Results 71 to 80 of about 7,632 (199)

Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors [PDF]

, 2016
Small non-coding RNAs called piRNAs serve as guides for an adaptable immune system that represses transposable elements in germ cells of Metazoa. In Drosophila the RDC complex, composed of Rhino, Deadlock and Cutoff (Cuff) bind chromatin of dual-strand ...
Aravin, Alexei A., Chen, Yung-Chia Ariel, Fejes Toth, Katalin, Laver, John D., Le Thomas, Adrien, Li, Sisi, Lipshitz, Howard D., Luo, Yicheng, Ninova, Maria, Patel, Dinshaw J., Rozhavskaya, Ekaterina, Smibert, Craig A., Stuwe, Evelyn, Vempati, Sivani   +13 more
core   +2 more sources

Conserved Functions of LARP1 Proteins in Eukaryotes

WIREs RNA, Volume 16, Issue 6, November/December 2025.
LARP1 proteins are evolutionary conserved, and their function is influenced by both independent and coordinated roles of the La Motif and DM15 region, with a net effect on mRNA translation and stability. ABSTRACT La and La‐related proteins (LARPs) are conserved RNA‐binding proteins that share a characteristic La motif (LaM) and have important functions
Farnaz Mansouri‐Noori, Mark A. Bayfield   +1 more
wiley   +1 more source

Comparison of Xrn1 and Rat1 5′ → 3′ exoribonucleases in budding yeast supports the specific role of Xrn1 in cotranslational mRNA decay

Yeast
AbstractThe yeast Saccharomyces cerevisiae and most eukaryotes carry two 5′ → 3′ exoribonuclease paralogs. In yeast, they are called Xrn1, which shuttles between the nucleus and the cytoplasm, and executes major cytoplasmic messenger RNA (mRNA) decay, and Rat1, which carries a strong nuclear localization sequence (NLS) and localizes to the nucleus ...
José E. Pérez‐Ortín, Antonio Jordán‐Pla, Yujie Zhang, Jorge Moreno‐García, Claudio Bassot, Marina Barba‐Aliaga, Leire de Campos‐Mata, Mordechai Choder, Juana Díez, Ilaria Piazza, Vicent Pelechano, José García‐Martínez   +11 more
openaire   +5 more sources

Liquid–Liquid Phase Separation: Mechanisms, Roles, and Implications in Cellular Function and Disease

FASEB BioAdvances, Volume 7, Issue 11, November 2025.
Liquid–liquid phase separation (LLPS) is a fundamental biophysical process responsible for forming membraneless organelles involved in key cellular functions like chromatin organization and gene expression. Dysregulation of LLPS contributes to various diseases, including neurodegenerative disorders.
Dikesh Kumar Thakur, Sonal Padole, Tapati Sarkar, Somasundaram Arumugam, Shiladitya Chattopadhyay   +4 more
wiley   +1 more source

tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. [PDF]

, 2019
Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR).
Peschek, Jirka, Walter, Peter
core  

A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability [PDF]

, 2012
All arthropod-borne flaviviruses generate a short noncoding RNA (sfRNA) from the viral 3′ untranslated region during infection due to stalling of the cellular 5′-to-3′ exonuclease XRN1.
Akira, Shizuo, Anderson, John R., Khromykh, Alexander A., Kumagai, Yutaro, Moon, Stephanie L., Wilusz, Carol J., Wilusz, Jeffrey   +6 more
core   +1 more source

Mn-XRN1 Has an Inhibitory Effect on Ovarian Reproduction in Macrobrachium nipponense

Genes, 2023
XRN1 is an exoribonuclease that degrades mRNA in the cytoplasm along the 5′–3′ direction. A previous study indicated that it may be involved in the reproduction of Macrobrachium nipponense. Quantitative real-time PCR was used to detect the spatiotemporal expression pattern of Mn-XRN1.
Tianyong Chen, Huwei Yuan, Hui Qiao, Sufei Jiang, Wenyi Zhang, Yiwei Xiong, Hongtuo Fu, Shubo Jin   +7 more
openaire   +2 more sources

Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

eLife, 2018
Alterations in global mRNA decay broadly impact multiple stages of gene expression, although signals that connect these processes are incompletely defined.
Sarah Gilbertson, Joel D Federspiel, Ella Hartenian, Ileana M Cristea, Britt Glaunsinger   +4 more
doaj   +1 more source

Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication

Viruses, 2020
The Zika virus (ZIKV), like other flaviviruses, produces several species of sub-genomic RNAs (sfRNAs) during infection, corresponding to noncoding RNA fragments of different lengths that result from the exonuclease degradation of the viral 3 ...
Hadrian Sparks, Brendan Monogue, Benjamin Akiyama, Jeffrey Kieft, J. David Beckham   +4 more
doaj   +1 more source

FTO‐mediated m6A demethylation regulates IGFBP3 expression and AKT activation through IMP3‐dependent P‐body re‐localisation in lung cancer

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
FTO regulates the translation of IGFBP3 by demethylating m6A sites in the 3′‐untranslated region of IGFBP3 mRNA. Binding of the m6A reader protein IMP3 to 3′UTR m6A sites in IGFBP3 mRNA promoted its localisation and sequestration in cellular organelles known as to P‐bodies, thereby suppressing IGFBP3 mRNA translation. IGFBP3 regulates activation of the
Haiyang Wang, Hui Peng, Zhenzhen Zhang, Yilimunuer Abulimiti, Jiayi Hu, Yongxin Zhou, Ping Ji, Dong Li   +7 more
wiley   +1 more source