Results 291 to 300 of about 130,935 (361)

Nrd1 Interacts with the Nuclear Exosome for 3′ Processing of RNA Polymerase II Transcripts

, 2006
Lidia Vasiljeva, Stephen Buratowski
openalex   +1 more source

Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis

Advanced Science, EarlyView.
Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan, Xinbo Zhao, Xuejie Han, Yukai Cao, Xuexin Jin, Ling Shi, Xin Bi, Desheng Li, Yun Zhang, Wenbo Ma, Jiahui Song, Zhenwei Pan, Zhiren Zhang, Yue Li   +13 more
wiley   +1 more source

Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation. [PDF]

PLoS Biol
Feng X, Wang X, Guang S, Pang S, Tang H.
europepmc   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

Advanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei, Chi Wang, Xiangyan Chen, Yuanyuan Zhu, Mei Yang, Ningxi Li, Honglin Huang, Guangjian Zhang, Mingzhen Zhang, Yiyao Liu, Rui Gao   +10 more
wiley   +1 more source

Synergizing sono-piezo with exosome suppression using doping-engineered hydroxyapatite for potentiated tumor treatment through immunoactivation. [PDF]

J Nanobiotechnology
Qu X, Fan Q, Liu Y, Zhang J, Yuan B, Cai X, Ji L, Zhuang R, Dong Z.   +8 more
europepmc   +1 more source

SenExo‐cCCT2 Reprograms Senescence Response and Anti‐Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study demonstrates that SenExo‐cCCT2 enables targeted delivery of cCCT2 to pancreatic cancer cells, where it disrupts IPO13‐mediated nuclear translocation of UBC9, impairing SUMOylation‐dependent DNA damage repair and inducing senescence. Senescent tumor cells secrete CXCL10 to recruit CD8⁺ T‐cells while upregulating PD‐L1.
Shuncang Zhu, Yinhao Chen, Hongyi Lin, Jinpeng Lu, Yu Pan, Ge Li, Yongding Wu, Haoxiang Zhang, Xiaoxiao Huang, Yiting Chen, Huangjing Chen, Long Jin, Min Huang, Chengyu Liao, Long Huang, Yifeng Tian, Zuwei Wang, Qiaowei Li, Shi Chen   +18 more
wiley   +1 more source

Correction to Role of Exosome in Solid Cancer Progression and Its Potential Therapeutics in Cancer Treatment. [PDF]

Cancer Med
europepmc   +1 more source

The RNA binding protein hnRNP A/B controls exosomal miR-27a-5p loading during Salmonella infection. [PDF]

Poult Sci
Qu M, Zhang J, Yu X, Jiang L, Zhu H, Zhang X.   +5 more
europepmc   +1 more source

Tendon Aging: A Silent Enemy Revealed Strategies for Effective Treatment

AGING MEDICINE, EarlyView.
This review commences with the mechanism of tendon aging, mainly introducing the aging of tendons induced by oxidative stress, hyperglycemia, inflammatory response, cell apoptosis, and fatty infiltration and the association with the tendon stem/progenitor cells, aiming to explore the mechanism of aging and find related treatment methods.
Wenhui Gu, Guohua Wang, Haifeng Zhang, Yinxian Yu   +3 more
wiley   +1 more source

Mesenchymal stem cell-derived exosomes and the Wnt/β-catenin pathway: Unifying mechanisms of multi-organ regeneration and the path to precision clinical translation. [PDF]

World J Stem Cells
Yan X, Guo YX, Liu YX, Liu C.
europepmc   +1 more source