Results 71 to 80 of about 14,418 (193)

Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs

WIREs RNA, Volume 17, Issue 4, July/August 2026.
NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind, Samira K. Bell, Carol S. Lutz   +2 more
wiley   +1 more source

Pentatricopeptide repeat proteins in crops: Advances in functional mechanisms and breeding applications

Journal of Integrative Plant Biology, Volume 68, Issue 7, Page 1973-2000, July 2026.
Pentatricopeptide repeat proteins coordinate nucleus‐organelle communication by modulating RNA metabolism within chloroplasts and mitochondria. This review highlights how they control critical processes like photosynthesis, seed development, fertility restoration, and stress survival in crops, and explores their potential as programmable tools for RNA ...
Mingming Wu, Maohong Cai, Rongrong Zhai, Jing Ye, Guofu Zhu, Faming Yu, Shenghai Ye, Xiaoming Zhang   +7 more
wiley   +1 more source

The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy [PDF]

Autophagy, 2018
Macroautophagy/autophagy is a conserved catabolic process that promotes survival during stress. Autophagic dysfunction is associated with pathologies such as cancer and neurodegenerative diseases. Thus, autophagy must be strictly modulated at multiple levels (transcriptional, post-transcriptional, translational and post-translational) to prevent ...
Elizabeth Delorme-Axford, Emma Abernathy, Nicholas J. Lennemann, Amélie Bernard, Aileen Ariosa, Carolyn B. Coyne, Karla Kirkegaard, Daniel J. Klionsky   +7 more
openaire   +3 more sources

Elastic Coupling Between RNA Degradation and Unwinding by an Exoribonuclease [PDF]

Science, 2012
Loading a Spring To regulate cellular RNA levels, transcription must be balanced by RNA degradation. An important player is the exosome, which can unwind and degrade structured RNA. Lee et al. (p.
Gwangrog, Lee, Matthew A, Bratkowski, Fang, Ding, Ailong, Ke, Taekjip, Ha   +4 more
openaire   +2 more sources

Crystal Structure of RNase T, an Exoribonuclease Involved in tRNA Maturation and End Turnover [PDF]

, 2007
SummaryThe 3′ processing of most bacterial precursor tRNAs involves exonucleolytic trimming to yield a mature CCA end. This step is carried out by RNase T, a member of the large DEDD family of exonucleases.
Cymborowski, Marcin, Zheng, Heping, Zuo, Yuhong, Savchenko, Alexei, Malhotra, Arun, Minor, Wladek, Skarina, Tatiana, Wang, Yong, Chruszcz, Maksymilian   +8 more
core   +1 more source

Investigation of the Relationship Between Ovine Selection Signature DIS3 Like 3′‐5′ Exoribonuclease 2 (DIS3L2) Gene and Weaning Weight and Average Daily Gain Until Weaning in Lambs

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The growing demand for animal products, combined with declining livestock production due to urbanization and climate change, underscores the need for sustainable breeding strategies. In sheep production, liveweight and weight gain until weaning are key economic traits.
Bilal Akyüz, Fadime Daldaban, Davut Bayram, Ferda Karakuş, Mustafa Özdemir, Emre Şirin, Korhan Arslan, Mehmet Ulas Cinar   +7 more
wiley   +1 more source

A DIStinctively novel exoribonuclease that really likes U

The EMBO Journal, 2013
Regulated degradation plays a major role in determining the levels of both non-coding (miRNA) and coding (mRNA) transcripts. Thus, insights into the factors and pathways that influence this process have broad, interdisciplinary implications. New findings by Malecki et al (2013), Lubas et al (2013), and Chang et al (2013) identify the protein Dis3L2 as ...
Imed E, Gallouzi, Jeffrey, Wilusz
openaire   +3 more sources

Exoribonuclease-resistant RNAs in tick-borne flaviviruses

Tick-borne flaviviruses (TBF) are a group of emerging and re-emerging pathogens that affect large geographic regions, including Europe, Asia, North America, and Africa, posing a major public health threat. A critical aspect of their molecular biology and
Leonhard Sidl (18265671), Michael Wolfinger (7249694), Denis Skibinski (18265676), Hua-Ting Yao (18265692)   +3 more
core   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, Volume 13, Issue 27, 13 May 2026.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster

, 1998
In multicellular organisms, very little is known about the role of mRNA stability in development, and few proteins involved in degradation pathways have been characterized.
Linz, B., McCarthy, J. E G, Elgar, S. J., Marujo, P. E., Arraiano, C. M., De Lourdes Elias, M., Mccarthy, John, McClellan, J. A., Seago, J. E., Newbury, S. F., Till, D. D.   +10 more
core   +1 more source