2020
Mechanical anisotropy is an essential property for many biomolecules to assume their structures, functions and applications, however, the mechanisms for their direction-dependent mechanical responses remain elusive.
Xiaolin Niu, Qiuhan Liu, Zhonghe Xu, Zhifeng Chen, Linghui Xu, Lilei Xu, Jinghong Li, X. Fang   +7 more
semanticscholar   +1 more source

Rex1p Deficiency Leads to Accumulation of Precursor Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e and Polyadenylation of Substrate RNAs in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e [PDF]

, 2009
A synthetic genetic array was used to identify lethal and slow-growth phenotypes produced when a mutation in TRM6, which encodes a tRNA modification enzyme subunit, was combined with the deletion of any non-essential gene in Saccharomyces cerevisiae.
Anderson, James T., Boone, Charles, Brost, Renee L., Costanzo, Michael, Ozanick, Sarah G., Wang, Xuying   +5 more
core   +1 more source

Writing a wrong: Coupled RNA polymerase II transcription and RNA quality control [PDF]

, 2019
Processing and maturation of precursor RNA species is coupled to RNA polymerase II transcription. Co-transcriptional RNA processing helps to ensure efficient and proper capping, splicing, and 3' end processing of different RNA species to help ensure ...
Hughes, Katlyn D., Mosley, Amber L., Peck, Sarah A., Victorino, Jose F.   +3 more
core   +1 more source

Stress resilience in plants: the complex interplay between heat stress memory and resetting

New Phytologist, Volume 245, Issue 6, Page 2402-2421, March 2025.
Summary Heat stress (HS) poses a major challenge to plants and agriculture, especially during climate change‐induced heatwaves. Plants have evolved mechanisms to combat HS and remember past stress. This memory involves lasting changes in specific stress responses, enabling plants to better anticipate and react to future heat events.
Tobias Staacke, Bernd Mueller‐Roeber, Salma Balazadeh   +2 more
wiley   +1 more source

The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1

G3: Genes, Genomes, Genetics, 2018
The highly conserved DNA damage response (DDR) pathway monitors the genomic integrity of the cell and protects against genotoxic stresses. The apical kinases, Mec1 and Tel1 (ATR and ATM in human, respectively), initiate the DNA damage signaling cascade ...
Jessica P. Lao, Katie M. Ulrich, Jeffrey R. Johnson, Billy W. Newton, Ajay A. Vashisht, James A. Wohlschlegel, Nevan J. Krogan, David P. Toczyski   +7 more
doaj   +1 more source

Segmentally Variable Genes: A New Perspective on Adaptation [PDF]

, 2004
Genomic sequence variation is the hallmark of life and is key to understanding diversity and adaptation among the numerous microorganisms on earth. Analysis of the sequenced microbial genomes suggests that genes are evolving at many different rates.
Kasif, Simon, Roberts, Richard J, Zheng, Yu   +2 more
core   +4 more sources

Unleashing viral mimicry: A combinatorial strategy to enhance the efficacy of PARP7 inhibitors

BioEssays, Volume 47, Issue 2, February 2025.
This review explores the potential of inducing a viral mimicry‐primed state by combining PARP7 inhibitors with drugs that promote the accumulation of self‐nucleic acids. This synergistic approach could enhance apoptosis and the immune response against cancer cells with elevated IFN‐stimulated gene (ISG) scores, providing a promising avenue for ...
Patrick Manetsch, Michael O. Hottiger
wiley   +1 more source