Results 41 to 50 of about 14,418 (193)
mBio, 2017 The coronavirus (CoV) RNA genome is the largest among the single-stranded positive-sense RNA viruses. CoVs encode a proofreading 3′-to-5′ exoribonuclease within nonstructural protein 14 (nsp14-ExoN) that is responsible for CoV high-fidelity replication ...
Kevin W. Graepel +5 more
doaj +1 more source
The coronavirus proofreading exoribonuclease mediates extensive viral recombination.
PLoS Pathogens, 2021 Recombination is proposed to be critical for coronavirus (CoV) diversity and emergence of SARS-CoV-2 and other zoonotic CoVs. While RNA recombination is required during normal CoV replication, the mechanisms and determinants of CoV recombination are not ...
Jennifer Gribble +8 more
doaj +1 more source
RRP6 from Trypanosoma brucei: crystal structure of the catalytic domain, association with EAP3 and activity towards structured and non-structured RNA substrates. [PDF]
PLoS ONE, 2014 RRP6 is a 3'-5' exoribonuclease associated to the eukaryotic exosome, a multiprotein complex essential for various RNA processing and degradation pathways.
Rosicler L Barbosa +5 more
doaj +1 more source
Ribonuclease T: new exoribonuclease possibly involved in end-turnover of tRNA [PDF]
, 1984 Examination of double mutants lacking one of the exoribonucleases, RNase II, RNase D, RNase BN, or RNase R, and also devoid of tRNA nucleotidyltransferase has suggested that none of these RNases participates in the end-turnover of tRNA.
Marlor, C W +2 more
core +6 more sources
Degradation of microRNAs by a Family of Exoribonucleases in Arabidopsis [PDF]
Science, 2008 microRNAs (miRNAs) play crucial roles in numerous developmental and metabolic processes in plants and animals. The steady-state levels of miRNAs need to be properly controlled to ensure normal development. Whereas the framework of miRNA biogenesis is established, factors involved in miRNA degradation remain unknown.
Vanitharani, Ramachandran, Xuemei, Chen
openaire +2 more sources
, 2023 Summary In plants, exoribonuclease‐resistant RNAs (xrRNAs) are produced by many viruses. Whereas xrRNAs contribute to the pathogenicity of these viruses, the role of xrRNAs in the virus infectious cycle remains elusive. Here, we show that xrRNAs produced
Savenkov, Eugene I. +7 more
core +2 more sources
Suppression of Viral RNA Recombination by a Host Exoribonuclease [PDF]
Journal of Virology, 2006 ABSTRACT RNA viruses of humans, animals, and plants evolve rapidly due to mutations and RNA recombination. A previous genome-wide screen in Saccharomyces cerevisiae , a model host, identified five host genes, including XRN1 , encoding a 5′-3′ exoribonuclease, whose absence led to an
Chi-Ping, Cheng +2 more
openaire +2 more sources
Nature Communications, 2020 Bacterial RNA degradation is typically initiated by endoribonucleases and followed by exoribonucleases. Here the authors report the targetome of endoRNase Y in Streptococcus pyogenes, revealing the interplay between RNase Y and 3′-to-5′ exoribonuclease ...
Laura Broglia +6 more
doaj +1 more source
A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe. [PDF]
PLoS Genetics, 2016 Epigenetic gene silencing plays a critical role in regulating gene expression and contributes to organismal development and cell fate acquisition in eukaryotes.
James Franklin Tucker +6 more
doaj +1 more source
Nature Communications, 2022 Subgenomic flaviviral RNAs (sfRNAs) are produced by pathogenic flaviviruses to counteract the host antiviral response. sfRNAs are products of incomplete degradation of viral RNA by the host exoribonuclease XRN1 which stalls on XRN1-resistant structural ...
Andrii Slonchak +12 more
doaj +1 more source