Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil [PDF]
PLoS Neglected Tropical Diseases, 2016 BackgroundThe outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern.
Alain Kohl +2 more
exaly +5 more sources
Zika Virus sfRNA Plays an Essential Role in the Infection of Insects and Mammals [PDF]
Proceedings, 2020 Similar to other flaviviruses, Zika virus (ZIKV) produces abundant subgenomic flavivirus RNA (sfRNA) derived from the 3’ untranslated region. The molecular mechanisms that determine the functions of sfRNA are currently not completely understood. Here, we
Andrii Slonchak +14 more
doaj +4 more sources
Structural analysis of 3’UTRs in insect flaviviruses reveals novel determinants of sfRNA biogenesis and provides new insights into flavivirus evolution [PDF]
Nature Communications, 2022 Subgenomic flaviviral RNAs (sfRNAs) are produced by pathogenic flaviviruses to counteract the host antiviral response. sfRNAs are products of incomplete degradation of viral RNA by the host exoribonuclease XRN1 which stalls on XRN1-resistant structural ...
Andrii Slonchak +12 more
doaj +7 more sources
A structural bridge between dengue virus tandem xrRNAs facilitates coordination of exonuclease resistance [PDF]
mBioOrthoflavivirus RNA genomes resist host 5′–3′ exoribonucleases to produce subgenomic flaviviral RNAs (sfRNAs). This resistance is conferred by exoribonuclease-resistant RNA (xrRNA) structures within the viral 3′ untranslated region that often occur in ...
Elizabeth Spear +5 more
doaj +2 more sources
West Nile Virus Subgenomic RNAs Modulate Gene Expression in a Neuronal Cell Line [PDF]
VirusesSubgenomic flaviviral RNAs (sfRNAs) are small non-coding products of the incomplete degradation of viral genomic RNA. They accumulate during flaviviral infection and have been associated with many functional roles inside the host cell.
Maria Bampali +5 more
doaj +2 more sources
Subgenomic flaviviral RNAs and human proteins: in silico exploration of anti-host defense mechanisms [PDF]
Computational and Structural Biotechnology JournalFlaviviruses pose significant global health threats, infecting over 300 million people annually. Among their evasion strategies, the production of subgenomic flaviviral RNAs (sfRNAs) from the 3′ UTR of viral genomes is particularly notable.
Riccardo Delli Ponti +2 more
doaj +2 more sources
Universal and quantitative detection of double-stranded RNAs as a signature of pan-virus infections using a luciferase-based biosensor [PDF]
Journal of Biological EngineeringBackground Infections with various RNA viruses and certain DNA viruses may produce double-stranded RNA (dsRNA) during replication, which trigger host innate immune responses.
Michihito Sasaki +8 more
doaj +2 more sources
Viruses, 2020 The Zika virus (ZIKV), like other flaviviruses, produces several species of sub-genomic RNAs (sfRNAs) during infection, corresponding to noncoding RNA fragments of different lengths that result from the exonuclease degradation of the viral 3 ...
J David Beckham +2 more
exaly +3 more sources
Pan-flavivirus analysis reveals sfRNA-independent, 3' UTR-biased siRNA production from an insect-specific flavivirus. [PDF]
J Virol, 2022 ABSTRACT RNA interference (RNAi) plays an essential role in mosquito antiviral immunity, but it is not known whether viral siRNA profiles differ between mosquito-borne and mosquito-specific viruses. A pan-Orthoflavivirus analysis in Aedes albopictus cells revealed that viral siRNAs ...
Besson B +4 more
europepmc +6 more sources
Determinant host differences in ZIKV sfRNA accumulation
ABSTRACT Zika virus ( Orthoflavivirus zikaese) is part of the Orthoflavivirus genus that contains several viral species posing major and expanding burdens to public health worldwide.
Ricciardi-Jorge T +3 more
europepmc +2 more sources