Results 11 to 20 of about 4,960 (183)
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis [PDF]
iScience, 2021 Summary: Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity.
Shohei Takaoka +8 more
doaj +6 more sources
Xrn1 Exoribonuclease—An Intrinsic Marker of Yeast Population Growth
Frontiers in Bioscience - EliteBackground: Xrn1 exoribonuclease is the major mRNA degradation enzyme in Saccharomyces cerevisiae. In exponentially growing cells, Xrn1 is localised in the yeast cells and directs the degradation of mRNA molecules.
Tomáš Vomastek, Tomáš Grousl
exaly +5 more sources
Biochemical Characterization of Yeast Xrn1 [PDF]
Biochemistry, 2020 Messenger RNA degradation is an important component of overall gene expression. During the final step of eukaryotic mRNA degradation, exoribonuclease 1 (Xrn1) carries out 5' → 3' processive, hydrolytic degradation of RNA molecules using divalent metal ion catalysis.
Conner J. Langeberg +5 more
core +6 more sources
The Yeast DNA Damage Checkpoint Kinase Rad53 Targets the Exoribonuclease, Xrn1 [PDF]
G3: Genes, Genomes, Genetics, 2018 The highly conserved DNA damage response (DDR) pathway monitors the genomic integrity of the cell and protects against genotoxic stresses. The apical kinases, Mec1 and Tel1 (ATR and ATM in human, respectively), initiate the DNA damage signaling cascade ...
David Toczyski +2 more
exaly +7 more sources
The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins [PDF]
Nature Communications, 2019 The exonuclease Xrn1 mediates crosstalk between transcription and mRNA decay in yeast. Here the authors demonstrate that Xrn1 promotes translation of mRNAs encoding membrane proteins, coupling transcription, translation, and mRNA decay.
Bernat Blasco-Moreno +12 more
doaj +7 more sources
Structural features of an Xrn1-resistant plant virus RNA [PDF]
RNA Biology, 2019 Xrn1 is a major 5ʹ-3ʹ exoribonuclease involved in the RNA metabolism of many eukaryotic species. RNA viruses have evolved ways to thwart Xrn1 in order to produce subgenomic non-coding RNA that affects the hosts RNA metabolism. The 3ʹ untranslated region of several beny- and cucumovirus RNAs harbors a so-called ‘coremin’ motif that is required for Xrn1 ...
Dilweg, I.W. +2 more
openaire +5 more sources
Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast. [PDF]
PLoS ONE, 2015 Regulation of gene expression on the level of translation and mRNA turnover is widely conserved evolutionarily. We have found that the main mRNA decay enzyme, exoribonuclease Xrn1, accumulates at the plasma membrane-associated eisosomes after glucose ...
Tomas Grousl +4 more
doaj +2 more sources
Xrn1 is a deNADding enzyme modulating mitochondrial NAD-capped RNA [PDF]
Nature Communications, 2022 The cytoplasmic Xrn1 protein has long been established as the predominate 5′ to 3′ exoribonuclease that cleaves RNAs with an unprotected 5′ monophosphate end. Here the authors demonstrate Xrn1 can also degrade RNAs harboring the noncanonical nicotinamide
Sunny Sharma +5 more
doaj +5 more sources
The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy [PDF]
Autophagy, 2018 Macroautophagy/autophagy is a conserved catabolic process that promotes survival during stress. Autophagic dysfunction is associated with pathologies such as cancer and neurodegenerative diseases. Thus, autophagy must be strictly modulated at multiple levels (transcriptional, post-transcriptional, translational and post-translational) to prevent ...
Elizabeth Delorme-Axford +7 more
openaire +4 more sources
Structure of the 80S ribosome–Xrn1 nuclease complex
Nature Structural & Molecular Biology, 2019 Messenger RNA (mRNA) homeostasis represents an essential part of gene expression, in which the generation of mRNA by RNA polymerase is counter-balanced by its degradation by nucleases. The conserved 5'-to-3' exoribonuclease Xrn1 has a crucial role in eukaryotic mRNA homeostasis by degrading decapped or cleaved mRNAs post-translationally and, more ...
Petr Tesina +10 more
openaire +3 more sources