Results 111 to 120 of about 7,632 (199)

Cytoplasmic Control of Sense-Antisense mRNA Pairs

Cell Reports, 2015
Transcriptome analyses have revealed that convergent gene transcription can produce many 3′-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3′-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and ...
Flore Sinturel, Albertas Navickas, Maxime Wery, Marc Descrimes, Antonin Morillon, Claire Torchet, Lionel Benard   +6 more
doaj   +1 more source

Signals Involved in Regulation of Hepatitis C Virus RNA Genome Translation and Replication [PDF]

, 2018
Hepatitis C Virus (HCV) preferentially replicates in the human liver and frequently causes chronic infection, often leading to cirrhosis and liver cancer.
Gerresheim, Gesche K., Niepmann, Michael, Rossbach, Oliver, Shalamova, Lyudmila A.   +3 more
core   +1 more source

The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay

eLife, 2019
Translation of problematic sequences in mRNAs leads to ribosome collisions that trigger a series of quality control events including ribosome rescue, degradation of the stalled nascent polypeptide, and targeting of the mRNA for decay (No Go Decay or NGD).
Karole N D'Orazio, Colin Chih-Chien Wu, Niladri Sinha, Raphael Loll-Krippleber, Grant W Brown, Rachel Green   +5 more
doaj   +1 more source

Yeast knockout library allows for efficient testing of genomic mutations for cell-free protein synthesis

Synthetic and Systems Biotechnology, 2016
Cell-free protein synthesis (CFPS) systems from crude lysates have benefitted from modifications to their enzyme composition. For example, functionally deleting enzymes in the source strain that are deleterious to CFPS can improve protein synthesis ...
Jennifer A. Schoborg, Lauren G. Clark, Alaksh Choudhury, C. Eric Hodgman, Michael C. Jewett   +4 more
doaj   +1 more source

Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response

eLife, 2019
In the unfolded protein response (UPR), stress in the endoplasmic reticulum (ER) activates a large transcriptional program to increase ER folding capacity.
Patrick D Cherry, Sally E Peach, Jay R Hesselberth   +2 more
doaj   +1 more source

Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity

eLife, 2017
Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a ‘histone replacement’ system in ...
Michael P Meers, Telmo Henriques, Christopher A Lavender, Daniel J McKay, Brian D Strahl, Robert J Duronio, Karen Adelman, A Gregory Matera   +7 more
doaj   +1 more source

Növényi RNS degradációs rendszerek: a nonsense-mediated decay rendszer molekuláris biológiája = RNA degradation systems in plants: the molecular biology of nonsense-mediated decay system [PDF]

, 2010
A program célja a növényi Nonsense-mediated mRNA decay (NMD) rendszer molekuláris biológiájának megismerése volt. Az NMD egy ősi eukarióta minőségbiztosítási rendszer, amely felismeri és lebontja a korai stop kodonokat (PTC) tartalmazó mRNS-eket, ezáltal
Hangyáné Benkovics, Anna, Kerényi, Zoltán, Mérai, Zsuzsanna, Nyikó, Tünde, Silhavy, Dániel   +4 more
core  

Characterisation of the in-vivo miRNA landscape in Drosophila ribonuclease mutants reveals Pacman-mediated regulation of the highly conserved let-7 cluster during apoptotic processes

Frontiers in Genetics
The control of gene expression is a fundamental process essential for correct development and to maintain homeostasis. Many post-transcriptional mechanisms exist to maintain the correct levels of each RNA transcript within the cell.
Elisa I. M. Bernard, Benjamin P. Towler, Benjamin P. Towler, Oliver M. Rogoyski, Sarah F. Newbury   +4 more
doaj   +1 more source

ePRINT: exonuclease assisted mapping of protein-RNA interactions

Genome Biology
RNA-binding proteins (RBPs) regulate key aspects of RNA processing including alternative splicing, mRNA degradation and localization by physically binding RNA molecules.
Sophie Hawkins, Alexandre Mondaini, Seema C. Namboori, Grady G. Nguyen, Gene W. Yeo, Asif Javed, Akshay Bhinge   +6 more
doaj   +1 more source

Fusarium mycotoxin-contaminated wheat containing deoxynivalenol alters the gene expression in the liver and the jejunum of broilers [PDF]

, 2017
The effects of mycotoxins in the production of animal feed were investigated using broiler chickens. For the feeding trial, naturally Fusarium mycotoxin-contaminated wheat was used, which mainly contained deoxynivalenol (DON). The main effects of DON are
Bucher, B., Dietrich, B., Neuenschwander, S., Wenk, C.   +3 more
core