Results 171 to 180 of about 143,013 (333)
Advanced Science, EarlyView.Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao +14 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan +16 more
wiley +1 more source
Early Effects of Porcine Placental Extracts and Stem Cell-Derived Exosomes on Aging Stress in Skin Cells [PDF]
Takaaki Matsuoka +3 more
openalex +1 more source
Advanced Science, EarlyView.Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei +10 more
wiley +1 more source
Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
Advanced Science, EarlyView.NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Advanced Science, EarlyView.A self‐healing hydrogel crosslinked with dynamic nucleobase‐mimetic bonds delivers curcumin‐loaded exosomes. It promotes diabetic wound healing via a synergistic combination of antibacterial, anti‐inflammatory, pro‐angiogenic, and immunomodulatory mechanisms, providing a comprehensive therapeutic approach.
Pu Yang +7 more
wiley +1 more source
Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy
Advanced Science, EarlyView.Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro +6 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2008 目的证实胶质瘤细胞是否可分泌exosome,并初步分析其蛋白组成,探讨胶质瘤来源exosome的潜在免疫调节功能,从而为进一步利用exosome对胶质瘤行免疫治疗提供理论依据。方法差速离心法从胶质瘤细胞培养上清液中提纯exosome,用透射电镜鉴定,利用SDS-PAGE初步分析exosome蛋白组成,并用western-blot验证hsp70的存在。结果胶质瘤细胞可以产生大小均一的囊泡性结构,即exosome,其平均直径约100 nm。exosome内所含蛋白质经初步分析,其表观分子量介于270-30 ...
杜嘉瑞 +6 more
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