Results 101 to 110 of about 7,632 (199)

Unleashing viral mimicry: A combinatorial strategy to enhance the efficacy of PARP7 inhibitors

BioEssays, Volume 47, Issue 2, February 2025.
This review explores the potential of inducing a viral mimicry‐primed state by combining PARP7 inhibitors with drugs that promote the accumulation of self‐nucleic acids. This synergistic approach could enhance apoptosis and the immune response against cancer cells with elevated IFN‐stimulated gene (ISG) scores, providing a promising avenue for ...
Patrick Manetsch, Michael O. Hottiger
wiley   +1 more source

XRN1deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

, 2023
SummaryEmerging data suggest that induction of viral mimicry responses through activation of double-stranded RNA (dsRNA) sensors in cancer cells is a promising therapeutic strategy. One approach to induce viral mimicry is to target molecular regulators of dsRNA sensing pathways. Here, we show that the exoribonuclease XRN1 is a negative regulator of the
Tao Zou, Meng Zhou, Akansha Gupta, Patrick Zhuang, Alyssa R. Fishbein, Hope Y. Wei, Zhouwei Zhang, Andrew D. Cherniack, Matthew Meyerson   +8 more
openaire   +2 more sources

The Mysterious World of Non‐Canonical Caps – What We Know and Why We Need New Sequencing Techniques

ChemBioChem, Volume 26, Issue 3, February 1, 2025.
This review describes sophisticated methodologies such as LC–MS that enabled the identification of 5’ non‐canonical RNA caps and also surveys so far developed sequencing methods, evaluating their advantages and disadvantages. It emphasizes the need for developing new, reliable sequencing techniques to identify RNA types with non‐canonical caps enabling
Flaminia Mancini, Hana Cahova
wiley   +1 more source

Transcriptomic screen for DIS3 and DIS3L1 exosome subunits associated functional networks in colorectal cancer [PDF]

, 2015
The final step of cytoplasmic mRNA degradation proceeds in either a 5’-3’ direction, catalyzed by XRN1, or in a 3’-5’ direction catalyzed by the exosome. In yeast, DIS3/Rrp44 protein is the catalytic subunit of the exosome.
Costa, Paulo, Gama-Carvalho, Margarida, Romão, Luísa   +2 more
core  

Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing [PDF]

, 2010
Most metazoan microRNA (miRNA) target sites have perfect pairing to the seed region, located near the miRNA 5′ end. Although pairing to the 3′ region sometimes supplements seed matches or compensates for mismatches, pairing to the central region has been
Addo-Quaye, Alemán, Alena Shkumatava, Allen, Allen, Ameres, Anderson, Appel, Babiarz, Baek, Bartel, Bartel, Birmingham, Blanchette, Chanseok Shin, Chiang, David P. Bartel, Davis, Elbashir, Elbashir, Farh, Filipowicz, Friedman, German, Giraldez, Gregory, Grimson, Grimson, Günther, H. Rosaria Chiang, Haley, Hutvágner, Jackson, Jackson, Jackson, Jin-Wu Nam, Jones-Rhoades, Jones-Rhoades, Kadener, Kamal, Krützfeldt, Kyle Kai-How Farh, Lal, Lewis, Lewis, Lim, Lim, Liu, Llave, Mallory, Maniataki, Martinez, Meister, Miyoshi, Orban, Rajagopalan, Rand, Rhead, Rodriguez, Schwarz, Schwarz, Selbach, Serra, Shin, Souret, Stark, Wang, Wang, Yekta   +68 more
core   +2 more sources

Processing of preribosomal RNA in Saccharomyces cerevisiae [PDF]

, 2015
Most, if not all RNAs, are transcribed as precursors that require processing to gain functionality. Ribosomal RNAs (rRNA) from all organisms undergo both exo- and endonucleolytic processing.
Cruz, Jesús de la, Fernández-Pevida, Antonio, Kressler, Dieter   +2 more
core  

Genome-wide studies of mRNA synthesis and degradation in eukaryotes [PDF]

