Results 91 to 100 of about 18,176 (172)

Regulation of cytoplasmic RNA stability: lessons from drosophila [PDF]

, 2018
The process of RNA degradation is a critical level of regulation contributing to the control of gene expression. In the last two decades a number of studies have shown the specific and targeted nature of RNA decay and its importance in maintaining ...
Abdelmohsen, Allmang, Ameres, An, Antic, Astuti, Baccarini, Bakheet, Bakheet, Bakheet, Bassett, Bazzini, Berezikov, Bitetti, Boczonadi, Bonneau, Bortolamiol-Becet, Braun, Brown, Burroughs, Cairrao, Cairrao, Callahan, Carballo, Chang, Chang, Chapman, Chapman, Cheadle, Chen, De Almeida, De Lella Ezcurra, Decker, Di Donato, Ding, Duffy, Eberle, Eckmann, Eggens, Eulalio, Faehnle, Fenger-Gron, Forstemann, Frazao, Garneau, Gatfield, Graham, Graham, Grima, Groen, Gudipati, Haas, Hales, Han, Han, Heo, Hopkins, Hou, Iwasaki, Jonas, Jones, Jones, Jones, Juvvuna, Kaberdin, Kadaba, Kahvejian, Katoh, Kim, Kim, Kinoshita, Kiss, Kowalinski, Larimer, Lebreton, Lee, Li, Lim, Lin, Liu, Londin, Lowell, Lubas, Makino, Malecki, Malet, Mamolen, Marin-Vicente, Maryati, Mata, Mitchell, Modepalli, Molleston, Moon, Morris, Mullen, Murakami, Murray, Nagarajan, Newbury, Ng, Nishioka, Ohkura, Okada, Orban, Pandey, Park, Pashler, Peng, Perez-Ortin, Pfeiffer, Pirouz, Preker, Presnyak, Rehwinkel, Reimao-Pinto, Reimao-Pinto, Reis, Reiter, Rissland, Rose, Russo, Schaeffer, Schaeffer, Schaeffer, Schertel, Schneider, Schneider, Schneider, Schoenberg, Sharif, Sinturel, Smith, Snee, Spasic, Staals, Steinbrunn, Suh, Synowsky, Temme, Temme, Tharun, Thomas, Till, Tomari, Tomecki, Tomecki, Towler, Towler, Towler, Ustianenko, Vallejo, Vindry, Wahle, Waldron, Wan, Wasmuth, Wei, Wells, Wolf, Wyers, Wyman, Yamashita, Zabolotskaya, Zhang   +164 more
core   +1 more source

Novel mRNA-silencing bodies at the synapse: A never-ending story

Communicative & Integrative Biology, 2016
Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs.
María Gabriela Thomas, Graciela Lidia Boccaccio   +1 more
doaj   +1 more source

A Two-Headed Monster to Avert Disaster: HBS1/SKI7 Is Alternatively Spliced to Build Eukaryotic RNA Surveillance Complexes

Frontiers in Plant Science, 2018
The cytosolic RNA exosome, a 3′→5′ exoribonuclease complex, contributes to mRNA degradation in eukaryotes, limiting the accumulation of poorly-translated, improperly translated, or aberrant mRNA species.
Jacob O. Brunkard, Jacob O. Brunkard, Barbara Baker, Barbara Baker   +3 more
doaj   +1 more source

Overexpression of a natural chloroplast-encoded antisense RNA in tobacco destabilizes 5S rRNA and retards plant growth [PDF]

, 2010
Background The roles of non-coding RNAs in regulating gene expression have been extensively studied in both prokaryotes and eukaryotes, however few reports exist as to their roles in organellar gene regulation.
Amber M Hotto, Zoe E Huston, David B Stern   +2 more
core   +1 more source

The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1

G3: Genes, Genomes, Genetics, 2018
The highly conserved DNA damage response (DDR) pathway monitors the genomic integrity of the cell and protects against genotoxic stresses. The apical kinases, Mec1 and Tel1 (ATR and ATM in human, respectively), initiate the DNA damage signaling cascade ...
Jessica P. Lao, Katie M. Ulrich, Jeffrey R. Johnson, Billy W. Newton, Ajay A. Vashisht, James A. Wohlschlegel, Nevan J. Krogan, David P. Toczyski   +7 more
doaj   +1 more source

Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5′-3′ exoribonuclease) in the nucleoplasm [PDF]

, 2015
Collaborator of alternative reading frame protein (CARF) associates directly with ARF, p53, and/or human double minute 2 protein (HDM2), a ubiquitin-protein ligase, without cofactors and regulates cell proliferation by forming a negative feedback loop ...
Bertwistle, Harunori Yoshikawa, Hasan, Hideaki Ishikawa, Keiichi Izumikawa, Nobuhiro Takahashi, Richard J. Simpson, Sauer, Shigeko Sato, Sugimoto, Yanagida, Yi, Zhang, Zhang   +13 more
core   +2 more sources

Xrn1 Exoribonuclease—An Intrinsic Marker of Yeast Population Growth

Frontiers in Bioscience-Elite
Background: Xrn1 exoribonuclease is the major mRNA degradation enzyme in Saccharomyces cerevisiae. In exponentially growing cells, Xrn1 is localised in the yeast cells and directs the degradation of mRNA molecules.
Tomas Grousl, Tomas Vomastek
doaj   +1 more source

Identification of Genes Potentially Regulated by Human Polynucleotide Phosphorylase (hPNPaseold-35) Using Melanoma as a Model [PDF]

, 2013
Human Polynucleotide Phosphorylase (hPNPaseold-35 or PNPT1) is an evolutionarily conserved 3′→5′ exoribonuclease implicated in the regulation of numerous physiological processes including maintenance of mitochondrial homeostasis, mtRNA import and aging ...
Bacolod, Manny D., Das, Swadesh K., Dasgupta, Santanu, Emdad, Luni, Sokhi, Upneet K.   +4 more
core   +2 more sources

Assessing The Role Of Multi-protein Complexes In Determining Phenotype [PDF]

, 2008
Understanding regulatory mechanisms in complex biological systems is an important challenge, in particular to understand disease mechanisms, and to discover new therapies and drugs. In this paper, we consider the important question of cellular regulation
Gentleman, Robert, Le Meur, Nolwenn
core   +1 more source

Exoribonuclease-Resistant RNAs Exist within both Coding and Noncoding Subgenomic RNAs

mBio, 2018
Many viruses produce protein-coding and noncoding subgenomic RNAs (sgRNAs) that are critical for infection. A recently discovered pathway for viral sgRNA production uses exoribonuclease-resistant RNAs (xrRNAs), discrete folded RNA elements that block the
Anna-Lena Steckelberg, Quentin Vicens, Jeffrey S. Kieft   +2 more
doaj   +1 more source