Results 111 to 120 of about 4,960 (183)

Transcriptomic screen for XRN1 associated functional networks in colorectal cancer

Ribonucleases are fundamental for many cellular and developmental processes and defects in their expression are associated with human disease. XRN1 is a highly conserved cytoplasmic exoribonuclease which degrades RNAs in a 5’-3’ direction and mutations ...
Costa, Paulo, Romão, Luísa
core  

Recruitment of Xrn1 to stress-induced genes allows efficient transcription by controlling RNA polymerase II backtracking

A new paradigm has emerged proposing that the crosstalk between nuclear transcription and cytoplasmic mRNA stability keeps robust mRNA levels in cells under steady-state conditions.
Paula Alepuz, María E Pérez-Martínez, José García-Martínez, José E Pérez-Ortín   +3 more
core   +1 more source

XRN1 wt Allele [PDF]

, 2020
openaire   +1 more source

An exploration of viral RNA-mediated strategies to stall and repress the cellular exoribonuclease XRN1 [PDF]

, 2018
2018 Fall.Includes bibliographical references.The regulation of mRNA decay plays a vital role in determining both the level and quality control of cellular gene expression in eukaryotes.
Zabel, Mark, committee member, Charley, Phillida A., author, Wilusz, Jeffrey, advisor, Perera, Rushika, committee member, Reddy, Anireddy, committee member   +4 more
core  

A structural bridge between dengue virus tandem xrRNAs facilitates coordination of exonuclease resistance. [PDF]

mBio
Spear E, O'Donoghue Z, Bonilla SL, Larsen KP, Sherlock ME, Kieft JS.   +5 more
europepmc   +1 more source

Nascent chain folding feeds back on mRNA stability through the ribosome: Consequences for therapeutic mRNA design. [PDF]

Mol Ther Nucleic Acids
Chang S, Coller J.
europepmc   +1 more source

Stalled translation on transcripts cleaved by RNase L activates signaling important for innate immunity. [PDF]

RNA
Karasik A, Jones GD, Guydosh NR.
europepmc   +1 more source

Uncovering a novel function of the exonuclease Xrn1 in viral and cellular mRNA translation

The exonuclease Xrn1 degrades messenger RNAs (mRNAs) and controls transcription. By using a model system that replicates brome mosaic virus (BMV) in yeast, here we show that Xrn1 promotes translation initiation of BMV RNA.
Blasco Moreno, Bernat
core  

Rational design of mechanically active RNAs: de novo engineering of functional exoribonuclease-resistant RNAs. [PDF]

Nucleic Acids Res
Walter J, Sidl L, Gutenbrunner K, Skibinski D, Kolberg T, Hofacker IL, Yao HT, Mörl M, Wolfinger MT.   +8 more
europepmc   +1 more source

N4BP1 uses tandem KH domains to associate with EDC4 and mRNA decapping factors in P-bodies. [PDF]

Commun Biol
Piłat P, Garg A, Heinemann U, Wilamowski M, Jura J.   +4 more
europepmc   +1 more source