Results 61 to 70 of about 4,960 (183)
The 5′ → 3′ exoribonuclease XRN1/Pacman and its functions in cellular processes and development
, 2012 XRN1 is a 5' ? 3' processive exoribonuclease that degrades mRNAs after they have been decapped. It is highly conserved in all eukaryotes, including homologs in Drosophila melanogaster (Pacman), Caenorhabditis elegans (XRN1), and Saccharomyces cerevisiae (
Christopher Iain Jones +5 more
core +2 more sources
Viruses, 2018 The RNA3 species of the beet necrotic yellow vein virus (BNYVV), a multipartite positive-stranded RNA phytovirus, contains the ‘core’ nucleotide sequence required for its systemic movement in Beta macrocarpa.
Alyssa Flobinus +9 more
doaj +1 more source
Scientific Reports, 2021 Senescence in placenta/fetal membranes is a normal phenomenon linked to term parturition. However, excessive senescence which may be induced by telomere attrition, has been associated with preeclampsia (PE). We hypothesized that the telomerase complex in
T. Lekva +11 more
doaj +1 more source
UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation
Advanced Science, Volume 13, Issue 48, 28 August 2026.ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro +7 more
wiley +1 more source
, 2018 (A-D) Insect Cellular mRNA stability is altered by DENV sfRNA. The half-life of ECR (A & B) and La (C&D) mRNA was determined in Aag2 and Aag2-wMel cells mock infected or infected with DENV after Actinomycin-D treatment by RT-qPCR.
Saijo Thomas (204009) +3 more
core +1 more source
Advanced Science, Volume 13, Issue 43, 3 August 2026.RNA structural profiling of Turnip Yellow Mosaic Virus by DMS‐MaPseq and DREEM analyses uncover that viral genome‐wide RSS is highly complicated and heterogeneous, with alternative RSSs widely distributed across the genome. Notably, the viral 3’ tRNA‐like structure adopts alternative conformations in vivo.
Jiaying Zhu +7 more
wiley +1 more source
Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs
WIREs RNA, Volume 17, Issue 4, July/August 2026.NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind +2 more
wiley +1 more source
Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome [PDF]
RNA, 2005 RNA interference (RNAi) is a conserved RNA silencing pathway that leads to sequence-specific mRNA decay in response to the presence of double-stranded RNA (dsRNA). Long dsRNA molecules are first processed by Dicer into 21–22-nucleotide small interfering RNAs (siRNAs).
Tamas I, Orban, Elisa, Izaurralde
openaire +2 more sources
The FASEB Journal, Volume 40, Issue 11, 15 June 2026.This study revealed a dose‐dependent miRNA buffering mechanism involving extracellular export and storage of miRNA on lipid droplets. The protein HuR facilitates miRNA buffering by dissociating miRNAs from Ago2 and promoting miRNA accumulation on lipid droplets or its extracellular export, depending on cellular requirements.
Sreemoyee Chakraborty +3 more
wiley +1 more source
PLoS Pathogens, 2015 We demonstrate that both Hepatitis C virus (HCV) and Bovine Viral Diarrhea virus (BVDV) contain regions in their 5' UTRs that stall and repress the enzymatic activity of the cellular 5'-3' exoribonuclease XRN1, resulting in dramatic changes in the ...
Stephanie L Moon +8 more
doaj +1 more source