Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022 Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem +6 more
wiley +1 more source
Interplay of the RNA Exosome Complex and RNA-Binding Protein Ssd1 in Maintaining Cell Wall Stability in Yeast. [PDF]
Microbiol Spectr, 2021 Novačić A +4 more
europepmc +1 more source
Label-free detection of exosomes from different cellular sources based on surface-enhanced Raman spectroscopy combined with machine learning models [PDF]
arXivExosomes are significant facilitators of inter-cellular communication that can unveil cell-cell interactions, signaling pathways, regulatory mechanisms and disease diagnostics. Nonetheless, current analysis required large amount of data for exosome identification that it hampers efficient and timely mechanism study and diagnostics.
arxiv
Higher analogs of simplicial and combinatorial complexity [PDF]
arXiv, 2019 We introduce higher simplicial complexity of a simplicial complex $K$ and higher combinatorial complexity of a finite space $P$ (i.e. $P$ is a finite poset). We relate higher simplicial complexity with higher topological complexity of $|K|$ and higher combinatorial complexity with higher simplicial complexity of the order complex of $P$.
arxiv
Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts [PDF]
, 2022 Emi Soma +5 more
openalex +1 more source
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex. [PDF]
Cell Chem Biol, 2021 Angelbello AJ +11 more
europepmc +1 more source
On a special class of complex tori [PDF]
arXiv, 2004 We investigate which complex tori admits complex Lie subgroups whose closure is not complex.
arxiv
Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury
Advanced Science, EarlyView.Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang +5 more
wiley +1 more source
BiomoleculesThe exosome multiprotein complex plays a critical role in RNA processing and degradation. This system governs the regulation of mRNA quality, degradation in the cytoplasm, the processing of short noncoding RNA, and the breakdown of RNA fragments.
Seonha Park +7 more
doaj +1 more source