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Exosome and exosomal contents in schizophrenia
Journal of Psychiatric Research, 2023Schizophrenia (SCZ) is a severe mental disorder that affects approximately 1% general population worldwide and poses a considerable burden to society. Despite decades of research, its etiology remains unclear, and diagnosis remains challenging due to its heterogeneous symptoms.
Tingkai, Zhang +4 more
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Annual Review of Biochemistry, 2019
Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are ...
Pegtel, D. Michiel, Gould, Stephen J.
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Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are ...
Pegtel, D. Michiel, Gould, Stephen J.
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Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications
Journal of Controlled Release, 2023Exosomes are endosome-derived nanovesicles involved in cellular communication. They are natural nanocarriers secreted by various cells, making them suitable candidates for diverse drug delivery and therapeutic applications from a material standpoint. They have a phospholipid bilayer decorated with functional molecules and an enclosed parental matrix ...
Jagannath, Mondal +6 more
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2008
Exosomes are small natural membrane vesicles released by a wide variety of cell types into the extracellular compartment by exocytosis. The biological functions of exosomes are only slowly unveiled, but it is clear that they serve to remove unnecessary cellular proteins (e.g., during reticulocyte maturation) and act as intercellular messengers because ...
Joost P J J, Hegmans +2 more
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Exosomes are small natural membrane vesicles released by a wide variety of cell types into the extracellular compartment by exocytosis. The biological functions of exosomes are only slowly unveiled, but it is clear that they serve to remove unnecessary cellular proteins (e.g., during reticulocyte maturation) and act as intercellular messengers because ...
Joost P J J, Hegmans +2 more
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Exosomes and Exosomal microRNAs in Age-associated Stroke
Current Vascular Pharmacology, 2021Aging has been considered to be the most important non-modifiable risk factor for stroke and death. Changes in circulation factors in the systemic environment, cellular senescence and artery hypertension during human ageing have been investigated. Exosomes are nanosize membrane vesicles that can regulate target cell functions via delivering their ...
Xiudeng Zhu +6 more
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2021
Exosomes are small extracellular vesicles released by cells under physiological and pathological conditions. There is emerging evidence associating exosomes with tumorigenesis. They carry cargo (DNA, RNA, miRNA and protein) pertaining to the cell of origin and play a key role in intercellular communication, influencing several cellular processes ...
José Miguel Amenábar +4 more
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Exosomes are small extracellular vesicles released by cells under physiological and pathological conditions. There is emerging evidence associating exosomes with tumorigenesis. They carry cargo (DNA, RNA, miRNA and protein) pertaining to the cell of origin and play a key role in intercellular communication, influencing several cellular processes ...
José Miguel Amenábar +4 more
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Diabetes/Metabolism Research and Reviews, 2019
SummaryDiabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life‐threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resistance in peripheral tissues ...
Carlos Castaño +2 more
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SummaryDiabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life‐threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resistance in peripheral tissues ...
Carlos Castaño +2 more
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Transfusion Clinique et Biologique, 2010
Multivesicular endosomes contain membrane vesicles which can be released into the extracellular environment as exosomes. This review describes the role of exosome secretion in the remodeling of the red cell plasma membrane during the last stage of erythropoietic differentiation. Herein, we propose that the exosome biogenesis involves several mechanisms
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Multivesicular endosomes contain membrane vesicles which can be released into the extracellular environment as exosomes. This review describes the role of exosome secretion in the remodeling of the red cell plasma membrane during the last stage of erythropoietic differentiation. Herein, we propose that the exosome biogenesis involves several mechanisms
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Science, 2014
Nanovesicles derived from cells of cancer patients carry microRNAs that initiate tumor growth in normal ...
Anastasiadou, Eleni, Slack, Frank J.
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Nanovesicles derived from cells of cancer patients carry microRNAs that initiate tumor growth in normal ...
Anastasiadou, Eleni, Slack, Frank J.
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2010
The archaeal exosome is aprotein complex with structural similarities to the eukaryotic exosome and bacterial PNPase. Its catalytic core is formed by alternating Rrp41 and Rrp42 polypeptides, arranged in a hexameric ring. A flexible RNA binding cap composed of the evolutionarily conserved proteins Rrp4 and/or Cs14 is bound at the top of the ring and ...
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The archaeal exosome is aprotein complex with structural similarities to the eukaryotic exosome and bacterial PNPase. Its catalytic core is formed by alternating Rrp41 and Rrp42 polypeptides, arranged in a hexameric ring. A flexible RNA binding cap composed of the evolutionarily conserved proteins Rrp4 and/or Cs14 is bound at the top of the ring and ...
openaire +4 more sources