Results 1 to 10 of about 7,632 (199)

Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA [PDF]

Nature Communications, 2022
The cytoplasmic Xrn1 protein has long been established as the predominate 5′ to 3′ exoribonuclease that cleaves RNAs with an unprotected 5′ monophosphate end. Here the authors demonstrate Xrn1 can also degrade RNAs harboring the noncanonical nicotinamide
Sunny Sharma, Jun Yang, Ewa Grudzien-Nogalska, Jessica Shivas, Kelvin Y. Kwan, Megerditch Kiledjian   +5 more
doaj   +6 more sources

Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation [PDF]

Heliyon
The regulation of gene expression in eukaryotes relies largely on the action of exoribonucleases, evolutionarily conserved enzymes that digest decapped messenger RNAs in the 5’-3’ direction.
Satyendra Mondal, Jakub Zahumensky, Petra Vesela, Jan Malinsky   +3 more
doaj   +5 more sources

The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins [PDF]

Nature Communications, 2019
The exonuclease Xrn1 mediates crosstalk between transcription and mRNA decay in yeast. Here the authors demonstrate that Xrn1 promotes translation of mRNAs encoding membrane proteins, coupling transcription, translation, and mRNA decay.
Bernat Blasco-Moreno, Leire de Campos-Mata, René Böttcher, José García-Martínez, Jennifer Jungfleisch, Danny D. Nedialkova, Shiladitya Chattopadhyay, María-Eugenia Gas, Baldomero Oliva, José E. Pérez-Ortín, Sebastian A. Leidel, Mordechai Choder, Juana Díez   +12 more
doaj   +8 more sources

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

Cell Reports
Summary: Emerging data suggest that induction of viral mimicry responses through activation of double-stranded RNA (dsRNA) sensors in cancer cells is a promising therapeutic strategy. One approach to induce viral mimicry is to target molecular regulators
Tao Zou, Meng Zhou, Akansha Gupta, Patrick Zhuang, Alyssa R. Fishbein, Hope Y. Wei, Diego Capcha-Rodriguez, Zhouwei Zhang, Andrew D. Cherniack, Matthew Meyerson   +9 more
doaj   +7 more sources

Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer

Cell Reports
Summary: Viral mimicry describes the immune response induced by endogenous stimuli such as double-stranded RNA (dsRNA) from endogenous retroelements.
Amir Hosseini, Håvard T. Lindholm, Raymond Chen, Parinaz Mehdipour, Sajid A. Marhon, Charles A. Ishak, Paul C. Moore, Marie Classon, Andrea Di Gioacchino, Benjamin Greenbaum, Daniel D. De Carvalho   +10 more
doaj   +5 more sources

Cellular 5′-3′ mRNA Exoribonuclease XRN1 Inhibits Interferon Beta Activation and Facilitates Influenza A Virus Replication

mBio, 2021
Cellular 5′-3′ exoribonuclease 1 (XRN1) is best known for its role as a decay factor, which by degrading 5′ monophosphate RNA after the decapping of DCP2 in P-bodies (PBs) in Drosophila, yeast, and mammals.
Yen-Chin Liu, Bobo Wing-Yee Mok, Pui Wang, Rei-Lin Kuo, Honglin Chen, Shin-Ru Shih   +5 more
doaj   +3 more sources

Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis [PDF]

iScience, 2021
Summary: Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity.
Shohei Takaoka, Akiko Yanagiya, Haytham Mohamed Aly Mohamed, Rei Higa, Takaya Abe, Ken-ichi Inoue, Akinori Takahashi, Patrick Stoney, Tadashi Yamamoto   +8 more
doaj   +3 more sources

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3’,5’-bisphosphate as a potent enzyme inhibitor [PDF]

Communications Biology
XRN1 (5’-3’ exoribonuclease 1) degrades RNA from the 5′ → 3′ direction and utilizes both single- and double-stranded RNA as substrates. XRN1 plays a critical role in mRNA turnover as well as regulating the cellular response to viral infection.
Gordon J. Lockbaum, Maureen M. Lynes, Sophie A. Shen, Julie Liu, Nicholas Holt, Sunaina P. Nayak, Kevin E. Knockenhauer, Shihua Yao, E. Allen Sickmier, Anugraha Raman, Jie Wu, April Case, Livia Shehaj, Shane M. Buker, Simina Grigoriu, Scott Ribich, Stephen J. Blakemore, Brian A. Sparling, Kenneth W. Duncan, Robert A. Copeland, Serena J. Silver, P. Ann Boriack-Sjodin   +21 more
doaj   +2 more sources

Proper 5'-3' cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus. [PDF]

PLoS ONE
The budding yeast Xrn1 protein shuttles between the nucleus, where it stimulates transcription, and the cytoplasm, where it executes the major cytoplasmic mRNA decay. In the cytoplasm, apart from catalyzing 5'→3' decay onto non translated mRNAs, Xrn1 can
Antonio Jordán-Pla, Yujie Zhang, José García-Martínez, Shiladitya Chattopadhyay, Anabel Forte, Mordechai Choder, Vicent Pelechano, José E Pérez-Ortín   +7 more
doaj   +2 more sources

The zinc finger protein ZFP36L2 inhibits flavivirus infection via the 5′-3′ XRN1-mediated RNA decay pathway in the replication complexes [PDF]

Journal of Biomedical Science
Background The zinc finger protein 36-like (ZFP36L) family is a CCCH-type group consisting of RNA-binding proteins, i.e., ZFP36L1 and ZFP36L2, which regulate cellular mRNA through the RNA decay pathway. ZFP36L1 combats flavivirus infections through the 5′
Ren-Jye Lin, Li-Hsiung Lin, Zih-Ping Chen, Bing-Cheng Liu, Pin-Chen Ko, Ching-Len Liao   +5 more
doaj   +2 more sources