Results 91 to 100 of about 14,418 (193)

XRN1-Resistant Elements Are Located in the 3′-Terminal Regions of Certain Genome Segments of Jingmenviruses

open access: yesViruses
Jingmenviruses have been identified over the past decade. During this period, significant advancements have been made in understanding their diversity, biology, and genomic functionality.
Egor V. Okhezin   +3 more
doaj   +1 more source

Proteomic Profiling of Human Extracellular Vesicles Reveals Diagnostic Biomarkers for Colon Adenocarcinoma

open access: yesJournal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
Proteomic profiling of tissue explant‐ and plasma‐derived extracellular vesicles identified colon adenocarcinoma‐associated and healthy‐associated EV proteins. A 10‐protein EV panel enabled highly sensitive blood‐based detection of colon adenocarcinoma, showed marked postoperative changes, and retained performance in an independent validation cohort ...
Yura Seo   +33 more
wiley   +1 more source

Antivirals Targeting Coronavirus RNA‐Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID‐19 Clinical Trials

open access: yesMicrobial Biotechnology, Volume 19, Issue 4, April 2026.
The target sites of COVID‐19 antivirals discussed in the present opinion paper, namely the RNA dependent RNA polymerase Nsp12 and of the main viral protease Nsp5, are indicated by a red star in the overview of the replication cycle of coronavirus SARS‐CoV‐2.
Harald Brüssow
wiley   +1 more source

Correction: Evolutionarily Conserved 5'-3' Exoribonuclease Xrn1 Accumulates at Plasma Membrane-Associated Eisosomes in Post-Diauxic Yeast

open access: yes, 2015
Correction: Evolutionarily Conserved 5'-3' Exoribonuclease Xrn1 Accumulates at Plasma Membrane-Associated Eisosomes in Post-Diauxic ...
PLOS ONE (2189197)
core   +1 more source

RNA Degradation Assay Using RNA Exosome Complexes, Affinity-purified from HEK-293 Cells

open access: yesBio-Protocol, 2017
The RNA exosome complex plays a central role in RNA processing and regulated turnover. Present both in cytoplasm and nucleus, the exosome functions through associations with ribonucleases and various adapter proteins (reviewed in [Kilchert et al., 2016]).
Michal Domanski, John LaCava
doaj   +1 more source

Haplotype‐phased ‘Ottawa 3’ genome unravels differential reaction of apple rootstock roots to mixed viral infection

open access: yesThe Plant Journal, Volume 126, Issue 1, April 2026.
SUMMARY Viral diseases pose a significant threat to global apple (Malus spp.) production. While selecting appropriate rootstocks is a crucial strategy to mitigate their effects, the underlying mechanisms governing rootstock tolerance or sensitivity to viral infection at the root level remain underexplored.
Larissa Carvalho Costa   +8 more
wiley   +1 more source

Intermolecular base-pairing interactions, a unique topology and exoribonuclease-resistant noncoding RNAs drive formation of viral chimeric RNAs in plants [PDF]

open access: yes
In plants, exoribonuclease-resistant RNAs (xrRNAs) are produced by many viruses. Whereas xrRNAs contribute to the pathogenicity of these viruses, the role of xrRNAs in the virus infectious cycle remains elusive.Here, we show that xrRNAs produced by a ...
Poimenopoulou, Efstratia   +4 more
core   +1 more source

Judge, Jury, and Executioner: DXO Functions as a Decapping Enzyme and Exoribonuclease in Pre-mRNA Quality Control [PDF]

open access: yes, 2013
In this issue of Molecular Cell, Jiao et al. (2013) describe the mammalian enzyme DXO, which has pyrophosphohydrolase, decapping, and 5'-3' exoribonuclease activity and functions as an important checkpoint in cotranscriptional capping of RNA polymerase ...
Gross, John D, Mugridge, Jeffrey S
core   +1 more source

A novel role for the 3′-5′ exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth

open access: yes, 2016
In a complex organism, cell proliferation and apoptosis need to be precisely controlled in order for tissues to develop correctly. Excessive cell proliferation can lead to diseases such as cancer. We have shown that the exoribonuclease Dis3L2 is required
Christopher I. Jones (8751882)   +9 more
core   +2 more sources

Arenaviridae exoribonuclease presents genomic RNA edition capacity [PDF]

open access: yes, 2019
Abstract The Arenaviridae is a large family of viruses causing both acute and persistent infections and causing significant public health concerns in afflicted regions. A “trademark” of infection is the quick and efficient immuno-suppression mediated in part by a 3’-5’ RNA ...
Elsie Yekwa   +7 more
openaire   +2 more sources

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