Results 1 to 10 of about 18,176 (172)

The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease [PDF]

Biomolecules, 2015
DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3' to 5' degradation and processing of both nuclear and cytoplasmic RNA species.
Timothy J T Chevassut, Antony W. Oliver, Sarah F Newbury   +2 more
exaly   +5 more sources

Xrn1/Pacman affects apoptosis and regulates expression of hid and reaper [PDF]

Biology Open, 2015
Programmed cell death, or apoptosis, is a highly conserved cellular process that is crucial for tissue homeostasis under normal development as well as environmental stress.
Joseph A. Waldron, Christopher I. Jones, Benjamin P. Towler, Amy L. Pashler, Dominic P. Grima, Stephen Hebbes, Samuel H. Crossman, Maria V. Zabolotskaya, Sarah F. Newbury   +8 more
doaj   +4 more sources

Structural and catalytic diversity of coronavirus proofreading exoribonuclease [PDF]

Nature Communications
The coronavirus proofreading exoribonuclease (ExoN) is essential for genome fidelity and immune evasion of the viruses. Despite its critical roles in the viral life cycle, it is unclear how ExoNs across different coronaviruses diverge in their structures
Yu Li, Xiaocong Cao, Lauren M. Recker, Yang Yang, Chang Liu   +4 more
doaj   +2 more sources

Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure [PDF]

Nature Communications
Viruses from the Flaviviridae family contain human relevant pathogens that generate subgenomic noncoding RNAs during infection using structured exoribonuclease resistant RNAs (xrRNAs).
Conner J. Langeberg, Matthew J. Szucs, Madeline E. Sherlock, Quentin Vicens, Jeffrey S. Kieft   +4 more
doaj   +2 more sources

Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis [PDF]

BMC Plant Biology
Background mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of the mRNA decay process.
Marie-Christine Carpentier, Anne-Elodie Receveur, Adrien Cadoudal, Rémy Merret   +3 more
doaj   +2 more sources

The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity [PDF]

Journal of Virology
Coronaviruses (CoVs) encode non-structural proteins (nsp’s) 1–16, which assemble to form replication-transcription complexes that function in viral RNA synthesis.
Samantha L. Grimes, Brook E. Heaton, Mackenzie L. Anderson, Katie Burke, Laura Stevens, Xiaotao Lu, Nicholas S. Heaton, Mark R. Denison, Jordan Anderson-Daniels   +8 more
doaj   +2 more sources

Dis3l2 is essential for neural crest survival by modulating Akt signaling [PDF]

Cell Communication and Signaling
DIS3-like 3’-5’ exoribonuclease 2 (DIS3L2), an exoribonuclease, is known to preferentially degrade uridylated RNA substrates, miRNAs, and ncRNAs. Recent reports show that DIS3L2 also plays a key role in cell proliferation and tumor growth.
Sian D’Silva, Tuhina Prasad, Megha Kumar   +2 more
doaj   +2 more sources

Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations

MBio, 2017
The coronavirus (CoV) RNA genome is the largest among the single-stranded positive-sense RNA viruses. CoVs encode a proofreading 3′-to-5′ exoribonuclease within nonstructural protein 14 (nsp14-ExoN) that is responsible for CoV high-fidelity replication ...
Xiaotao Lu, Mark R Denison
exaly   +3 more sources

Beet Necrotic Yellow Vein Virus Noncoding RNA Production Depends on a 5′→3′ Xrn Exoribonuclease Activity

Viruses, 2018
The RNA3 species of the beet necrotic yellow vein virus (BNYVV), a multipartite positive-stranded RNA phytovirus, contains the ‘core’ nucleotide sequence required for its systemic movement in Beta macrocarpa.
Claudio Ratti, Jeffrey Wilusz, David Gilmer   +2 more
exaly   +3 more sources

RPA transforms RNase H1 to a bidirectional exoribonuclease for processive RNA–DNA hybrid cleavage [PDF]

Nature Communications
RNase H1 has been acknowledged as an endoribonuclease specializing in the internal degradation of the RNA moiety within RNA–DNA hybrids, and its ribonuclease activity is indispensable in multifaceted aspects of nucleic acid metabolism.
Yanan Li, Chao Liu, Xinshuo Jia, Lulu Bi, Zhiyun Ren, Yilin Zhao, Xia Zhang, Lijuan Guo, Yanling Bao, Cong Liu, Wei Li, Bo Sun   +11 more
doaj   +2 more sources