Regulation of miRNA content. Part 2. Degradation of miRNAs
Zdorovʹe Rebenka, 2021 The scientific review presents the process of regulation of microRNA content — microRNA degradation. To write the article, information was searched using databases Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The ...
A.E. Abaturov, V.L. Babуch
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Exoribonuclease RNase R protects Antarctic Pseudomonas syringae Lz4W from DNA damage and oxidative stress. [PDF]
, 2023 Bacterial exoribonucleases play a crucial role in RNA maturation, degradation, quality control, and turnover. In this study, we have uncovered a previously unknown role of 3-5 exoribonuclease RNase R of Pseudomonas syringae Lz4W in DNA damage and ...
Mittal, Pragya +7 more
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Crystallographic Studies of Bacterial Exoribonucleases [PDF]
The Scientific World JOURNAL, 2002 INTRODUCTION. Ribonucleases (RNases) play a central role in all cellular RNA processes. These processes include mRNA degradation, and maturation and turnover of stable RNAs, which are vital for the proper functioning of all cells. E. coli has served as a model system for understanding the role of ribonucleases in RNA metabolism, and eight distinct ...
Tristan J. Fiedler, Arun Malhotra
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Ritonavir May Inhibit Exoribonuclease Activity of Nsp14 from the SARS-CoV-2 Virus and Potentiate the Activity of Chain Terminating Drugs [PDF]
, 2020 SARS-CoV-2 is the causative agent for the ongoing COVID19 pandemic, and this virus belongs to the Coronaviridae family. The nsp14 protein of SARS-CoV-2 houses a 3’ to 5’ exoribonuclease activity responsible for removing mismatches that arise during ...
deepak t, nair, naveen, narayanan
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The Absence of E. coli Nucleoid-Associated Protein FIS at Low Temperature Leads to an Adaptation Response That Causes a Shift Towards Genome Compaction in Small Rods. [PDF]
Mol MicrobiolUnlike the wild‐type BW25113, the fis null mutant is characterized by biphasic growth at 12°C. During the first phase of growth, the absence of FIS results in the formation of filaments with dispersed nucleoids. During the acclimation phase, the FIS Null Adaptation Response is activated that leads to an increase in cell division and nucleoid ...
Jones PG.
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Real-time fluorescence detection of exoribonucleases [PDF]
RNA, 2009 The identification of RNases or RNase effectors is a continuous challenge, particularly given the current importance of RNAs in the control of genome expression. Here, we show that a fluorogenic RNA–DNA hybrid is a powerful tool for a real-time fluorescence detection and assay of exoribonucleases (RT-FeDEx).
Sinturel, F. +5 more
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CATALYTIC PROPERTIES OF THE EUKARYOTIC EXOSOME [PDF]
, 2010 The eukaryotic exosome complex is built around the backbone of a 9‑subunit ring similar to phosporolytic ribonucleases such as RNase PH and polynucleotide phosphorylase (PNPase).
María Eugenia Gas López +13 more
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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease. [PDF]
, 2021 SARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world causing a deadly pandemic with tremendous social and economic costs.
Agustina P Bertolin (11103225) +18 more
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Exoribonucleases as Modulators of Virulence in Pathogenic Bacteria [PDF]
Frontiers in Cellular and Infection Microbiology, 2012 Pathogenic bacteria are responsible for severe diseases worldwide. RNA stability is a major player controlling the expression of virulence factors. Ribonucleases (RNases) are the enzymes responsible for the maturation and degradation of RNA molecules (Arraiano et al., 2010; Silva et al., 2011).
Matos, Rute G. +4 more
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Molecular and developmental analysis of non-coding RNA metabolism in" C. elegans" : the exoribonuclease XRN2 and the RNA- binding proteins SART-3 and USIP-1 [PDF]
, 2014 About three quarters of a eukaryotic genome are transcribed into RNA. However, only
Rüegger, Stefan
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