Results 31 to 40 of about 4,960 (183)
Nature Communications, 2022 Subgenomic flaviviral RNAs (sfRNAs) are produced by pathogenic flaviviruses to counteract the host antiviral response. sfRNAs are products of incomplete degradation of viral RNA by the host exoribonuclease XRN1 which stalls on XRN1-resistant structural ...
Andrii Slonchak +12 more
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, 2023 Transfection of HEp-2 cells with GFP-NLS-EDC4 (panel a) and monomeric cherry (mCh) fused to SV40 T antigen NLS and XRN1 amino acids 1232–1706 (mCh-NLS-XRN1(1232–1706) (panel b) resulted in localization of both proteins in nuclear dots (panel c) in 94+/-2%
Claire O. Sinow (14725282) +3 more
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Scientific Reports, 2023 RNAs that are able to prevent degradation by the 5’–3’ exoribonuclease Xrn1 have emerged as crucial structures during infection by an increasing number of RNA viruses.
Ivar W. Dilweg +2 more
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Functional and structural analysis of the C. elegans PAXT-1-XRN2 complex [PDF]
, 2015 XRN2 is an essential nuclear 5’ -> 3’ exoribonuclease that is involved in quality control, processing and degradation of RNAs, such as rRNA, snRNA and miRNAs. Recently, C. elegans XRN2 was discovered to exist in a stable complex with PAXT-1.
Richter, Hannes
core +1 more source
Subgenomic Flaviviral RNAs of Dengue Viruses
Viruses, 2023 Subgenomic flaviviral RNAs (sfRNAs) are produced during flavivirus infections in both arthropod and vertebrate cells. They are undegraded products originating from the viral 3′ untranslated region (3′ UTR), a result of the action of the host 5′-3 ...
Yi Liu, Wuxiang Guan, Haibin Liu
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Regulation of telomere metabolism by the RNA processing protein Xrn1 [PDF]
Nucleic Acids Research, 2017 Telomeric DNA consists of repetitive G-rich sequences that terminate with a 3΄-ended single stranded overhang (G-tail), which is important for telomere extension by telomerase. Several proteins, including the CST complex, are necessary to maintain telomere structure and length in both yeast and mammals.
Cesena, D +5 more
openaire +3 more sources
eIF2A genetically interacts with Xrn1.
, 2023 Wild-type, xrn1-deg, eif2aΔ mutant and xrn1-deg eif2aΔ double mutant were cultivated in YPGlu medium until exponential-growth phase. IAA was added at a final concentration of 100 μM and CFW was added or not at a final concentration of 500 μg/ml.
Abdelkader Namane (69431) +7 more
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Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1 [PDF]
Nature Structural & Molecular Biology, 2011 The 5'→3' exoribonucleases (XRNs) have important functions in transcription, RNA metabolism and RNA interference. The structure of Rat1 (also known as Xrn2) showed that the two highly conserved regions of XRNs form a single, large domain that defines the active site of the enzyme.
Chang, Jeong Ho +4 more
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Endogenous RNAi pathway evolutionarily shapes the destiny of the antisense lncRNAs transcriptome
Life Science Alliance, 2019 A genome-wide comparative analysis of “cryptic” aslncRNAs decay in RNAi-capable and RNAi-deficient budding yeasts suggests an evolutionary contribution of RNAi in shaping the aslncRNAs transcriptome.
Ugo Szachnowski +4 more
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Communications Biology, 2023 Most functional eukaryotic mRNAs contain a 5′ 7-methylguanosine (m7G) cap. Although capping is essential for many biological processes including mRNA processing, export and translation, the fate of uncapped transcripts has not been studied extensively ...
Onofrio Zanin +6 more
doaj +1 more source