Results 81 to 90 of about 4,960 (183)
ChemistryEurope, Volume 3, Issue 6, November 11, 2025.Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling +5 more
wiley +1 more source
Conserved Functions of LARP1 Proteins in Eukaryotes
WIREs RNA, Volume 16, Issue 6, November/December 2025.LARP1 proteins are evolutionary conserved, and their function is influenced by both independent and coordinated roles of the La Motif and DM15 region, with a net effect on mRNA translation and stability. ABSTRACT La and La‐related proteins (LARPs) are conserved RNA‐binding proteins that share a characteristic La motif (LaM) and have important functions
Farnaz Mansouri‐Noori +1 more
wiley +1 more source
The Exonuclease Xrn1 : a key regulator of gene expression under physiological and perturbed conditions [PDF]
, 2019 The highly conserved exonuclease Xrn1 plays a dual role in gene expression by degrading cellular mRNAs and promoting their transcription initiation and elongation.
Campos Mata, Leire de
core +1 more source
Role of 5’ - 3’ exoribonuclease Xrn1 in energy expenditure and control of obesity [PDF]
, 2020 Okinawa Institute of Science and Technology Graduate UniversityDoctor of PhilosophyGene expression of eukaryotes is regulated by various processes including mRNA degradation.
Takaoka, Shohei
core +1 more source
Viruses, 2014 Flaviviruses are a large group of positive strand RNA viruses transmitted by arthropods that include many human pathogens such as West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus, dengue virus, and tick-borne encephalitis ...
Justin A. Roby +3 more
doaj +1 more source
Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease
FASEB BioAdvances, Volume 7, Issue 11, November 2025.Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur +4 more
wiley +1 more source
Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.FTO regulates the translation of IGFBP3 by demethylating m6A sites in the 3′‐untranslated region of IGFBP3 mRNA. Binding of the m6A reader protein IMP3 to 3′UTR m6A sites in IGFBP3 mRNA promoted its localisation and sequestration in cellular organelles known as to P‐bodies, thereby suppressing IGFBP3 mRNA translation. IGFBP3 regulates activation of the
Haiyang Wang +7 more
wiley +1 more source
Uncovering a novel function of the exonuclease Xrn1 in viral and cellular mRNA translation [PDF]
, 2016 The exonuclease Xrn1 degrades messenger RNAs (mRNAs) and controls transcription. By using a model system that replicates brome mosaic virus (BMV) in yeast, here we show that Xrn1 promotes translation initiation of BMV RNA.
Blasco Moreno, Bernat
core +1 more source
Small Nucleolar RNAs: Biological Functions and Diseases
MedComm, Volume 6, Issue 7, July 2025.The majority of snoRNAs are derived from the intron region of genes, besides to intronic snoRNAs, some snoRNAs are transcribed as independent genes, often by Pol II or III, these snoRNAs are called intergenic snoRNAs. All of these play a role in the occurrence and progression of various diseases through multiple functions.
Yi Wang +4 more
wiley +1 more source
Unraveling the Role of Topoisomerase 3β (TOP3B) in mRNA Translation and Human Disease
WIREs RNA, Volume 16, Issue 4, July/August 2025.The human genome encodes six topoisomerases—TOP1, TOP1mt, TOP2A, TOP2B, TOP3A, and TOP3B. The subcellular localization of each is shown. TOP3B, which harbors a bona fide RNA‐binding domain, predominantly localizes to the cytosol and is reported to function in mRNA translation and stability.
Julia E. Warrick, Michael G. Kearse
wiley +1 more source