Results 1 to 10 of about 14,418 (193)
Structural and catalytic diversity of coronavirus proofreading exoribonuclease [PDF]
Nature CommunicationsThe coronavirus proofreading exoribonuclease (ExoN) is essential for genome fidelity and immune evasion of the viruses. Despite its critical roles in the viral life cycle, it is unclear how ExoNs across different coronaviruses diverge in their structures
Yu Li +4 more
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Novel Mechanisms of SARS-CoV-2 Drug Resistance and Rational Design of Anti-Resistant Antivirals [PDF]
MoleculesAntiviral drug resistance in SARS-CoV-2 is increasingly limiting treatment efficacy. Four recent studies have revealed two key resistance mechanisms: (1) Mutations in the main protease (Mpro)—including E166V, E166A, and S144-series variants—disrupt drug ...
Xianghan Bai +4 more
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Regulation of RNase PH during nutrient deprivation: the role of proteases, GroEL, and RNase II [PDF]
mBioRNase PH is a critical exoribonuclease in Escherichia coli that participates in tRNA maturation and RNA degradation. In earlier work, it was observed that levels of RNase PH decreased as much as 90% under conditions of nutrient deprivation, such as ...
Ashraf Hussain, Murray P. Deutscher
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Biomolecules, 2015 DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3' to 5' degradation and processing of both nuclear and cytoplasmic RNA species.
Timothy Chevassut +2 more
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Viruses, 2018 The RNA3 species of the beet necrotic yellow vein virus (BNYVV), a multipartite positive-stranded RNA phytovirus, contains the ‘core’ nucleotide sequence required for its systemic movement in Beta macrocarpa.
Jeffrey Wilusz +2 more
exaly +3 more sources
Frontiers in Microbiology, 2019 Among RNA viruses, the order Nidovirales stands out for including viruses with the largest RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing machinery comprising a variety of non-structural proteins (nsps).
Natacha Ogando +2 more
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Distinct modes of RNA degradation by the structurally related coronavirus and arenavirus exoribonucleases [PDF]
Journal of VirologyCoronaviruses and arenaviruses encode evolutionarily related DEDDh-family 3′–5′ exoribonuclease (ExoN) domains, which support the replication of their RNA genomes and evasion of the host’s antiviral immunity.
Patricia C. Hernandez +2 more
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A glycolytic intermediate gatekeeps global mRNA decay in Escherichia coli [PDF]
Nature CommunicationsPolynucleotide phosphorylase (PNPase) is a highly conserved exoribonuclease crucial for RNA degradation across all domains of life. In bacteria, PNPase is found in multi-protein ribonucleolytic complexes that include glycolytic enzymes.
Ander Hernández Plágaro +9 more
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The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity [PDF]
Journal of VirologyCoronaviruses (CoVs) encode non-structural proteins (nsp’s) 1–16, which assemble to form replication-transcription complexes that function in viral RNA synthesis.
Samantha L. Grimes +8 more
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Regulation of co-translational mRNA decay by PAP and DXO1 in Arabidopsis [PDF]
BMC Plant BiologyBackground mRNA decay is central in the regulation of mRNA homeostasis in the cell. The recent discovery of a co-translational mRNA decay pathway (also called CTRD) has changed our understanding of the mRNA decay process.
Marie-Christine Carpentier +3 more
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