, 2012
In recent years, the use of genome-wide technologies has revolutionized the study of eukaryotic transcription producing results for thousands of genes at every step of mRNA life.
Adelman, Airoldi, Alberola, Alon, Aragon, Arava, Baugh, Bernstein, Berretta, Carrillo Oesterreich, Castells-Roca, Chang, Chatenay-Lapointe, Choder, Churchman, Core, Dahan, Doma, Dori-Bachash, Exinger, Fan, Fan, Farago, Filipovska, Galburt, García-Martínez, Gerber, Glesne, Goler-Baron, Grigull, Guenther, Guo, Hah, Harel-Sharvit, Hayles, Hirayoshi, Hogan, Holstege, Jona, José E. Pérez-Ortín, Keene, Kenzelmann, Kim, Kim, Kireeva, Kruk, Kuehner, Kurischko, Kwapisz, Lahudkar, Lardenois, Lefrancois, Legen, Lola de Miguel-Jiménez, Lotan, Lotan, Martens, Mason, Mavrich, Mayer, Miller, Molin, Molina-Navarro, Morillo-Huesca, Muse, Neil, Nelson, Parker, Pelechano, Pelechano, Pelechano, Perales, Pérez-Ortín, Pérez-Ortín, Pérez-Ortín, Rabani, Radonjic, Rodriguez-Gil, Romero-Santacreu, Schwanhausser, Sebastián Chávez, Selitrennik, Selth, Shalem, Shalem, Shema, Slavov, Struhl, Tenenbaum, Terzi, Tous, van Bakel, van Dijk, Venters, Vergara, Voliotis, Wade, Wang, Warner, Wei, Wilbert, Xu, Yassour, Zeitlinger   +103 more
core   +2 more sources

The role of RNA Polymerase II-dependent transcription elongation in the cross-talk between mRNA synthesis and decay. [PDF]

, 2018
The main molecule in gene expression is messenger RNA (mRNA) which transfers the information contained in genes in the nucleus to the cytoplasm where it is translated into proteins that carry out cellular functions. mRNA levels are determined through its
Begley, Victoria Sarah
core  

Regulation of cytoplasmic RNA stability: lessons from drosophila [PDF]

, 2018
The process of RNA degradation is a critical level of regulation contributing to the control of gene expression. In the last two decades a number of studies have shown the specific and targeted nature of RNA decay and its importance in maintaining ...
Abdelmohsen, Allmang, Ameres, An, Antic, Astuti, Baccarini, Bakheet, Bakheet, Bakheet, Bassett, Bazzini, Berezikov, Bitetti, Boczonadi, Bonneau, Bortolamiol-Becet, Braun, Brown, Burroughs, Cairrao, Cairrao, Callahan, Carballo, Chang, Chang, Chapman, Chapman, Cheadle, Chen, De Almeida, De Lella Ezcurra, Decker, Di Donato, Ding, Duffy, Eberle, Eckmann, Eggens, Eulalio, Faehnle, Fenger-Gron, Forstemann, Frazao, Garneau, Gatfield, Graham, Graham, Grima, Groen, Gudipati, Haas, Hales, Han, Han, Heo, Hopkins, Hou, Iwasaki, Jonas, Jones, Jones, Jones, Juvvuna, Kaberdin, Kadaba, Kahvejian, Katoh, Kim, Kim, Kinoshita, Kiss, Kowalinski, Larimer, Lebreton, Lee, Li, Lim, Lin, Liu, Londin, Lowell, Lubas, Makino, Malecki, Malet, Mamolen, Marin-Vicente, Maryati, Mata, Mitchell, Modepalli, Molleston, Moon, Morris, Mullen, Murakami, Murray, Nagarajan, Newbury, Ng, Nishioka, Ohkura, Okada, Orban, Pandey, Park, Pashler, Peng, Perez-Ortin, Pfeiffer, Pirouz, Preker, Presnyak, Rehwinkel, Reimao-Pinto, Reimao-Pinto, Reis, Reiter, Rissland, Rose, Russo, Schaeffer, Schaeffer, Schaeffer, Schertel, Schneider, Schneider, Schneider, Schoenberg, Sharif, Sinturel, Smith, Snee, Spasic, Staals, Steinbrunn, Suh, Synowsky, Temme, Temme, Tharun, Thomas, Till, Tomari, Tomecki, Tomecki, Towler, Towler, Towler, Ustianenko, Vallejo, Vindry, Wahle, Waldron, Wan, Wasmuth, Wei, Wells, Wolf, Wyers, Wyman, Yamashita, Zabolotskaya, Zhang   +164 more
core   +1 more source

Pervasive translation of Xrn1-sensitive unstable long non-coding RNAs in yeast

RNA
Despite being predicted to lack coding potential, cytoplasmic long non-coding (lnc)RNAs can associate with ribosomes. However, the landscape and biological relevance of lncRNAs translation remains poorly studied. In yeast, cytoplasmic Xrn1-sensitive lncRNAs (XUTs) are targeted by the Nonsense-Mediated mRNA Decay (NMD), suggesting a translation ...
Andjus, Sara, Szachnowski, Ugo, Vogt, Nicolas, Gioftsidi, Stamatia, Hatin, Isabelle, Cornu, David, Papadopoulos, Chris, Lopes, Anne, Namy, Olivier, Wery, Maxime, Morillon, Antonin   +10 more
openaire   +3 more sources