Results 81 to 90 of about 14,418 (193)
Glia, Volume 74, Issue 5, May 2026.ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei +13 more
wiley +1 more source
The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma [PDF]
Arthritis Research & Therapy, 2000 The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major autoantigens that are recognized by anti-PM/Scl autoantibodies are designated PM/Scl-100 and PM/Scl-75.
Brouwer, R. +2 more
openaire +3 more sources
Microbial Biotechnology, Volume 19, Issue 5, May 2026.Chemical structure of RIBOTAC inhibitor with metabolic handle binding as nucleotide analogue to SARS‐CoV‐2 RNA dependent RNA polymerase, its linker and the RNase L recruiter which binds RNase L monomers and mediates their dimerization that actives nuclease activity degrading the viral RNA.
Harald Brüssow
wiley +1 more source
Exoribonuclease superfamilies: structural analysis and phylogenetic distribution
Nucleic Acids Research, 2001 Exoribonucleases play an important role in all aspects of RNA metabolism. Biochemical and genetic analyses in recent years have identified many new RNases and it is now clear that a single cell can contain multiple enzymes of this class. Here, we analyze the structure and phylogenetic distribution of the known exoribonucleases.
Y, Zuo, M P, Deutscher
openaire +3 more sources
ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in Ribosome biogenesis.
, 2008 International audienceProteomic analyses of human nucleoli provided molecular bases for an understanding of the multiple functions fulfilled by these nuclear domains. However, the biological roles of about 100 of the identified proteins are unpredictable.
Duret, Laurent +8 more
core +1 more source
Viruses, 2020 The Zika virus (ZIKV), like other flaviviruses, produces several species of sub-genomic RNAs (sfRNAs) during infection, corresponding to noncoding RNA fragments of different lengths that result from the exonuclease degradation of the viral 3 ...
Hadrian Sparks +4 more
doaj +1 more source
The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes. [PDF]
PLoS Pathogens, 2017 5'-3' decay is the major mRNA decay pathway in many eukaryotes, including trypanosomes. After deadenylation, mRNAs are decapped by the nudix hydrolase DCP2 of the decapping complex and finally degraded by the 5'-3' exoribonuclease. Uniquely, trypanosomes
Susanne Kramer
doaj +1 more source
Novel roles of sulfur metabolism in stress‐controlled stomata aperture regulation
New Phytologist, Volume 250, Issue 3, Page 1460-1467, May 2026.Summary Stomatal closure allows plants to conserve water by reducing transpiration during drought. Surprisingly, the assimilation of the macronutrient sulfur is intimately connected to the drought stress response. This Tansley insight will only briefly touch on the general impact of sulfate assimilation on the production of drought‐response metabolites.
Sheng‐Kai Sun +2 more
wiley +1 more source
The roles of 3′-exoribonucleases and the exosome in trypanosome mRNA degradation [PDF]
RNA, 2013 The degradation of eukaryotic mRNAs can be initiated by deadenylation, decapping, or endonuclease cleavage. This is followed by 5′–3′ degradation by homologs of Xrn1, and/or 3′–5′ degradation by the exosome. We previously reported that, in African trypanosome Trypanosoma brucei, most mRNAs are deadenylated prior to degradation, and that depletion of ...
Fadda, Abeer +3 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 19, 2 April 2026.We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang +10 more
wiley +1 more source