Results 81 to 90 of about 7,632 (199)
Yeast RNase III triggers polyadenylation-independent transcription termination [PDF]
, 2009 Transcription termination of messenger RNA (mRNA) is normally achieved by polyadenylation followed by Rat1p-dependent 5'-3' exoribonuleolytic degradation of the downstream transcript.
Abou Elela, Sherif +5 more
core +1 more source
Small Nucleolar RNAs: Biological Functions and Diseases
MedComm, Volume 6, Issue 7, July 2025.The majority of snoRNAs are derived from the intron region of genes, besides to intronic snoRNAs, some snoRNAs are transcribed as independent genes, often by Pol II or III, these snoRNAs are called intergenic snoRNAs. All of these play a role in the occurrence and progression of various diseases through multiple functions.
Yi Wang +4 more
wiley +1 more source
Conceptual Modeling of mRNA Decay Provokes New Hypotheses [PDF]
, 2014 Biologists are required to integrate large amounts of data to construct a working model of the system under investigation. This model is often informal and stored mentally or textually, making it prone to contain undetected inconsistencies, inaccuracies,
Choder, Mordechai +4 more
core +3 more sources
Unraveling the Role of Topoisomerase 3β (TOP3B) in mRNA Translation and Human Disease
WIREs RNA, Volume 16, Issue 4, July/August 2025.The human genome encodes six topoisomerases—TOP1, TOP1mt, TOP2A, TOP2B, TOP3A, and TOP3B. The subcellular localization of each is shown. TOP3B, which harbors a bona fide RNA‐binding domain, predominantly localizes to the cytosol and is reported to function in mRNA translation and stability.
Julia E. Warrick, Michael G. Kearse
wiley +1 more source
Viruses, 2014 Flaviviruses are a large group of positive strand RNA viruses transmitted by arthropods that include many human pathogens such as West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus, dengue virus, and tick-borne encephalitis ...
Justin A. Roby +3 more
doaj +1 more source
FEBS Letters, Volume 599, Issue 9, Page 1222-1235, May 2025.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
Extracellular Vesicles Alter Trophoblast Function in Pregnancies Complicated by COVID‐19
Journal of Extracellular Vesicles, Volume 14, Issue 4, April 2025.ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and resulting coronavirus disease (COVID‐19) cause placental dysfunction, which increases the risk of adverse pregnancy outcomes. While abnormal placental pathology resulting from COVID‐19 is common, direct infection of the placenta is rare.
Thea N. Golden +12 more
wiley +1 more source
Genome-wide profiling of uncapped mRNA [PDF]
, 2012 Gene transcripts are under extensive posttranscriptional regulation, including the regulation of their stability. A major route for mRNA degradation produces uncapped mRNAs, which can be generated by decapping enzymes, endonucleases, and small RNAs ...
BD Gregory +9 more
core +2 more sources
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi +9 more
wiley +1 more source
Cytoplasmic RNA decay pathways - enzymes and mechanisms [PDF]
, 2016 RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work conducted over the last decades has defined the major mRNA decay pathways, as well as enzymes and their cofactors responsible for these processes. In contrast, our
Dziembowski, Andrzej +2 more
core +1 more source