Results 91 to 100 of about 4,960 (183)
, 2021 The highly conserved exonuclease Xrn1 plays a dual role in gene expression by degrading cellular mRNAs and promoting their transcription initiation and elongation.
Campos Mata, Leire de, 1991-
core
, 2023 HEK293 cells were transfected with mCh-XRN1(1232–1706) alone (lane 1), mCh-XRN1(1232–1706) and GFP-EDC4(630–1437) (lane 2), or mCh-XRN1(1232–1706) and GFP-EDC4 (lane 3).
Claire O. Sinow (14725282) +3 more
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FEBS Letters, Volume 599, Issue 9, Page 1222-1235, May 2025.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source
Novel mRNA-silencing bodies at the synapse: A never-ending story
Communicative & Integrative Biology, 2016 Several cellular responses depend on translational regulation and in most cases, this involves the formation of cytoplasmic granules that contain repressed mRNAs.
María Gabriela Thomas +1 more
doaj +1 more source
, 2021 XRN1 is a highly conserved exoribonuclease which degrades uncapped RNAs in a 5'-3' direction. Degradation of RNAs by XRN1 is important in many cellular and developmental processes and is relevant to human disease. Studies in D.
Sarah Newbury (4461334) +5 more
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The roles of the exoribonucleases DIS3L2 and XRN1 in disease
, 2016 RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases which are critical for the degradation of cytoplasmic RNAs ...
Sarah Newbury (4461334) +3 more
core +1 more source
VirusesJingmenviruses have been identified over the past decade. During this period, significant advancements have been made in understanding their diversity, biology, and genomic functionality.
Egor V. Okhezin +3 more
doaj +1 more source
Natural Variation in XRN1 and its Role in Determining Antiviral Specificity
, 2017 XRN1 degrades uncapped cellular RNAs as part of RNA metabolism. Since viral RNAs are also uncapped, XRN1 can act as an antiviral defense mechanism. In this project, we examined the effectiveness and specificity of XRN1 to recognize and destroy double ...
Rowley, Paul A., (Mentor) +1 more
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Cytoplasmic Control of Sense-Antisense mRNA Pairs
Cell Reports, 2015 Transcriptome analyses have revealed that convergent gene transcription can produce many 3′-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3′-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and ...
Flore Sinturel +6 more
doaj +1 more source
Xrn1 controls Parp9/14 activation.
Activation of the enzymes Parp9 and Parp14 is a common transcriptional feature of pathways important for IBD, identified by gene or casual variant of interest, including NOD2, TRIM22, and XIAP. Aberrant Parp9/14 pathway signaling is found in NOD2 mutant cells and in patient tissues of humans with IBD (Crohn's Disease).
openaire +2 more sources