Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 [PDF]
, 2011 The 5'-cap-structures of higher eukaryote mRNAs are ribose 2'-O-methylated. Likewise, a number of viruses replicating in the cytoplasm of eukayotes have evolved 2'-O-methyltransferases to modify autonomously their mRNAs.
A Ghosh +55 more
core +1 more source
Nuclear Surveillance and Degradation of Hypomodified Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e in \u3cem\u3eS. cerevisiae\u3c/em\u3e [PDF]
, 2004 The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m1A methyltransferase (Mtase) and a temperature-sensitive growth phenotype
Anderson, James T. +5 more
core +1 more source
KSHV SOX mediated host shutoff: the molecular mechanism underlying mRNA transcript processing [PDF]
, 2017 Onset of the lytic phase in the KSHV life cycle is accompanied by the rapid, global degradation of host (and viral) mRNA transcripts in a process termed host shutoff. Key to this destruction is the virally encoded alkaline exonuclease SOX.
Bagnéris, C +7 more
core +1 more source
Frontiers in GeneticsThe control of gene expression is a fundamental process essential for correct development and to maintain homeostasis. Many post-transcriptional mechanisms exist to maintain the correct levels of each RNA transcript within the cell.
Elisa I. M. Bernard +4 more
doaj +1 more source
Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs [PDF]
, 2016 The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. Here, we used extensive global transcriptomic and targeted biochemical analyses to identify novel DIS3L2 substrates in human cells.
Bijata, Krystian +6 more
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Characterization of Isolated Bioactive Phytoconstituents from Flacourtia Indica as Potential Phytopharmaceuticals-An in Silico Perspective [PDF]
, 2016 The dependence of mankind for therapeutic applications on plants dates back to the start of the human race. Natural remedies from ethnobotanicals are found to be safe and cost effective.
Arbaaz Ahmed, L. +3 more
core
, 2017 Ethylene is a volatile 2-carbon atom molecule with hormonal properties in plants. In cross-talk with other hormones, it plays a pivotal role in controlling plant growth, through regulation of cell expansion.
Depaepe, Thomas +1 more
core +1 more source
Mitochondrial genetics of alloplasmic male-sterile Brassica napus lines [PDF]
, 2005 Reliable and economical production of hybrid (F1) varieties requires efficient means to control pollination. The predominant system for pollination control of most field crops today is cytoplasmic male sterility (CMS).
Leino, Matti
core
Structured 3′ UTRs destabilize mRNAs in plants
Genome BiologyBackground RNA secondary structure (RSS) can influence the regulation of transcription, RNA processing, and protein synthesis, among other processes. 3′ untranslated regions (3′ UTRs) of mRNA also hold the key for many aspects of gene regulation. However,
Tianru Zhang +10 more
doaj +1 more source
ePRINT: exonuclease assisted mapping of protein-RNA interactions
Genome BiologyRNA-binding proteins (RBPs) regulate key aspects of RNA processing including alternative splicing, mRNA degradation and localization by physically binding RNA molecules.
Sophie Hawkins +6 more
doaj +1 more source