Results 31 to 40 of about 641 (96)

The conserved stem-loop II structure at the 3' untranslated region of Japanese encephalitis virus genome is required for the formation of subgenomic flaviviral RNA.

PLoS ONE, 2018
Flaviviruses accumulate abundant subgenomic RNA (sfRNA) in infected cells. It has been reported that sfRNA results from stalling of host 5'-to-3' exoribonuclease XRN1 at the highly structured RNA of the 3' untranslated region (UTR).
Yi-Shiuan Chen, Yi-Hsin Fan, Chih-Feng Tien, Andrew Yueh, Ruey-Yi Chang   +4 more
doaj   +1 more source

Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections

Journal of Immunology Research, Volume 2020, Issue 1, 2020., 2020
Type I interferons (IFN‐I) are a group of related proteins that help regulate the activity of the immune system and play a key role in host defense against viral infections. Upon infection, the IFN‐I are rapidly secreted and induce a wide range of effects that not only act upon innate immune cells but also modulate the adaptive immune system. While IFN‐
Patricio L. Acosta, Alana B. Byrne, Diego R. Hijano, Laura B. Talarico, Kurt Blaser   +4 more
wiley   +1 more source

Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

eLife, 2018
Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA.
Ruben Soto-Acosta, Xuping Xie, Chao Shan, Coleman K Baker, Pei-Yong Shi, Shannan L Rossi, Mariano A Garcia-Blanco, Shelton Bradrick   +7 more
doaj   +1 more source

Variability in Susceptibility to Type I Interferon Response and Subgenomic RNA Accumulation Between Clinical Isolates of Dengue and Zika Virus From Oaxaca Mexico Correlate With Replication Efficiency in Human Cells and Disease Severity

Frontiers in Cellular and Infection Microbiology, 2022
Dengue and Zika viruses cocirculate annually in endemic areas of Mexico, causing outbreaks of different magnitude and severity every year, suggesting a continuous selection of Flavivirus variants with variable phenotypes of transmissibility and virulence.
Tannya Karen Castro-Jiménez, Laura Cristina Gómez-Legorreta, Laura Alejandra López-Campa, Valeria Martínez-Torres, Marcos Alvarado-Silva, Araceli Posadas-Mondragón, Nallely Díaz-Lima, Hilda Arcelia Angulo-Mendez, Nancy R. Mejía-Domínguez, Felipe Vaca-Paniagua, Federico Ávila-Moreno, Julio García-Cordero, Leticia Cedillo-Barrón, Sergio Roberto Aguilar-Ruíz, José Bustos-Arriaga   +14 more
doaj   +1 more source

G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA. [PDF]

PLoS Pathogens, 2014
Viral RNA-host protein interactions are critical for replication of flaviviruses, a genus of positive-strand RNA viruses comprising major vector-borne human pathogens including dengue viruses (DENV). We examined three conserved host RNA-binding proteins (
Katell Bidet, Dhivya Dadlani, Mariano A Garcia-Blanco   +2 more
doaj   +1 more source

Evolution of Subgenomic RNA Shapes Dengue Virus Adaptation and Epidemiological Fitness

iScience, 2019
Summary: Changes in dengue virus (DENV) genome affect viral fitness both clinically and epidemiologically. Even in the 3′ untranslated region (3′ UTR), mutations could affect subgenomic flaviviral RNA (sfRNA) production and its affinity for host proteins,
Esteban Finol, Eng Eong Ooi
doaj   +1 more source

RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA

eLife, 2014
Dengue virus is a growing global health threat. Dengue and other flaviviruses commandeer the host cell’s RNA degradation machinery to generate the small flaviviral RNA (sfRNA), a noncoding RNA that induces cytopathicity and pathogenesis.
Erich G Chapman, Stephanie L Moon, Jeffrey Wilusz, Jeffrey S Kieft   +3 more
doaj   +1 more source

Regulation of Host Innate Immunity by Non-Coding RNAs During Dengue Virus Infection

Frontiers in Cellular and Infection Microbiology, 2020
An estimated 3.9 billion individuals in 128 nations (about 40% of global population) are at risk of acquiring dengue virus infection. About 390 million cases of dengue are reported each year with higher prevalence in the developing world.
Roopali Rajput, Roopali Rajput, Jitender Sharma, Mahima T. Nair, Madhu Khanna, Pooja Arora, Vikas Sood   +6 more
doaj   +1 more source

Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells. [PDF]

PLoS Pathogens, 2017
The Flavivirus genus includes a large number of medically relevant pathogens that cycle between humans and arthropods. This host alternation imposes a selective pressure on the viral population.
Claudia V Filomatori, Juan M Carballeda, Sergio M Villordo, Sebastian Aguirre, Horacio M Pallarés, Ana M Maestre, Irma Sánchez-Vargas, Carol D Blair, Cintia Fabri, Maria A Morales, Ana Fernandez-Sesma, Andrea V Gamarnik   +11 more
doaj   +1 more source

Histopathological Alterations and Dysregulation of Type I Interferon Signaling in the Human Cerebral Cortex During Severe Dengue

Journal of Medical Virology, Volume 97, Issue 10, October 2025.
ABSTRACT Dengue virus (DENV) is a major arthropod‐borne pathogen, endemic in over 100 countries and posing global health challenges. While innate immune responses and viral evasion mechanisms have been extensively studied in animal models and mononuclear cells, severe dengue can affect multiple tissues, including the central nervous system (CNS ...
Leandro Mantovani de Castro, Elaine Raniero Fernandes, Juarez Antonio Simoes Quaresma, Carmen Lucia Penteado Lancelotti, Maria Irma Seixas Duarte, Leda Viegas de Carvalho, Ricardo Penny, Pedro Fernando da Costa Vasconcelos, Evandro Sobroza de Mello, Mirian Nacagami Sotto, Carla Pagliari   +10 more
wiley   +1 more source