Results 21 to 30 of about 7,632 (199)
Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast. [PDF]
PLoS ONE, 2015 Regulation of gene expression on the level of translation and mRNA turnover is widely conserved evolutionarily. We have found that the main mRNA decay enzyme, exoribonuclease Xrn1, accumulates at the plasma membrane-associated eisosomes after glucose ...
Tomas Grousl +4 more
doaj +1 more source
Biochemical Characterization of Yeast Xrn1
Biochemistry, 2020 Messenger RNA degradation is an important component of overall gene expression. During the final step of eukaryotic mRNA degradation, exoribonuclease 1 (Xrn1) carries out 5' → 3' processive, hydrolytic degradation of RNA molecules using divalent metal ion catalysis.
Conner J. Langeberg +5 more
openaire +4 more sources
Nature Communications, 2022 Subgenomic flaviviral RNAs (sfRNAs) are produced by pathogenic flaviviruses to counteract the host antiviral response. sfRNAs are products of incomplete degradation of viral RNA by the host exoribonuclease XRN1 which stalls on XRN1-resistant structural ...
Andrii Slonchak +12 more
doaj +1 more source
Structural features of an Xrn1-resistant plant virus RNA [PDF]
RNA Biology, 2019 Xrn1 is a major 5ʹ-3ʹ exoribonuclease involved in the RNA metabolism of many eukaryotic species. RNA viruses have evolved ways to thwart Xrn1 in order to produce subgenomic non-coding RNA that affects the hosts RNA metabolism. The 3ʹ untranslated region of several beny- and cucumovirus RNAs harbors a so-called ‘coremin’ motif that is required for Xrn1 ...
Dilweg, I.W. +2 more
openaire +3 more sources
Scientific Reports, 2023 RNAs that are able to prevent degradation by the 5’–3’ exoribonuclease Xrn1 have emerged as crucial structures during infection by an increasing number of RNA viruses.
Ivar W. Dilweg +2 more
doaj +1 more source
Subgenomic Flaviviral RNAs of Dengue Viruses
Viruses, 2023 Subgenomic flaviviral RNAs (sfRNAs) are produced during flavivirus infections in both arthropod and vertebrate cells. They are undegraded products originating from the viral 3′ untranslated region (3′ UTR), a result of the action of the host 5′-3 ...
Yi Liu, Wuxiang Guan, Haibin Liu
doaj +1 more source
A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation [PDF]
, 2019 Plus-strand RNA viruses can accumulate viral RNA degradation products during infections. Some of these decay intermediates are generated by the cytosolic 5′-to-3′ exoribonuclease Xrn1 (mammals and yeast) or Xrn4 (plants) and are formed when the enzyme ...
Chaminda, Gunawardene D. +2 more
core +1 more source
All genera of Flaviviridae host a conserved Xrn1-resistant RNA motif [PDF]
RNA Biology, 2021 After infection by flaviviruses like Zika and West Nile virus, eukaryotic hosts employ the well-conserved endoribonuclease Xrn1 to degrade the viral genomic RNA. Within the 3' untranslated regions, this enzyme encounters intricate Xrn1-resistant structures.
Ivar W. Dilweg +5 more
openaire +5 more sources
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1 [PDF]
, 2015 Ribonucleases are critically important in many cellular and developmental processes and defects in their expression are associated with human disease.
Amy L. Pashler +5 more
core +1 more source