Results 171 to 180 of about 83,398 (334)
Advanced Science, EarlyView.Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen +12 more
wiley +1 more source
Exosomes and their roles in the chemoresistance of pancreatic cancer
Cancer Medicine, Volume 11, Issue 24, Page 4979-4988, December 2022., 2022 Despite the development of multiple promising chemotherapeutic agents as recommended first‐line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance.Exploring the relation between exosomes and chemoresistance may be conducive to understanding molecular mechanisms and taking effective measures to reduce the ...
Yubin Pan +4 more
wiley +1 more source
Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway
Advanced Science, EarlyView.Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie +10 more
wiley +1 more source
TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex
, 2002 Nicolas Blanchard +6 more
openalex +1 more source
Proteomic Analysis of Exosomes Secreted by Human Mesothelioma Cells [PDF]
, 2004 Joost P. Hegmans +9 more
openalex +1 more source
Advanced Science, EarlyView.This work develops a cyanine dye named Cy‐BF and encapsulates it with phospholipids and platelet exosome vesicles to create CHL. Characterized by high phototoxicity, low dark toxicity, and enhanced tumor targeting, CHL demonstrates aggregation‐induced broadening of absorption spectra and NIR‐activated photothermal therapy and type I photodynamic ...
Yongjian Zhang +8 more
wiley +1 more source
The phospholipid flippase ATP8B1 is required for lysosomal fusion in macrophages
Cell Biochemistry and Function, Volume 40, Issue 8, Page 914-925, December 2022., 2022 Abstract ATP8B1 is a phospholipid flippase and member of the type 4 subfamily of P‐type ATPases (P4‐ATPase) subfamily. P4‐ATPases catalyze the translocation of phospholipids across biological membranes, ensuring proper membrane asymmetry, which is crucial for membrane protein targeting and activity, vesicle biogenesis, and barrier function.
Valentina E. Gómez‐Mellado +7 more
wiley +1 more source
The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements
, 2002 Dwaipayan Mukherjee
openalex +2 more sources
Exosome Secretion: The Art of Reutilizing Nonrecycled Proteins? [PDF]
, 2004 Aude De Gassart +3 more
openalex +1 more source
Advanced Science, EarlyView.Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen +9 more
wiley +1 more source