Results 31 to 40 of about 14,418 (193)
Nature Communications, 2021 Exoribonuclease-resistant RNAs (xrRNAs) are RNA elements that block the exoribonucleolytic degradation of RNA. Here the authors show how a long-range pseudoknot length modulates the Mg2+-dependence of flaviviral xrRNA’s folding, conformational dynamics ...
Xiaolin Niu +6 more
doaj +1 more source
Immunosuppressive arenaviral exoribonuclease
Oncotarget, 2015 Arenaviruses cause up to 500,000 zoonotic infections per year in endemic areas of Africa and South America and can lead to severe and lethal hemorrhagic fever (HF) symptoms [1]. Currently, there is no specific antiviral drug or vaccine available for the treatment of these infections, with the exception of the Candid #1 vaccine that has successfully ...
Bjoern, Meyer, Hinh, Ly
openaire +2 more sources
Functional and structural analysis of the C. elegans PAXT-1-XRN2 complex [PDF]
, 2015 XRN2 is an essential nuclear 5’ -> 3’ exoribonuclease that is involved in quality control, processing and degradation of RNAs, such as rRNA, snRNA and miRNAs. Recently, C. elegans XRN2 was discovered to exist in a stable complex with PAXT-1.
Richter, Hannes
core +1 more source
RNA decay and RNA silencing in plants: competition or collaboration?
Frontiers in Plant Science, 2011 Initiation of RNA polymerase II transcription signals the beginning of a series of physically and functionally coupled pre-mRNA processing events that transform an RNA transcript into a highly structured, mature ribonucleoprotein complex.
Michael eChristie +3 more
doaj +1 more source
Tombusvirids Avoid and Exploit a Plant Exoribonuclease [PDF]
, 2022 Tombusviridae is a family of plus-strand RNA plant viruses that contain single-stranded RNA genomes with no 5' cap or 3' poly(A) tail. The 5' cap is an essential post-transcriptional modification that increases the stability of mRNA molecules, by ...
Gunawardene, Chaminda Dinuka
core
The roles of the exoribonucleases DIS3L2 and XRN1 in human disease [PDF]
Biochemical Society Transactions, 2016 RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 have been well studied, less is ...
Pashler, Amy L +3 more
openaire +2 more sources
Scientific Reports, 2021 Tick-borne flaviviruses (TBFVs) infect mammalian hosts through tick bites and can cause various serious illnesses, such as encephalitis and hemorrhagic fevers, both in humans and animals.
Hayato Harima +19 more
doaj +1 more source
Selective 2′-Hydroxyl Acylation Analyzed by Protection from Exoribonuclease [PDF]
, 2010 Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) is a powerful approach for characterizing RNA structure and dynamics at single-nucleotide resolution.
Weeks, Kevin M. +6 more
core +1 more source
eLife, 2017 RNA-induced silencing complex (RISC) is composed of miRNAs and AGO proteins. AGOs use miRNAs as guides to slice target mRNAs to produce truncated 5' and 3' RNA fragments. The 5' cleaved RNA fragments are marked with uridylation for degradation.
Zhonghui Zhang +9 more
doaj +1 more source
Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA
Nature Communications, 2022 The cytoplasmic Xrn1 protein has long been established as the predominate 5′ to 3′ exoribonuclease that cleaves RNAs with an unprotected 5′ monophosphate end. Here the authors demonstrate Xrn1 can also degrade RNAs harboring the noncanonical nicotinamide
Sunny Sharma +5 more
doaj +1 more source