Results 101 to 110 of about 14,418 (193)

TbMP42, a protein component of the RNA editing complex in African trypanosomes, has endo-exoribonuclease activity.

, 2005
RNA editing in trypanosomatids is catalyzed by a high molecular mass RNP complex, which is only partially characterized. TbMP42 is a 42 kDa protein of unknown function that copurifies with the editing complex.
Schlüter, Elke, Niemann, Moritz, Göringer, H. Ulrich, Brecht, Michael, Stuart, Ken, Müller, Ulrich F.   +5 more
core  

Purification of a human polyribosome-associated 3‘ to 5‘ exoribonuclease.

Journal of Biological Chemistry, 1994
In cells and cell-free extracts, the early steps in histone mRNA decay occur at the 3' terminus and appear to be catalyzed by a polysome-associated 3' to 5' exoribonuclease. We describe the purification of a polysomal 3' to 5' exoribonuclease that is magnesium-dependent, active at pH 7-8 in salt concentrations below 200 mM, and resistant to the ...
N, Caruccio, J, Ross
openaire   +2 more sources

Novel mRNA-silencing bodies at the synapse: A never-ending story

Communicative & Integrative Biology, 2016
Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs.
María Gabriela Thomas, Graciela Lidia Boccaccio   +1 more
doaj   +1 more source

The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1

G3: Genes, Genomes, Genetics, 2018
The highly conserved DNA damage response (DDR) pathway monitors the genomic integrity of the cell and protects against genotoxic stresses. The apical kinases, Mec1 and Tel1 (ATR and ATM in human, respectively), initiate the DNA damage signaling cascade ...
Jessica P. Lao, Katie M. Ulrich, Jeffrey R. Johnson, Billy W. Newton, Ajay A. Vashisht, James A. Wohlschlegel, Nevan J. Krogan, David P. Toczyski   +7 more
doaj   +1 more source

Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3′ → 5′ exoribonuclease

, 2017
Ribonucleases catalyze maturation of functional RNAs or mediate degradation of cellular transcripts, activities that are critical for gene expression control.
Sara Silva, Pillai, Ramesh, Silva, Sara, Homolka, David, David Homolka, Ramesh S. Pillai   +5 more
core   +1 more source

A Two-Headed Monster to Avert Disaster: HBS1/SKI7 Is Alternatively Spliced to Build Eukaryotic RNA Surveillance Complexes

Frontiers in Plant Science, 2018
The cytosolic RNA exosome, a 3′→5′ exoribonuclease complex, contributes to mRNA degradation in eukaryotes, limiting the accumulation of poorly-translated, improperly translated, or aberrant mRNA species.
Jacob O. Brunkard, Jacob O. Brunkard, Barbara Baker, Barbara Baker   +3 more
doaj   +1 more source

The pseudoknot structure of a viral RNA reveals a conserved mechanism for programmed exoribonuclease resistance

Exoribonuclease-resistant RNAs (xrRNAs) are viral RNA structures that block degradation by cellular 5'-3' exoribonucleases to produce subgenomic viral RNAs during infection.
Cronin, Matt, Yang, Feiyue, Kuo, Yen-Wen, McDonald, Jayden T, Korn, Sophie M, Erickson, Anna, Wimberly, Brian T, Gezelle, Jeanine G, Steckelberg, Anna-Lena, Gong, Zhen, Huang, Chih-Hung   +10 more
core   +1 more source

Characterisation of the in-vivo miRNA landscape in Drosophila ribonuclease mutants reveals Pacman-mediated regulation of the highly conserved let-7 cluster during apoptotic processes

Frontiers in Genetics
The control of gene expression is a fundamental process essential for correct development and to maintain homeostasis. Many post-transcriptional mechanisms exist to maintain the correct levels of each RNA transcript within the cell.
Elisa I. M. Bernard, Benjamin P. Towler, Benjamin P. Towler, Oliver M. Rogoyski, Sarah F. Newbury   +4 more
doaj   +1 more source

Biochemical characterization of campylobacter jejuni pnpase, an exoribonuclease important for bacterial pathogenicity

, 2018
International audienceBacteria need to promptly respond to environmental changes. Ribonucleases (RNases) are key factors in the adaptation to new environments by enabling a rapid adjustment in RNA levels. The exoribonuclease polynucleotide phosphorylase (
Cecília M. Arraiano, Jorge Casinhas, Casinhas, Jorge, Haddad, Nabila, Arraiano, Cecília M., Matos, Rute G., Rute G. Matos, Nabila Haddad   +7 more
core   +1 more source

Conserved mechanism of Xrn1 regulation by glycolytic flux and protein aggregation

Heliyon
The regulation of gene expression in eukaryotes relies largely on the action of exoribonucleases, evolutionarily conserved enzymes that digest decapped messenger RNAs in the 5’-3’ direction.
Satyendra Mondal, Jakub Zahumensky, Petra Vesela, Jan Malinsky   +3 more
doaj   +1 more source