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Exosome Processing and Characterization Approaches for Research and Technology Development
Advanced Science, 2022 Exosomes are extracellular vesicles that share components of their parent cells and are attractive in biotechnology and biomedical research as potential disease biomarkers as well as therapeutic agents.
James J Lai +2 more
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Tumour exosome integrins determine organotropic metastasis
Nature, 2015 Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident ...
Bruno Costa-silva +2 more
exaly +2 more sources
Traffic, 2021 Exosomes are extracellular vesicles that in recent years have received special attention for their regulatory functions in numerous biological processes.
Javier Donoso-quezada +2 more
exaly +2 more sources
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Exosome and exosomal contents in schizophrenia
Journal of Psychiatric Research, 2023Schizophrenia (SCZ) is a severe mental disorder that affects approximately 1% general population worldwide and poses a considerable burden to society. Despite decades of research, its etiology remains unclear, and diagnosis remains challenging due to its heterogeneous symptoms.
Tingkai, Zhang +4 more
openaire +2 more sources
Annual Review of Biochemistry, 2019
Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are ...
Pegtel, D. Michiel, Gould, Stephen J.
openaire +3 more sources
Exosomes are small, single-membrane, secreted organelles of ∼30 to ∼200 nm in diameter that have the same topology as the cell and are enriched in selected proteins, lipids, nucleic acids, and glycoconjugates. Exosomes contain an array of membrane-associated, high-order oligomeric protein complexes, display pronounced molecular heterogeneity, and are ...
Pegtel, D. Michiel, Gould, Stephen J.
openaire +3 more sources
Small, 2020
Exosomes are secreted by most cell types and circulate in body fluids. Recent studies have revealed that exosomes play a significant role in intercellular communication and are closely associated with the pathogenesis of disease.
Shujing Lin, Di Chen, Zhigang Wang
exaly +2 more sources
Exosomes are secreted by most cell types and circulate in body fluids. Recent studies have revealed that exosomes play a significant role in intercellular communication and are closely associated with the pathogenesis of disease.
Shujing Lin, Di Chen, Zhigang Wang
exaly +2 more sources
Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications
Journal of Controlled Release, 2023Exosomes are endosome-derived nanovesicles involved in cellular communication. They are natural nanocarriers secreted by various cells, making them suitable candidates for diverse drug delivery and therapeutic applications from a material standpoint. They have a phospholipid bilayer decorated with functional molecules and an enclosed parental matrix ...
Jagannath, Mondal +6 more
openaire +2 more sources
Analytical Chemistry, 2021
The exosome has emerged as a promising noninvasive biomarker for the early diagnosis of cancer. Therefore, it is highly desirable to develop simple, inexpensive, and user-friendly biosensors for convenient, sensitive, and quantitative exosome assay ...
Xiaojuan Liu +4 more
semanticscholar +1 more source
The exosome has emerged as a promising noninvasive biomarker for the early diagnosis of cancer. Therefore, it is highly desirable to develop simple, inexpensive, and user-friendly biosensors for convenient, sensitive, and quantitative exosome assay ...
Xiaojuan Liu +4 more
semanticscholar +1 more source
2008
Exosomes are small natural membrane vesicles released by a wide variety of cell types into the extracellular compartment by exocytosis. The biological functions of exosomes are only slowly unveiled, but it is clear that they serve to remove unnecessary cellular proteins (e.g., during reticulocyte maturation) and act as intercellular messengers because ...
Joost P J J, Hegmans +2 more
openaire +2 more sources
Exosomes are small natural membrane vesicles released by a wide variety of cell types into the extracellular compartment by exocytosis. The biological functions of exosomes are only slowly unveiled, but it is clear that they serve to remove unnecessary cellular proteins (e.g., during reticulocyte maturation) and act as intercellular messengers because ...
Joost P J J, Hegmans +2 more
openaire +2 more sources
Exosomes and Exosomal microRNAs in Age-associated Stroke
Current Vascular Pharmacology, 2021Aging has been considered to be the most important non-modifiable risk factor for stroke and death. Changes in circulation factors in the systemic environment, cellular senescence and artery hypertension during human ageing have been investigated. Exosomes are nanosize membrane vesicles that can regulate target cell functions via delivering their ...
Xiudeng Zhu +6 more
openaire +3 more sources