Results 91 to 100 of about 7,632 (199)
WIREs RNA, Volume 16, Issue 2, March/April 2025.Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus +3 more
wiley +1 more source
Synaptic control of mRNA translation by reversible assembly of XRN1 bodies
Journal of Cell Science, 2015 Repression of mRNA translation is linked to the formation of specific cytosolic foci such as Stress Granules (SGs) and Processing Bodies (PBs), which store or degrade mRNAs. In neurons, synaptic activity regulates translation at the postsynapse and this is important for plasticity.
Luchelli, Luciana +2 more
openaire +3 more sources
20S RNA Narnavirus Defies the Antiviral Activity of SKI1/XRN1 in Saccharomyces cerevisiae [PDF]
Journal of Biological Chemistry, 2008 20S RNA virus is a persistent positive strand RNA virus found in Saccharomyces cerevisiae. We previously observed that the virus generated in vivo from a launching vector possessed the correct RNA termini without extra sequences. Here we present evidence that the SKI1/XRN1 5'-exonuclease plays a major role in the elimination of the non-viral upstream ...
Esteban, Rosa +2 more
openaire +3 more sources
Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation
WIREs RNA, Volume 16, Issue 2, March/April 2025.GEMIN5 structural domains. Overview of GEMIN5's role in snRNP assembly and translation regulatory events. ABSTRACT GEMIN5 is a predominantly cytoplasmic protein, initially identified as a member of the survival of motor neurons (SMN) complex. In addition, this abundant protein modulates diverse aspects of RNA‐dependent processes, executing its ...
Encarnacion Martinez‐Salas +2 more
wiley +1 more source
Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes [PDF]
, 2017 The genus Flavivirus comprises a large number of small, positive-sense single-stranded, RNA viruses able to replicate in the cytoplasm of certain arthropod and/or vertebrate host cells.
Berzal-Herranz, Alfredo +3 more
core +1 more source
Dysregulated ribosome quality control in human diseases
The FEBS Journal, Volume 292, Issue 5, Page 936-959, March 2025.Ensuring the synthesis of full‐length, correctly folded proteins is vital for maintaining homeostasis. If a translating ribosome stalls, the trailing ribosomes collide into it, which if left unresolved leads to deleterious effects on the cell due to the accumulation of protein aggregates.
Tom McGirr +2 more
wiley +1 more source
A novel role for the 3′-5′ exoribonuclease Dis3L2 in controlling cell proliferation and tissue growth [PDF]
, 2016 In a complex organism, cell proliferation and apoptosis need to be precisely controlled in order for tissues to develop correctly. Excessive cell proliferation can lead to diseases such as cancer. We have shown that the exoribonuclease Dis3L2 is required
Benjamin P. Towler +5 more
core +2 more sources
Principles and effects of microRNA-mediated post-transcriptional gene regulation [PDF]
, 2006 MicroRNAs (miRNAs) are abundant regulatory RNAs involved in the regulation of many key biological processes. Recent advances in understanding the mechanism of RNA interference and miRNA-mediated mechanisms shed light on major principals of the formation ...
Engels, BM, Hutvagner, G
core +1 more source
Viral mimicry evasion: a new role for oncogenic KRAS mutations
Molecular Oncology, Volume 19, Issue 2, Page 271-274, February 2025.“Viral mimicry” is a potent anticancer mechanism involving innate immune activation by endogenous nucleic acids like double‐stranded RNA (dsRNA). Zhou and colleagues report viral mimicry evasion as a novel function of oncogenic KRAS mutations by suppressing the RNA helicase DDX60, leading to poor immune checkpoint therapy responses.
Raymond Chen +2 more
wiley +1 more source
Novel mRNA-silencing bodies at the synapse: A never-ending story
Communicative & Integrative Biology, 2016 Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs.
María Gabriela Thomas +1 more
doaj +1 more source