Results 51 to 60 of about 4,960 (183)

Processing of RNA Containing 8-Oxo-7,8-Dihydroguanosine (8-oxoG) by the Exoribonuclease Xrn-1

Frontiers in Molecular Biosciences, 2021
Understanding how oxidatively damaged RNA is handled intracellularly is of relevance due to the link between oxidized RNA and the progression/development of some diseases as well as aging.
Cheyenne N. Phillips, Shawn Schowe, Conner J. Langeberg, Namoos Siddique, Erich G. Chapman, Marino J. E. Resendiz   +5 more
doaj   +1 more source

Alphavirus replication is fed by XRN1-mediated cellular mRNA degradation

, 2023
XRN1 is a key regulator of mRNA degradation, with proposed roles in viral infection. However, the exact function of XRN1 in infection remains poorly understood due to antagonistic results.
Hull, R., Ruscica, V. ; https://orcid.org/, Narayanan, S., Palmalux, N., Noerenberg, M., Davis, I., Rolande De Lauren, Z., Embarc-Buh, A., Pelechano, V., Kamel, W., Robertson, D., Gu, Q., Castello, A., Igreja, C. ; https://orcid.org/, Hugh, J., Iselin, L., Mohammed, S.   +16 more
core  

Zirkuläre, Photogeschützte mRNA für Lichtinduzierte Aktivierung der Translation zu späten Zeitpunkten

Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.
Eine klickbare, photogeschützte 5′‐Kappe (CyCliCap) zur Herstellung von zyklischer, Click‐Cap enthaltender mRNA (Cyclic Click Cap‐mRNA), die bis zur Bestrahlung beachtlich stabil und translational stumm ist, ermöglicht die Aktivierung der Translation in Zellen zu späten Zeitpunkten mittels Lichts. ZUSAMMENFASSUNG mRNA ist eine neue Impfstofftechnologie
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Xrn1 associates with heat-induced stress granules.

, 2015
Localization patterns of Xrn1-GFP and eIF3a-RFP in exponentially growing cells (strain CRY2104) at 30°C (A) and upon heat stress at 46°C (B) were correlated.
Tomas Grousl (382128), Miroslava Opekarová (172850), Jiri Hasek (382134), Jan Malinsky (172856), Vendula Stradalova (172840)   +4 more
core   +1 more source

Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
A clickable photo‐caged 5′ cap (CyCliCap) allows to make Cyclic Click Cap‐containing mRNA (CyCliCap‐mRNA) which is remarkably stable and translationally muted until irradiated, allowing for late‐stage activation of translation in cells by light. ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent ...
Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz, Martin Sumser, Yasuaki Kimura, Hiroshi Abe, Andrea Rentmeister   +6 more
wiley   +1 more source

Xrn1-resistant RNA structures are well-conserved within the genus flavivirus [PDF]

RNA Biology, 2020
Subgenomic RNAs are produced by several RNA viruses through incomplete degradation of their genomic RNA by the exoribonuclease Xrn1, and have been shown to be essential for viral growth and pathogenicity. Within the flavivirus genus of the Flaviviridae family, two distinct classes of Xrn1-resistant RNA motifs have been proposed; one for mosquito-borne ...
Ivar W. Dilweg, Assia Bouabda, Tim Dalebout, Alexander P. Gultyaev, Peter J. Bredenbeek, R. C. L. Olsthoorn   +5 more
openaire   +4 more sources

Coordinated destruction of cellular messages in translation complexes by the gammaherpesvirus host shutoff factor and the mammalian exonuclease Xrn1.

PLoS Pathogens, 2011
Several viruses encode factors that promote host mRNA degradation to silence gene expression. It is unclear, however, whether cellular mRNA turnover pathways are engaged to assist in this process. In Kaposi's sarcoma-associated herpesvirus this phenotype
Sergio Covarrubias, Marta M Gaglia, G Renuka Kumar, Wesley Wong, Andrew O Jackson, Britt A Glaunsinger   +5 more
doaj   +1 more source

A role of Sep1 (= Kem1, Xrn1) as a microtubule‐associated protein in Saccharomyces cerevisiae. [PDF]

The EMBO Journal, 1995
Saccharomyces cerevisiae cells lacking the SEP1 (also known as XRN1, KEM1, DST2, RAR5) gene function exhibit a number of phenotypes in cellular processes related to microtubule function. Mutant cells show increased sensitivity to the microtubule-destabilizing drug benomyl, increased chromosome loss, a karyogamy defect, impaired spindle pole body ...
H, Interthal, C, Bellocq, J, Bähler, V I, Bashkirov, S, Edelstein, W D, Heyer   +5 more
openaire   +2 more sources

Discoveries of Exoribonuclease-Resistant Structures of Insect-Specific Flaviviruses Isolated in Zambia

Viruses, 2020
To monitor the arthropod-borne virus transmission in mosquitoes, we have attempted both to detect and isolate viruses from 3304 wild-caught female mosquitoes in the Livingstone (Southern Province) and Mongu (Western Province) regions in Zambia in 2017. A
Christida E. Wastika, Hayato Harima, Michihito Sasaki, Bernard M. Hang’ombe, Yuki Eshita, Yongjin Qiu, William W. Hall, Michael T. Wolfinger, Hirofumi Sawa, Yasuko Orba   +9 more
doaj   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source