3'-Phosphoadenosine 5'-Phosphate Accumulation Delays the Circadian System. [PDF]
, 2018 The circadian system optimizes cellular responses to stress, but the signaling pathways that convey the metabolic consequences of stress into this molecular timekeeping mechanism remain unclear.
Chan, Kai Xun +2 more
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Mutational analysis of exoribonuclease I from Saccharomyces cerevisiae [PDF]
, 1998 Ana M. Page +4 more
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BMC Microbiology, 2012 Background Ribonuclease R (RNase R) is an exoribonuclease that recognizes and degrades a wide range of RNA molecules. It is a stress-induced protein shown to be important for the establishment of virulence in several pathogenic bacteria. RNase R has also
Moreira Ricardo N +4 more
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A fluorescence-based assay for 3′ → 5′ exoribonucleases: Potential applications to the study of mRNA decay [PDF]
, 2000 Gerald M. Wilson +4 more
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Structured 3′ UTRs destabilize mRNAs in plants
Genome BiologyBackground RNA secondary structure (RSS) can influence the regulation of transcription, RNA processing, and protein synthesis, among other processes. 3′ untranslated regions (3′ UTRs) of mRNA also hold the key for many aspects of gene regulation. However,
Tianru Zhang +10 more
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Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis
iScience, 2021 Summary: Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity.
Shohei Takaoka +8 more
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Assessing The Role Of Multi-protein Complexes In Determining Phenotype [PDF]
, 2008 Understanding regulatory mechanisms in complex biological systems is an important challenge, in particular to understand disease mechanisms, and to discover new therapies and drugs. In this paper, we consider the important question of cellular regulation
Gentleman, Robert, Le Meur, Nolwenn
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Exoribonuclease in nonstructural protein 14 (nsp14-ExoN) [PDF]
Science-Business eXchange, 2013 In vitro studies suggest nsp14-ExoN inhibitors could help sensitize coronaviruses to RNA mutagen therapeutics including ribavirin.
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The 5′–3′ exoribonuclease xrn-1 is essential for ventral epithelial enclosure during C. elegans embryogenesis [PDF]
, 2003 Sarah F. Newbury, Alison Woollard
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TbDSS-1, an Essential Trypanosoma brucei Exoribonuclease Homolog That Has Pleiotropic Effects on Mitochondrial RNA Metabolism [PDF]
, 2004 Jonelle L. Penschow +3 more
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