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Exosomes

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2008
Exosomes are small natural membrane vesicles released by a wide variety of cell types into the extracellular compartment by exocytosis. The biological functions of exosomes are only slowly unveiled, but it is clear that they serve to remove unnecessary cellular proteins (e.g., during reticulocyte maturation) and act as intercellular messengers because ...
Joost P J J, Hegmans   +2 more
  +8 more sources

Exosome and exosomal contents in schizophrenia

Journal of Psychiatric Research, 2023
Schizophrenia (SCZ) is a severe mental disorder that affects approximately 1% general population worldwide and poses a considerable burden to society. Despite decades of research, its etiology remains unclear, and diagnosis remains challenging due to its heterogeneous symptoms.
Tingkai, Zhang   +4 more
openaire   +2 more sources

Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

Journal of Controlled Release, 2023
Exosomes are endosome-derived nanovesicles involved in cellular communication. They are natural nanocarriers secreted by various cells, making them suitable candidates for diverse drug delivery and therapeutic applications from a material standpoint. They have a phospholipid bilayer decorated with functional molecules and an enclosed parental matrix ...
Jagannath, Mondal   +6 more
openaire   +2 more sources

siRNA Loaded-Exosomes

2021
Exosomes are membrane-bound vesicles (40-100 nm) of endocytic origin released by numerous cell types that act as natural carriers of mRNA, microRNA, and proteins between cells. We developed a new system that uses intravenous injection of modified exosomes for siRNA delivery into the brain.
María, Izco, Lydia, Alvarez-Erviti
openaire   +2 more sources

Exosomes and diabetes

Diabetes/Metabolism Research and Reviews, 2019
SummaryDiabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life‐threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resistance in peripheral tissues ...
Carlos Castaño   +2 more
openaire   +2 more sources

Bone-derived exosomes

Current Opinion in Pharmacology, 2017
Exosomes are endosomal-derived vesicles secreted by a wide range of cell types for transporting functional proteins, microRNAs (miRNAs) and messenger RNAs (mRNA) from their parental cells to affect the recipient cells. Emerging evidence indicates that exosomes also play an important role in the intercellular communication among the bone cells, that is,
Jin, Liu   +5 more
openaire   +2 more sources

Exosome-based immunotherapy

Cancer Immunology, Immunotherapy, 2004
Exosomes are small membrane vesicles originating from late endosomes and secreted by hematopoietic and epithelial cells in culture. Exosome proteic and lipid composition is unique and might shed some light into exosome biogenesis and function. Exosomes secreted from professional antigen-presenting cells (i.e., B lymphocytes and dendritic cells) are ...
Nathalie, Chaput   +5 more
openaire   +2 more sources

Exosomes in erythropoiesis

Transfusion Clinique et Biologique, 2010
Multivesicular endosomes contain membrane vesicles which can be released into the extracellular environment as exosomes. This review describes the role of exosome secretion in the remodeling of the red cell plasma membrane during the last stage of erythropoietic differentiation. Herein, we propose that the exosome biogenesis involves several mechanisms
openaire   +3 more sources

Exosomes

2022
Timothy Ganey   +2 more
openaire   +2 more sources

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