Results 161 to 170 of about 14,418 (193)

The 5′–3′ exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered

Biology of the Cell, 2008
Background information. Ribonucleases have been well studied in yeast and bacteria, but their biological significance to developmental processes in multicellular organisms is not well understood.
Sarah Newbury
exaly   +2 more sources

Characterization of a bafinivirus exoribonuclease activity

Journal of General Virology, 2018
White bream virus (WBV), a poorly characterized plus-strand RNA virus infecting freshwater fish of the Cyprinidae family, is the prototype species of the genus Bafinivirus in the subfamily Torovirinae (family Coronaviridae, order Nidovirales). In common with other nidoviruses featuring >20 kilobase genomes, bafiniviruses have been predicted to encode ...
John Ziebuhr, Ramakanth Madhugiri, Nadja Karl   +2 more
exaly   +3 more sources

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Drosophila 5′ → 3′-Exoribonuclease Pacman

Methods in enzymology, 2001
Publisher Summary This chapter concentrates on the methods used to express a Drosophila recombinat 5′ → 3′-exoribonuclease, purify the protein, and analyze its activity in vitro . Analysis of early development in Drosophila has shown that RNA localization, control of translation, and mRNA stability are intimately linked.
I V, Chernukhin, J E, Seago, S F, Newbury   +2 more
  +9 more sources

Exoribonucleases and Endoribonucleases

EcoSal Plus, 2004
This review provides a description of the known Escherichia coli ribonucleases (RNases), focusing on their structures, catalytic properties, genes, physiological roles, and possible regulation. Currently, eight E. coli exoribonucleases are known.
Zhongwei, Li, Murray P, Deutscher
openaire   +2 more sources

Biochemical Characterization of Exoribonuclease Encoded by SARS Coronavirus [PDF]

BMB Reports, 2007
The nsp14 protein is an exoribonuclease that is encoded by severe acute respiratory syndrome coronavirus (SARS-CoV). We have cloned and expressed the nsp14 protein in Escherichia coli, and characterized the nature and the role(s) of the metal ions in the reaction chemistry.
Zhepeng Liu
exaly   +3 more sources

A microsomal exoribonuclease from rat liver

Biochimica Et Biophysica Acta - Biomembranes, 1979
A exoribonuclease has been purified from the microsomes of rat liver. The enzyme had an apparent molecular weight of 80 000-83 000 and produced, via a processive mechanism, 5'-AMP as the only product from poly(A). The degradation was found to proceed in the 3' to 5' direction.
Kazuei Igarashi, Seiyu Hirose
exaly   +3 more sources

Ritonavir may inhibit exoribonuclease activity of nsp14 from the SARS-CoV-2 virus and potentiate the activity of chain terminating drugs

International Journal of Biological Macromolecules, 2021
SARS-CoV-2is the causative agent for the ongoing COVID19 pandemic, and this virus belongs to the Coronaviridae family. The nsp14 protein of SARS-CoV-2 houses a 3′ to 5′ exoribonuclease activity responsible for removing mismatches that arise during genome
Naveen Narayanan, Deepak T Nair
exaly   +2 more sources

Escherichiacoli mutants deficient in exoribonucleases

Biochemical and Biophysical Research Communications, 1976
Abstract Strain S296, isolated by screening 2000 colonies after nitrosoguanidine mutagenesis, yields extracts with less than 1% of wild-type RNase activity against ( 3 H) poly(U). Unlike other E. coli strains, S296 grows with a doubling time of about 2 hr., both in nutrient broth and in minimal medium, and at 30°, 37° and 42°. The strain retains
N, Nikolaev, V, Folsom, D, Schlessinger
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Structures of 5′–3′ Exoribonucleases

2012
5'-3' Exoribonucleases (XRNs) have important functions in RNA processing, RNA turnover and decay, RNA interference, RNA polymerase transcription, and other cellular processes. Their sequences share two highly conserved regions, CR1 and CR2. The cytoplasmic Xrn1 and the nuclear Xrn2/Rat1 are found in yeast and animals, and XRNs are found in most other ...
Jeong Ho, Chang, Song, Xiang, Liang, Tong   +2 more
openaire   +2 more sources

5′-3′ Exoribonucleases

2011
The 5′-3′ exoribonucleases have important functions in RNA processing, RNA degradation, RNA interference, transcription, and other cellular processes. The Xrn1 and Xrn2/Rat1 family of enzymes are the best characterized 5′-3′ exoribonucleases, and there has been significant recent progress in the understanding of their structure and function. Especially,
Jeong Ho Chang, Song Xiang, Liang Tong
openaire   +1 more source