Comparative analysis of flavivirus sfRNA dynamics and secondary structure. [PDF]
Journal of VirologyThe accumulation of subgenomic flavivirus RNAs (sfRNAs) modulates viral fitness and pathogenicity in culture and in vivo. These noncoding RNAs are produced by incomplete digestion of the flavivirus genome by the cellular 5′−3′ exoribonuclease (XRN1 ...
Graeme L Conn +2 more
exaly +5 more sources
Subgenomic flavivirus RNA (sfRNA) associated with Asian lineage Zika virus identified in three species of Ugandan bats (family Pteropodidae) [PDF]
Scientific Reports, 2021 Serological cross-reactivity among flaviviruses makes determining the prior arbovirus exposure of animals challenging in areas where multiple flavivirus strains are circulating.
Anna C Fagre +2 more
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Zika virus dumbbell-1 structure is critical for sfRNA presence and cytopathic effect during infection [PDF]
mBio, 2023 All flaviviruses contain conserved RNA structures in the 3′ untranslated region (3′ UTR) that are important for flavivirus RNA replication, translation, and pathogenesis.
Monica E. Graham +6 more
doaj +4 more sources
Noncoding RNA of Zika Virus Affects Interplay between Wnt-Signaling and Pro-Apoptotic Pathways in the Developing Brain Tissue [PDF]
Viruses, 2023 Zika virus (ZIKV) has a unique ability among flaviviruses to cross the placental barrier and infect the fetal brain causing severe abnormalities of neurodevelopment known collectively as congenital Zika syndrome. In our recent study, we demonstrated that
Alexander A. Khromykh +2 more
exaly +4 more sources
The anti-immune dengue subgenomic flaviviral RNA is present in vesicles in mosquito saliva and is associated with increased infectivity. [PDF]
PLoS Pathogens, 2023 Mosquito transmission of dengue viruses to humans starts with infection of skin resident cells at the biting site. There is great interest in identifying transmission-enhancing factors in mosquito saliva in order to counteract them.
Shih-Chia Yeh +20 more
doaj +3 more sources
UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation [PDF]
Advanced ScienceFlavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus ...
Oscar Trejo‐Cerro +7 more
doaj +3 more sources
Subgenomic Flaviviral RNAs of Dengue Viruses [PDF]
Viruses, 2023 Subgenomic flaviviral RNAs (sfRNAs) are produced during flavivirus infections in both arthropod and vertebrate cells. They are undegraded products originating from the viral 3′ untranslated region (3′ UTR), a result of the action of the host 5′-3 ...
Yi Liu, Wuxiang Guan, Haibin Liu
doaj +2 more sources
Chimeric Zika Viruses Containing xrRNA1 Elements of Divergent Flaviviruses Retain the Ability to Replicate in Vertebrate and Mosquito Cells and Produce Subgenomic Flaviviral RNA [PDF]
VirusesMembers of the Flaviviridae encode XRN1-resistant RNA structures (xrRNAs) within their 3′ untranslated regions (UTRs) that stall the cellular 5′→3′ exoribonuclease 1 (XRN1), resulting in the accumulation of subgenomic flavivirus RNAs (sfRNAs). Zika virus
Chandra S. Tangudu +4 more
doaj +2 more sources
Viruses, 2014 Flaviviruses are a large group of positive strand RNA viruses transmitted by arthropods that include many human pathogens such as West Nile virus (WNV), Japanese encephalitis virus (JEV), yellow fever virus, dengue virus, and tick-borne encephalitis ...
Alexander A. Khromykh +2 more
exaly +3 more sources
Nucleotide variations in 3’ untranslated region contribute to the enhanced virulence and replication efficiency of reemerging Japanese encephalitis virus genotype V [PDF]
VirulenceJapanese encephalitis virus, a major causative agent of viral encephalitis in Asia, is classified into five genotypes. Genotype V (GV) has reemerged after more than 50 years of apparent absence, following identification of the sole GV isolate – the Muar ...
Qiqi Xia +9 more
doaj +2 more sources