Results 61 to 70 of about 18,176 (172)
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.Proteomic profiling of tissue explant‐ and plasma‐derived extracellular vesicles identified colon adenocarcinoma‐associated and healthy‐associated EV proteins. A 10‐protein EV panel enabled highly sensitive blood‐based detection of colon adenocarcinoma, showed marked postoperative changes, and retained performance in an independent validation cohort ...
Yura Seo +33 more
wiley +1 more source
Impact of Methods on the Measurement of mRNA Turnover [PDF]
, 2017 The turnover of the RNA molecules is determined by the rates of transcription and RNA degradation. Several methods have been developed to study RNA turnover since the beginnings of molecular biology. Here we summarize the main methods to measure RNA half-
Becskei, Attila, Wada, Takeo
core +2 more sources
Microbial Biotechnology, Volume 19, Issue 4, April 2026.The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley +1 more source
The Plant Journal, Volume 126, Issue 1, April 2026.SUMMARY Viral diseases pose a significant threat to global apple (Malus spp.) production. While selecting appropriate rootstocks is a crucial strategy to mitigate their effects, the underlying mechanisms governing rootstock tolerance or sensitivity to viral infection at the root level remain underexplored.
Larissa Carvalho Costa +8 more
wiley +1 more source
Regulation of tomato fruit ripening [PDF]
, 2009 Fruit ripening is a sophisticatedly orchestrated developmental process, unique to plants, that results in major physiological and metabolic changes, ultimately leading to fruit decay and seed dispersal.
Bouzayen, Mondher +4 more
core +2 more sources
Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity
Advanced Science, Volume 13, Issue 16, 18 March 2026.Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu +5 more
wiley +1 more source
Ecology and Evolution, Volume 16, Issue 3, March 2026.ABSTRACT Global environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the molecular level, less is known about the proteome, which reflects post ...
João M. Moreno +5 more
wiley +1 more source
The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes. [PDF]
PLoS Pathogens, 2017 5'-3' decay is the major mRNA decay pathway in many eukaryotes, including trypanosomes. After deadenylation, mRNAs are decapped by the nudix hydrolase DCP2 of the decapping complex and finally degraded by the 5'-3' exoribonuclease. Uniquely, trypanosomes
Susanne Kramer
doaj +1 more source
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis
iScience, 2021 Summary: Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity.
Shohei Takaoka +8 more
doaj +1 more source
Rex1p Deficiency Leads to Accumulation of Precursor Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e and Polyadenylation of Substrate RNAs in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e [PDF]
, 2009 A synthetic genetic array was used to identify lethal and slow-growth phenotypes produced when a mutation in TRM6, which encodes a tRNA modification enzyme subunit, was combined with the deletion of any non-essential gene in Saccharomyces cerevisiae.
Anderson, James T. +5 more
core +1 more source