Results 41 to 50 of about 4,960 (183)
Wolbachia-mediated virus blocking in mosquito cells is dependent on XRN1-mediated viral RNA degradation and influenced by viral replication rate. [PDF]
PLoS Pathogens, 2018 Wolbachia is currently being developed as a novel tool to block the transmission of dengue viruses (DENV) by Aedes aegypti. A number of mechanisms have been proposed to explain the DENV-blocking phenotype in mosquitoes, including competition for fatty ...
Saijo Thomas +3 more
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Dynamic “Cap”‐abilities of P‐bodies and the XRN1‐EDC4 axis
The EMBO Journal, 2023 RNA turnover regulates the quality and quantity of cellular gene expression through a coordinated cavalcade of enzymes, factors, and phase transitions. In this issue, Brothers et al reveal the importance of balanced communication between the Xrn1 exonuclease and the EDC4 decapping factor to coordinate P-body dynamics and maintain cellular fitness.
Lauren E Malsick, Jeffrey Wilusz
openaire +2 more sources
Nature Communications, 2021 Exoribonuclease-resistant RNAs (xrRNAs) are RNA elements that block the exoribonucleolytic degradation of RNA. Here the authors show how a long-range pseudoknot length modulates the Mg2+-dependence of flaviviral xrRNA’s folding, conformational dynamics ...
Xiaolin Niu +6 more
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Ty3 Retrotransposon Hijacks Mating Yeast RNA Processing Bodies to Infect New Genomes. [PDF]
PLoS Genetics, 2015 Retrotransposition of the budding yeast long terminal repeat retrotransposon Ty3 is activated during mating. In this study, proteins that associate with Ty3 Gag3 capsid protein during virus-like particle (VLP) assembly were identified by mass ...
Virginia Bilanchone +10 more
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Xrn1 biochemically associates with eisosome proteins after the post diauxic shift in yeast
, 2023 International audiencemRNA degradation is one of the main steps of gene expression, and a key player is the 5’-3’ exonuclease Xrn1. In Saccharomyces cerevisiae, it was previously shown, by a microscopy approach, that Xrn1 is located to different cellular
Meyer, Laura +5 more
core +1 more source
eLife, 2022 A single Dcp1–Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5′ to 3′ decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive.
Feng He, Chan Wu, Allan Jacobson
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Cytoplasmic 5’-3’ exonuclease Xrn1p is also a genome-wide transcription factor in yeast
Frontiers in Genetics, 2014 The 5’ to 3’ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects ...
Daniel A Medina +5 more
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Exonuclease Xrn1 regulates TORC1 signaling in response to SAM availability
, 2023 Abstract Autophagy is a conserved process of cellular self-digestion that promotes survival during nutrient stress. In yeast, methionine starvation is sufficient to induce autophagy. One pathway of autophagy induction is governed by the SEACIT complex, which regulates TORC1 activity in response to amino acids through the Rag GTPases Gtr1 and Gtr2 ...
Madeline M. McGinnis +3 more
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PLoS ONE, 2018 Flaviviruses accumulate abundant subgenomic RNA (sfRNA) in infected cells. It has been reported that sfRNA results from stalling of host 5'-to-3' exoribonuclease XRN1 at the highly structured RNA of the 3' untranslated region (UTR).
Yi-Shiuan Chen +4 more
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RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA
eLife, 2014 Dengue virus is a growing global health threat. Dengue and other flaviviruses commandeer the host cell’s RNA degradation machinery to generate the small flaviviral RNA (sfRNA), a noncoding RNA that induces cytopathicity and pathogenesis.
Erich G Chapman +3 more
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