Results 161 to 170 of about 168,932 (404)

The role of exosomes and exosomal microRNA in diabetic cardiomyopathy

Frontiers in Endocrinology
Diabetic cardiomyopathy, a formidable cardiovascular complication linked to diabetes, is witnessing a relentless surge in its incidence. Despite extensive research efforts, the primary pathogenic mechanisms underlying this condition remain elusive. Consequently, a critical research imperative lies in identifying a sensitive and dependable marker for ...
Shiyu Gao, Yue Dong, Chentao Yan, Tianhao Yu, Hongbo Cao   +4 more
openaire   +3 more sources

Nuclear Surveillance and Degradation of Hypomodified Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e in \u3cem\u3eS. cerevisiae\u3c/em\u3e [PDF]

, 2004
The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a defective m1A methyltransferase (Mtase) and a temperature-sensitive growth phenotype
Anderson, James T., Hinnebusch, Alan G., Kadaba, Sujatha, Krecic, Annette M., Krueger, Anna, Trice, Tamyra   +5 more
core   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Pseudotyping exosomes for enhanced protein delivery in mammalian cells. [PDF]

, 2017
Exosomes are cell-derived nanovesicles that hold promise as living vehicles for intracellular delivery of therapeutics to mammalian cells. This potential, however, is undermined by the lack of effective methods to load exosomes with therapeutic proteins ...
Li, Lingxuan, Losacco, Joseph, Lu, Biao, Marriott, Gerard, Meyer, Conary, Stickney, Zachary   +5 more
core  

Exosomes are natural carriers of exogenous siRNA to human cells in vitro [PDF]

, 2013
© 2013 Shtam et al. Background: Exosomes are nano-sized vesicles of endocytic origin that are involved in cell-to-cell communication including shuttle RNA, mainly mRNA and microRNA.
Filatov, MV, Kil, YV, Kovalev, RA, Makarov, EM, Shtam, TA, Varfolomeeva, EY   +5 more
core   +1 more source

Exosome-Based Cell-Cell Communication in the Tumor Microenvironment

Front. Cell Dev. Biol., 2018
Tumors are not isolated entities, but complex systemic networks involving cell-cell communication between transformed and non-transformed cells. The milieu created by tumor-associated cells may either support or halt tumor progression.
Joana Maia, S. Caja, Maria Carolina Strano Moraes, Nuno Couto, B. Costa-Silva   +4 more
semanticscholar   +1 more source

Engineering a Human‐Sized Common Bile Duct Prototype with Regenerative Potential: In Vitro Evaluation of Mechanics, Function, Degradation, and Immune Modulation

Advanced Healthcare Materials, EarlyView.
This study presents a multiphasic bile duct construct composed of biocompatible materials and cells, featuring an inner layer that supports biliary epithelium growth, a middle layer providing mechanical strength, and an outer cell‐permissive layer designed to support future in vivo integration.
Mattia Pasqua, Marianna Barbuto, Matteo Calligaris, Roberto Di Gesù, Duilio Pagano, Rosalia Busà, Salvatore Gruttadauria, Simone Dario Scilabra, Antonio D'Amore, Maria Giovanna Francipane   +9 more
wiley   +1 more source

Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase

eLife, 2017
Nuclear RNA exosomes catalyze a range of RNA processing and decay activities that are coordinated in part by cofactors, including Mpp6, Rrp47, and the Mtr4 RNA helicase.
Elizabeth V Wasmuth, John C Zinder, Dimitrios Zattas, Mom Das, Christopher D Lima   +4 more
doaj   +1 more source

Degradation of ribosomal RNA precursors by the exosome [PDF]

, 2000
Christine Allmang
openalex   +1 more source

Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long‐Gap Peripheral Nerve Injury

Advanced Healthcare Materials, EarlyView.
A decellularized nerve graft (DNG) is modified to generate a porous DNG (PDNG). The PDNG is used to repair a 30‐mm peripheral nerve injury (PNI) defect, and is compared with isograft, serving as the standard, and DNG, a widely used alternative. The result shows that PDNG facilitated nerve regeneration in long‐gap PNI, evidenced by better‐aligned axonal
Olawale Alimi Alimi, Mitchell Kuss, Wen Xue, Bo Liu, Mena Asha Krishnan, Tianshu Pan, Zhi He, Han‐Jun Wang, Yuguo Lei, Kai Yang, Bin Duan   +10 more
wiley   +1 more source