Xrn1/Pacman affects apoptosis and regulates expression of hid and reaper [PDF]
Biology Open, 2015 Programmed cell death, or apoptosis, is a highly conserved cellular process that is crucial for tissue homeostasis under normal development as well as environmental stress.
Joseph A. Waldron +8 more
doaj +10 more sources
The roles of the exoribonucleases DIS3L2 and XRN1 in disease [PDF]
Biochemical Society Transactions, 2016 RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases which are critical for the degradation of cytoplasmic RNAs ...
Jones, Christopher I +3 more
core +4 more sources
Investigating the correlation between Xrn1-resistant RNAs and frameshifter pseudoknots
RNA Biology, 2023 Xrn1-resistant RNA structures are multifunctional elements employed by an increasing number of RNA viruses. One of such elements is the coremin motif, discovered in plant virus RNAs, of which the structure has been hypothesized to form a yet unelucidated
Ivar W. Dilweg +3 more
doaj +4 more sources
Cytoplasmic 5’-3’ exonuclease Xrn1p is also a genome-wide transcription factor in yeast [PDF]
Frontiers in Genetics, 2014 The 5’ to 3’ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects ...
Daniel A Medina +5 more
doaj +5 more sources
Xrn1 Exoribonuclease—An Intrinsic Marker of Yeast Population Growth
Frontiers in Bioscience-EliteBackground: Xrn1 exoribonuclease is the major mRNA degradation enzyme in Saccharomyces cerevisiae. In exponentially growing cells, Xrn1 is localised in the yeast cells and directs the degradation of mRNA molecules.
Tomas Grousl, Tomas Vomastek
doaj +3 more sources
The mRNA degradation factor Xrn1 regulates transcription elongation in parallel to Ccr4 [PDF]
Nucleic Acids Research, 2019 Co-transcriptional imprinting of mRNA by Rpb4 and Rpb7 subunits of RNA polymerase II (RNAPII) and by the Ccr4–Not complex conditions its posttranscriptional fate.
Begley, Victoria Sarah +10 more
core +9 more sources
The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1 [PDF]
G3: Genes, Genomes, Genetics, 2018 The highly conserved DNA damage response (DDR) pathway monitors the genomic integrity of the cell and protects against genotoxic stresses. The apical kinases, Mec1 and Tel1 (ATR and ATM in human, respectively), initiate the DNA damage signaling cascade ...
Jessica P. Lao +7 more
doaj +5 more sources
XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts.
PLoS Pathogens, 2016 In eukaryotes, the degradation of cellular mRNAs is accomplished by Xrn1 and the cytoplasmic exosome. Because viral RNAs often lack canonical caps or poly-A tails, they can also be vulnerable to degradation by these host exonucleases.
Paul A Rowley +4 more
doaj +3 more sources
Correction: XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts. [PDF]
PLoS Pathogens, 2016 [This corrects the article DOI: 10.1371/journal.ppat.1005890.].
PLOS Pathogens Staff
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Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences [PDF]
Nature Communications, 2016 Degradation of messenger RNA is a key regulatory step in controlling eukaryotic gene expression. Here the authors present xrFrag, a molecular tool to interrogate the extent and directionality of mRNA turnover by the detection of stabilized decay ...
Volker Boehm +3 more
doaj +3 more sources