Investigating the correlation between Xrn1-resistant RNAs and frameshifter pseudoknots
RNA Biology, 2023 Xrn1-resistant RNA structures are multifunctional elements employed by an increasing number of RNA viruses. One of such elements is the coremin motif, discovered in plant virus RNAs, of which the structure has been hypothesized to form a yet unelucidated
Ivar W Dilweg, René C Olsthoorn
exaly +6 more sources
Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation [PDF]
HeliyonThe regulation of gene expression in eukaryotes relies largely on the action of exoribonucleases, evolutionarily conserved enzymes that digest decapped messenger RNAs in the 5’-3’ direction.
Jan Malinsky +2 more
exaly +7 more sources
Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer [PDF]
Cell ReportsSummary: Viral mimicry describes the immune response induced by endogenous stimuli such as double-stranded RNA (dsRNA) from endogenous retroelements.
Marie Classon, Amir Hosseini
exaly +6 more sources
XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells
Cell ReportsSummary: Emerging data suggest that induction of viral mimicry responses through activation of double-stranded RNA (dsRNA) sensors in cancer cells is a promising therapeutic strategy. One approach to induce viral mimicry is to target molecular regulators
Zhouwei Zhang +2 more
exaly +6 more sources
Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3’,5’-bisphosphate as a potent enzyme inhibitor [PDF]
Communications BiologyXRN1 (5’-3’ exoribonuclease 1) degrades RNA from the 5′ → 3′ direction and utilizes both single- and double-stranded RNA as substrates. XRN1 plays a critical role in mRNA turnover as well as regulating the cellular response to viral infection.
Gordon J. Lockbaum +21 more
doaj +3 more sources
MBio, 2021 Cellular 5′-3′ exoribonuclease 1 (XRN1) is best known for its role as a decay factor, which by degrading 5′ monophosphate RNA after the decapping of DCP2 in P-bodies (PBs) in Drosophila, yeast, and mammals.
Honglin Chen, Rei-Lin Kuo, Bobo Mok
exaly +3 more sources
A key role for the exoribonuclease XRN1 in regulating the hepatitis B viral transcriptome [PDF]
iScienceSummary: Chronic hepatitis B virus (HBV) is a leading cause of liver disease and hepatocellular carcinoma that persists as a DNA mini-chromosome and replicates via genomic RNA intermediates.
Senko Tsukuda +8 more
doaj +2 more sources
Comparative analysis of flavivirus sfRNA dynamics and secondary structure [PDF]
Journal of VirologyThe accumulation of subgenomic flavivirus RNAs (sfRNAs) modulates viral fitness and pathogenicity in culture and in vivo. These noncoding RNAs are produced by incomplete digestion of the flavivirus genome by the cellular 5′−3′ exoribonuclease (XRN1 ...
Camden R. Bair +4 more
doaj +2 more sources
Liquid condensates come of age: Nanoscale domains at the crossroads of stress and disease. [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Walter NG, Halder B.
europepmc +2 more sources
Hijacking innate immunity to enhance mRNA therapeutics by blocking IFN-P-body-XRN1 axis-mediated degradation [PDF]
Nature CommunicationsInnate immune activation is a major driver of unmodified in vitro–transcribed (IVT) mRNA degradation; however, how modified IVT mRNAs are degraded, and the related regulation mechanisms, remain poorly understood.
Tinghong Zhang +18 more
doaj +2 more sources